fMRI Study of Functional Reorganization in Glioma Patients

NCT05019196 | Unknown

• 1 other identifier: 2018SF-113
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

Glioma is an invasive growth, easy to relapse, poor prognosis, great harm to human and society. Studies have shown that gliomas can cause the dynamic reorganization of brain functional areas, affecting the accuracy of surgical resection and the evaluation of long-term efficacy. While, it is difficult to monitor the functional reorganization of glioma in existing studies. The development trend can not effectively predict the outcome of tumor anaplasia and the compensation of brain function, which restricts the accurate tumor resection. In the early stage of this study, functional connectivity analysis was carried out of gliomas in the motor region and showed that the damage of motor functional connectivity on the opposite side of the lesion occurred earlier than that on the same side, suggesting that there may be some rules of how the disease caused functional reorganization. After stroke, the language and motor function will undergo plasticity, causing the functional areas to slowly repair the damaged function. Contrast to stroke, low-grade glioma grows slower, which gives brain more time to adapt to the damage caused by tumor growth, it may cause more functional reorganization. Professor Hugues Duffau's research showed that it is brain plasticity that can effectively explain patients with low-grade gliomas, even in language and motor areas, did not appear obvious dysfunction. Our previous research found there were significant differences in motor functional connectivity between the two hemispheres of the patients between the plasma tumor group and healthy controls. In addition, in the tumor group, the damage of motor connection on the contralateral side of the lesion occurred before on the ipsilateral side. These results suggest that brain function has been remodeled in patients with brain tumors who have not yet exhibited motor impairment. We presume there may be a certain pattern of brain function reorganization caused by low-grade glioma. This study take patients with brain glioma as the research object and adopt a multi-time point experimental design, combining with cortical electrical stimulation and multimodal magnetic resonance imaging data before and after operation, intending to observe the dynamic changes of language and motor function networks.

Conditions

Glioma

Keywords

low-grade glioma; fMRI; function reorganization

Outcome Measures

Primary Outcomes (1)

• Analysis of functional connections between cerebral hemispheric regions

  This study selected the functional activation regions of the patients' own motor or language tasks were used as seed points for the functional connections of complex brain networks analysis. Each region of interest is defined as a sphere with a radius of 6mm for functional connection analysis. Among them, Pearson's correlation coefficient was used as a pairing calculation between brain regions in each patient. Apply the Fisher's r turnZ method is used to improve the normality of the correlation coefficient

  2021.12.1

Study Arms (1)

fMRI，functional reorganization, functional connectivity, functional rating scale

low-grade glioma patients healthy controls

Device: GE 3.0T MRI

Interventions

GE 3.0T MRI DEVICE

using GE 3.0T MRI to obtain anatomical and functional MR images and DTI images

fMRI，functional reorganization, functional connectivity, functional rating scale

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Fifty patients with right-handed low-grade glioma who met the inclusion and exclusion criteria were included

You may qualify if:

• All cases underwent no treatment or surgery before examination;
• Can cooperate to complete routine MRI, fMRI, DTI, and rfMRI were required and the image quality was graded the value of analysis;
• All cases were confirmed by craniotomy and pathology;
• Right-handed;
• Mass lesion located in the left dominant hemisphere
• single lesion;
• No chronic diseases such as hypertension and diabetes

You may not qualify if:

• History of neurological diseases;
• Previous history of brain trauma accompanied by consciousness disorder;
• Before scanning 6, a history of long-term use of psychoactive substances such as alcohol and drug within one month;
• Obviously mentally handicapped;
• magnetic resonance (NMR) check for contraindications;
• Family history of neuropsychiatric disorders

Sponsors & Collaborators

• First Affiliated Hospital Xi'an Jiaotong University: lead

Related Publications (18)

• Marusyk A, Almendro V, Polyak K. Intra-tumour heterogeneity: a looking glass for cancer? Nat Rev Cancer. 2012 Apr 19;12(5):323-34. doi: 10.1038/nrc3261.

  PMID: 22513401 RESULT

• Stupp R, Brada M, van den Bent MJ, Tonn JC, Pentheroudakis G; ESMO Guidelines Working Group. High-grade glioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2014 Sep;25 Suppl 3:iii93-101. doi: 10.1093/annonc/mdu050. Epub 2014 Apr 29. No abstract available.

  PMID: 24782454 RESULT

• Rosler J, Niraula B, Strack V, Zdunczyk A, Schilt S, Savolainen P, Lioumis P, Makela J, Vajkoczy P, Frey D, Picht T. Language mapping in healthy volunteers and brain tumor patients with a novel navigated TMS system: evidence of tumor-induced plasticity. Clin Neurophysiol. 2014 Mar;125(3):526-36. doi: 10.1016/j.clinph.2013.08.015. Epub 2013 Sep 16.

  PMID: 24051073 RESULT

• Southwell DG, Hervey-Jumper SL, Perry DW, Berger MS. Intraoperative mapping during repeat awake craniotomy reveals the functional plasticity of adult cortex. J Neurosurg. 2016 May;124(5):1460-9. doi: 10.3171/2015.5.JNS142833. Epub 2015 Nov 6.

  PMID: 26544767 RESULT

• Duffau H. The huge plastic potential of adult brain and the role of connectomics: new insights provided by serial mappings in glioma surgery. Cortex. 2014 Sep;58:325-37. doi: 10.1016/j.cortex.2013.08.005. Epub 2013 Aug 19.

