Combined PENG and LFCN Block for Total Hip Arthroplasty

NCT04996290 | Completed

• 1 other identifier: B3002020000032
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

A clinical trial investigating the effect of a combined locoregional anesthesia technique on the postoperative analgesia outcomes after a total hip arthroplasty. A PENG block will be used in combination with a LFCN block. The results will be compared to a control group that is solely treated with intravenous analgesia. This technique aims to provide improved pain scores after surgery without interference of revalidation.

Conditions

Anesthesia, Conduction; Pain, Postoperative; Arthroplasty, Replacement, Hip

Keywords

regional anesthesia; postoperative pain; total hip arthroplasty; pericapsular nerve group block

Outcome Measures

Primary Outcomes (3)

• Initial pain score

  numeric rating score (NRS) of 0 to 10

  0 hours postoperative

• Pain score after 2h

  numeric rating score (NRS) of 0 to 10

  2 hours postoperative

• Pain score after 24h

  numeric rating score (NRS) of 0 to 10

  24 hours postoperative

Secondary Outcomes (5)

• Initial motor function

  0 hours postoperative

• Motor function after 2h

  2 hours postoperative

• Motor function after 24h

  24 hours postoperative

• Intraoperative opioids

  intraoperative

• Postoperative opioids

  24 hours postoperative

Study Arms (2)

PENG + LFCN block

ACTIVE COMPARATOR

The participants in this group received a combined regional technique just before surgery: * Pericapsular nerve group (PENG) block * Lateral femoral cutaneus nerve (LFCN) block

Procedure: PENG + LFCN block; Drug: Ropivacaine injection

No regional anesthesia

NO INTERVENTION

Control group

Interventions

PENG + LFCN block PROCEDURE

Regional anesthesia technique

Also known as: pericapsular nerve group block, lateral femoral cutaneous nerve block

PENG + LFCN block

Ropivacaine injection DRUG

Local anesthetic used for peripheral nerve block.

Also known as: ropivacaine 0.375%

PENG + LFCN block

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• adult patients who underwent a primary total hip replacement under general anesthesia

You may not qualify if:

• insulin dependent diabetes mellitus
• chronic pain
• severe dementia or mental retardation
• allergy to local anesthetics

Sponsors & Collaborators

• University Hospital, Antwerp: lead

Study Sites (1)

AZ Monica

Deurne, Belgium

Location

Related Publications (5)

• Giron-Arango L, Peng PWH, Chin KJ, Brull R, Perlas A. Pericapsular Nerve Group (PENG) Block for Hip Fracture. Reg Anesth Pain Med. 2018 Nov;43(8):859-863. doi: 10.1097/AAP.0000000000000847.

  PMID: 30063657 BACKGROUND

• Morrison C, Brown B, Lin DY, Jaarsma R, Kroon H. Analgesia and anesthesia using the pericapsular nerve group block in hip surgery and hip fracture: a scoping review. Reg Anesth Pain Med. 2021 Feb;46(2):169-175. doi: 10.1136/rapm-2020-101826. Epub 2020 Oct 27.

  PMID: 33109730 BACKGROUND

• Wainwright TW, Gill M, McDonald DA, Middleton RG, Reed M, Sahota O, Yates P, Ljungqvist O. Consensus statement for perioperative care in total hip replacement and total knee replacement surgery: Enhanced Recovery After Surgery (ERAS(R)) Society recommendations. Acta Orthop. 2020 Feb;91(1):3-19. doi: 10.1080/17453674.2019.1683790. Epub 2019 Oct 30.

  PMID: 31663402 BACKGROUND

• Roy R, Agarwal G, Pradhan C, Kuanar D. Total postoperative analgesia for hip surgeries, PENG block with LFCN block. Reg Anesth Pain Med. 2019 Mar 28:rapm-2019-100454. doi: 10.1136/rapm-2019-100454. Online ahead of print. No abstract available.

  PMID: 30923252 BACKGROUND

• Hojer Karlsen AP, Geisler A, Petersen PL, Mathiesen O, Dahl JB. Postoperative pain treatment after total hip arthroplasty: a systematic review. Pain. 2015 Jan;156(1):8-30. doi: 10.1016/j.pain.0000000000000003.

  PMID: 25599296 BACKGROUND

MeSH Terms

Conditions

Pain, Postoperative

Interventions

Ropivacaine

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Anilides; Amides; Organic Chemicals; Aniline Compounds; Amines

Study Officials

• Yzabel Vandevivere, MD

  AZ Monica

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: prospective randomized controlled trial

Study Record Dates

• First Submitted: July 19, 2021
• First Posted: August 9, 2021
• Study Start: June 1, 2020
• Primary Completion: September 30, 2020
• Study Completion: October 1, 2020
• Last Updated: August 9, 2021

Record last verified: 2021-08

Data Sharing

• IPD Sharing: Will not share

Locations

BE (1)