NCT02289937

Brief Summary

The purpose of this study was to evaluate the analgesic efficacy of the nervus cutaneous femoral lateralis (NCFL) blockade on postoperative pain after total hip replacement surgery. The NCFL-block is a pure sensory block. We hypothesized that the NCFL-block would reduced the postoperative pain without delaying mobilization.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
100

participants targeted

Target at P50-P75 for phase_4

Timeline
Completed

Started Mar 2014

Shorter than P25 for phase_4

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 1, 2014

Completed
7 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2014

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2014

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

November 10, 2014

Completed
3 days until next milestone

First Posted

Study publicly available on registry

November 13, 2014

Completed
Last Updated

November 13, 2014

Status Verified

November 1, 2014

Enrollment Period

7 months

First QC Date

November 10, 2014

Last Update Submit

November 12, 2014

Conditions

Keywords

Postoperative painregional anaesthesiatotal hip replacementnervus cutaneous femoral lateralis

Outcome Measures

Primary Outcomes (1)

  • VAS-score 4 hours postoperative during movement

    VAS-score 4 hours postoperative during 30 degrees of flexion of the hip. VAS-score: 0-100 mm; 0: no pain, 100: worst imaginable pain.

    4 hours postoperative

Secondary Outcomes (7)

  • VAS-score 0-24 hours postoperative during movement

    0-24 hours postoperatively

  • VAS-score 0-24 hours postoperative at rest

    0-24 hours postoperatively

  • Oxynorm consumption

    0-24 hours postoperative

  • time to first oxynorm requirement

    0-24 hours postoperatively

  • Mobilization

    0-24 hours postoperatively

  • +2 more secondary outcomes

Study Arms (2)

Ropivacaine

EXPERIMENTAL

8 ml of ropivacaine 7,5 mg/ml will be injected around nervus cutaneous femoral lateralis. Ultrasound-guided.

Drug: RopivacaineDevice: An ultrasound-guided Nervus cutaneous femoral lateralis blockade will be given postoperatively

Placebo

PLACEBO COMPARATOR

8 ml of isotonic saline will be injected around nervus cutaneous femoral lateralis. Ultrasound-guided

Drug: PlaceboDevice: An ultrasound-guided Nervus cutaneous femoral lateralis blockade will be given postoperatively

Interventions

Also known as: Naropin
Ropivacaine
Also known as: Saline, NaCl
Placebo

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Primary total hip replacement

You may not qualify if:

  • general anaesthesia
  • Allergy to local anesthetics of the amide type
  • Revision surgery
  • Bilateral surgery
  • Chronic pain patient
  • Women in the fertile age

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Pain, Postoperative

Interventions

RopivacaineSodium Chloride

Condition Hierarchy (Ancestors)

Postoperative ComplicationsPathologic ProcessesPathological Conditions, Signs and SymptomsPainNeurologic ManifestationsSigns and Symptoms

Intervention Hierarchy (Ancestors)

AnilidesAmidesOrganic ChemicalsAniline CompoundsAminesChloridesHydrochloric AcidChlorine CompoundsInorganic ChemicalsSodium Compounds

Study Officials

  • Daniel Hägi-Pedersen, M.D., Ph.D.

    Naestved Hospital, Department of Anaesthesiology

    STUDY CHAIR

Study Design

Study Type
interventional
Phase
phase 4
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Consultant

Study Record Dates

First Submitted

November 10, 2014

First Posted

November 13, 2014

Study Start

March 1, 2014

Primary Completion

October 1, 2014

Study Completion

October 1, 2014

Last Updated

November 13, 2014

Record last verified: 2014-11