  PMID: 24050218 RESULT

• Saito T, Muragaki Y, Miura I, Tamura M, Maruyama T, Nitta M, Kurisu K, Iseki H, Okada Y. Functional plasticity of language confirmed with intraoperative electrical stimulations and updated neuronavigation: case report of low-grade glioma of the left inferior frontal gyrus. Neurol Med Chir (Tokyo). 2014;54(7):587-92. doi: 10.2176/nmc.cr.2013-0248. Epub 2014 Feb 28.

  PMID: 24584281 RESULT

• Duffau H. Lessons from brain mapping in surgery for low-grade glioma: insights into associations between tumour and brain plasticity. Lancet Neurol. 2005 Aug;4(8):476-86. doi: 10.1016/S1474-4422(05)70140-X.

  PMID: 16033690 RESULT

• Duffau H. Diffuse low-grade gliomas and neuroplasticity. Diagn Interv Imaging. 2014 Oct;95(10):945-55. doi: 10.1016/j.diii.2014.08.001. Epub 2014 Sep 16.

  PMID: 25218490 RESULT

• Briganti C, Sestieri C, Mattei PA, Esposito R, Galzio RJ, Tartaro A, Romani GL, Caulo M. Reorganization of functional connectivity of the language network in patients with brain gliomas. AJNR Am J Neuroradiol. 2012 Nov;33(10):1983-90. doi: 10.3174/ajnr.A3064. Epub 2012 May 3.

  PMID: 22555573 RESULT

• Otten ML, Mikell CB, Youngerman BE, Liston C, Sisti MB, Bruce JN, Small SA, McKhann GM 2nd. Motor deficits correlate with resting state motor network connectivity in patients with brain tumours. Brain. 2012 Apr;135(Pt 4):1017-26. doi: 10.1093/brain/aws041. Epub 2012 Mar 8.

  PMID: 22408270 RESULT

• Desmurget M, Bonnetblanc F, Duffau H. Contrasting acute and slow-growing lesions: a new door to brain plasticity. Brain. 2007 Apr;130(Pt 4):898-914. doi: 10.1093/brain/awl300. Epub 2006 Nov 21.

  PMID: 17121742 RESULT

• Abd-El-Barr MM, Saleh E, Huang RY, Golby AJ. Effect of disease and recovery on functional anatomy in brain tumor patients: insights from functional MRI and diffusion tensor imaging. Imaging Med. 2013 Aug 1;5(4):333-346. doi: 10.2217/iim.13.40.

  PMID: 24660024 RESULT

• Tuntiyatorn L, Wuttiplakorn L, Laohawiriyakamol K. Plasticity of the motor cortex in patients with brain tumors and arteriovenous malformations: a functional MR study. J Med Assoc Thai. 2011 Sep;94(9):1134-40.

  PMID: 21970205 RESULT

• Kosla K, Pfajfer L, Bryszewski B, Jaskolski D, Stefanczyk L, Majos A. Functional rearrangement of language areas in patients with tumors of the central nervous system using functional magnetic resonance imaging. Pol J Radiol. 2012 Jul;77(3):39-45. doi: 10.12659/pjr.883373.

  PMID: 23049580 RESULT

• Bryszewski B, Pfajfer L, Antosik-Biernacka A, Tybor K, Smigielski J, Zawirski M, Majos A. Functional rearrangement of the primary and secondary motor cortex in patients with primary tumors of the central nervous system located in the region of the central sulcus depending on the histopathological type and the size of tumor: Examination by means of functional magnetic resonance imaging. Pol J Radiol. 2012 Jan;77(1):12-20. doi: 10.12659/pjr.882576.

  PMID: 22802861 RESULT

• Niu C, Zhang M, Min Z, Rana N, Zhang Q, Liu X, Li M, Lin P. Motor network plasticity and low-frequency oscillations abnormalities in patients with brain gliomas: a functional MRI study. PLoS One. 2014 May 7;9(5):e96850. doi: 10.1371/journal.pone.0096850. eCollection 2014.

  PMID: 24806463 RESULT

• Small SL, Buccino G, Solodkin A. Brain repair after stroke--a novel neurological model. Nat Rev Neurol. 2013 Dec;9(12):698-707. doi: 10.1038/nrneurol.2013.222. Epub 2013 Nov 12.

  PMID: 24217509 RESULT

• Duffau H. Stimulation mapping of white matter tracts to study brain functional connectivity. Nat Rev Neurol. 2015 May;11(5):255-65. doi: 10.1038/nrneurol.2015.51. Epub 2015 Apr 7.

  PMID: 25848923 RESULT

MeSH Terms

Conditions

Glioma

Condition Hierarchy (Ancestors)

Neoplasms, Neuroepithelial; Neuroectodermal Tumors; Neoplasms, Germ Cell and Embryonal; Neoplasms by Histologic Type; Neoplasms; Neoplasms, Glandular and Epithelial; Neoplasms, Nerve Tissue

Study Officials

• Chen Niu, PhD

  First Affiliated Hospital Xi'an Jiaotong University

  STUDY DIRECTOR

Central Study Contacts

Chen Niu, PhD

CONTACT

0086-13619266896; niuchen.xjtu@mail.xjtu.edu.cn

Ming Zhang, PhD

CONTACT

0086-18991232265; zhangming01@mail.xjtu.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 19, 2021
• First Posted: August 24, 2021
• Study Start: September 1, 2021
• Primary Completion: December 31, 2022
• Study Completion: December 31, 2022
• Last Updated: August 24, 2021

Record last verified: 2020-08