Interaction of the Cognitive and Sensory-cognitive Tasks With Postural Stability in Individuals With Stability Disorders

NCT05024240 | Unknown

• 1 other identifier: ID 14827
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to describe the interaction of the cognitive and visual-cognitive task with postural stability in patients suffering by cerebellar ataxia. Investigators will measure changes in postural stability parameters and in secondary task performance, which should show the ability of the patients to manage the dualtask situations.

Conditions

Cerebellar Ataxia; Cerebellar Diseases

Keywords

Stability; Dual Task; Cerebellum; Stroop Test; Backward Counting Test

Outcome Measures

Primary Outcomes (3)

• Centre of pressure - AREA (mm2)

  the area below the graph of the curve formed by the movement of the patient's center of gravity during the 30 seconds while standing on the platform, computer processed (Kistler programme), measured in squared millimeters

  1 week

• Centre of pressure - LENGHT (mm)

  the length of the curve formed by the movement of the patient's center of gravity during 30 seconds while standing on the platform, computer processed (Kistler programme), measured in millimeters

  1 week

• Reaction time in secondary tasks (ms)

  time (measured in milliseconds) between individual responses of probands in a cognitive or visual test, measured from an audio recording of proband´s responses using a professional audio editing program

  1 week

Study Arms (2)

Patient group

EXPERIMENTAL

20 patients with cerebellum disorders, who suffer from stability disorders and with specific 3 Hz tremor

Diagnostic Test: Stabilometry; Diagnostic Test: Stroop test; Diagnostic Test: Backward counting test

Control group

ACTIVE COMPARATOR

20 healthy age-matching probands without any neurological disorders and stability issues

Diagnostic Test: Stabilometry; Diagnostic Test: Stroop test; Diagnostic Test: Backward counting test

Interventions

Stabilometry DIAGNOSTIC_TEST

Probands will stand on stabilometric platform (double leg stance) and we will measure CoP parameters area and length. We also make this task harder by using foam and exclusion of visual control. Length of one test is 30s.

Control group; Patient group

Stroop test DIAGNOSTIC_TEST

There are various names of colours written in non-matching font colour in this test. During this test probands are required to name the colour which is written in text not the colour of the font. We will measure reaction time and number of mistakes.

Control group; Patient group

Backward counting test DIAGNOSTIC_TEST

In this counting test probands are given number from interval \<180-200\> and they are asked to subtract 7 during 30s interval of the testing. We will measure reaction time and number of mistakes.

Also known as: BCT

Control group; Patient group

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Hz tremor in in frequency analysis (posturografy)
• stability disorder caused by cerebellar disorders in diagnose

You may not qualify if:

• lower than high school education
• vestibular disorders
• ankle instability
• other specific stability disorders
• unability to stand for 30s

Sponsors & Collaborators

• Charles University, Czech Republic: lead

Study Sites (1)

Second Faculty of Medicine, Charles University

Prague, 15006, Czechia

Location

MeSH Terms

Conditions

Cerebellar Ataxia; Cerebellar Diseases

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Ataxia; Dyskinesias; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Pavel Kolář, Prof. PaedDr. Ph.D.

  Department of Rehabilitation and Sports Medicine, Second Faculty of Medicine, Charles University

  STUDY CHAIR

• Ondřej Čakrt, Doc. PhDr. Ph.D.

  Department of Rehabilitation and Sports Medicine, Second Faculty of Medicine, Charles University

  STUDY DIRECTOR

• Kateřina Levínská, Mgr.

  Department of Rehabilitation and Sports Medicine, Second Faculty of Medicine, Charles University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: SCREENING
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principal investigator

Model Details: There will be group of patients with disorders od cerebellum and control group of healthy age-matching probands

Study Record Dates

• First Submitted: August 11, 2021
• First Posted: August 27, 2021
• Study Start: October 10, 2018
• Primary Completion: September 1, 2021
• Study Completion: December 1, 2021
• Last Updated: August 27, 2021

Record last verified: 2021-08

Locations

CZ (1)