Practice Variation on Antithrombotics in COVID-19

NCT04998799 | Completed

• 1 other identifier: ATCOVIDIndia
• Study Type: observational
• Target: 435
• Locations: 1 country
• Sites: 1

Brief Summary

Evidence suggests coronavirus disease 2019 (COVID-19) is associated with an increased incidence of thromboembolic manifestations. Various guidelines on managing antithrombotics in COVID-19 either provided conflicting guidance or unclear recommendations for post-discharge thromboprophylaxis. The investigators aim to collect the current practices in India among physicians on antithrombotic therapy for hospitalised patients with COVID-19 and after discharge from the hospital.

Conditions

COVID-19 Pneumonia; Thrombosis; COVID-19 Acute Respiratory Distress Syndrome; Severe Acute Respiratory Syndrome (SARS) Pneumonia

Keywords

Anticoagulation in COVID-19; Anticoagulants; SARS-CoV-2; Coronavirus Disease 2019; Management of COVID-19

Outcome Measures

Primary Outcomes (1)

• Choice, dose, and indication of antithrombotics for management of COVID-19.

  Through web-based cross-sectional survey will capture the practices of physicians on choice, dose, and indication of antithrombotics for management of COVID-19 during hospitalisation and post-discharge

  two weeks

Interventions

Current clinical practices of participating physicians BEHAVIORAL

Current clinical practice of participating physicians on management of antithrombotics for COVID-19 during hospitalisation and post-discharge

Eligibility Criteria

• Age: 20 Years - 70 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Physicians from different specialities like Internal Medicine, Pulmonary Medicine, Anesthesiologists, Critical Care Medicine will be recruited through snowballing sampling. A web-based cross-sectional survey will be circulated among the target population by the investigators through e-mail and social media channels.

You may qualify if:

• Physicians involved in the management of adult hospitalised patients with COVID-19 in India

You may not qualify if:

• Pediatricians
• Physicians involved in the out-patient management of COVID-19
• Refused to participate

Sponsors & Collaborators

• NMC Specialty Hospital: lead

Study Sites (1)

Reliance Hospital

Mumbai, Mumbai, Mahrastra, India

Location

Related Publications (4)

• Chandra A, Chakraborty U, Ghosh S, Dasgupta S. Anticoagulation in COVID-19: current concepts and controversies. Postgrad Med J. 2022 May;98(1159):395-402. doi: 10.1136/postgradmedj-2021-139923. Epub 2021 Apr 13.

  PMID: 33850011 BACKGROUND

• Fontelo P, Bastola MM, Zheng Z, Baik SH. A review of thromboembolic events in hospitalized COVID-19 patients. Thromb J. 2021 Jun 29;19(1):47. doi: 10.1186/s12959-021-00298-3.

  PMID: 34187490 BACKGROUND

• Jagiasi B, Nasa P, Chanchalani G, Ahmed A, Ak AK, Sodhi K, Mangal K, Singh MK, Gupta N, Bidkar PU, Tyagi RS, Khanikar RG, Tripathy S, Khanzode S, Subba Reddy K, Saigal S, Sivakumar VA, Javeri Y, Tekwani SS. Variation in therapeutic strategies for the management of severe COVID-19 in India: A nationwide cross-sectional survey. Int J Clin Pract. 2021 Oct;75(10):e14574. doi: 10.1111/ijcp.14574. Epub 2021 Jul 18.

  PMID: 34171154 BACKGROUND

• Liu Y, Cai J, Wang C, Jin J, Qu L. A systematic review and meta-analysis of incidence, prognosis, and laboratory indicators of venous thromboembolism in hospitalized patients with coronavirus disease 2019. J Vasc Surg Venous Lymphat Disord. 2021 Sep;9(5):1099-1111.e6. doi: 10.1016/j.jvsv.2021.01.012. Epub 2021 Jan 30.

  PMID: 33529719 BACKGROUND

MeSH Terms

Conditions

Thrombosis; Severe Acute Respiratory Syndrome; Pneumonia; COVID-19

Condition Hierarchy (Ancestors)

Embolism and Thrombosis; Vascular Diseases; Cardiovascular Diseases; Respiratory Tract Infections; Infections; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Virus Diseases; Respiratory Tract Diseases; Lung Diseases; Pneumonia, Viral

Study Officials

• Prashant Nasa, MD EDICM

  NMC Specialty Hospital, Dubai, UAE

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head Critical Care Medicine

Study Record Dates

• First Submitted: August 8, 2021
• First Posted: August 10, 2021
• Study Start: October 1, 2021
• Primary Completion: October 30, 2021
• Study Completion: November 10, 2021
• Last Updated: November 24, 2021

Record last verified: 2021-11

Data Sharing

• IPD Sharing: Will not share

Locations

IN (1)