NCT04993196

Brief Summary

T1rho imaging is a new MRI technique that has strong potential in neuroimaging. This technique does not require exogenous contrast agents and has high spatial resolution. In this study we aim to characterise the normal appearance of T1rho in the brain parenchyma in healthy participants. T1rho values will be measured in normal brain structures.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
30

participants targeted

Target at below P25 for not_applicable

Timeline
20mo left

Started Aug 2021

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress75%
Aug 2021Jan 2028

First Submitted

Initial submission to the registry

July 26, 2021

Completed
6 days until next milestone

Study Start

First participant enrolled

August 1, 2021

Completed
5 days until next milestone

First Posted

Study publicly available on registry

August 6, 2021

Completed
6.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 31, 2028

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 31, 2028

Last Updated

March 24, 2026

Status Verified

March 1, 2026

Enrollment Period

6.5 years

First QC Date

July 26, 2021

Last Update Submit

March 20, 2026

Conditions

Magnetic Resonance Imaging

Outcome Measures

Primary Outcomes (1)

  • T1rho value in normal grey and white matter in healthy volunteers

    T1rho value (measured on T1rho weighted MRI) in normal grey and white matter in healthy volunteers

    Up to 2 months

Study Arms (1)

T1rho MRI

EXPERIMENTAL
Diagnostic Test: T1rho imaging

Interventions

T1rho imagingDIAGNOSTIC_TEST

Magnetic Resonance Imaging using T1rho

T1rho MRI

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • \- Male and female volunteers greater than or equal to 18 years of age

You may not qualify if:

  • Subjects with a contraindication to magnetic resonance imaging such as the presence of metallic implants, claustrophobia and pregnancy.
  • Subjects with previous severe allergic or anaphylactoid reaction to a gadolinium contrast agent, or contraindication to contrast gadolinium administration, such severe renal disease or acutely deteriorating renal function, who would be at risk of nephrogenic systemic fibrosis
  • Subjects who are unable to tolerate the scan without moving the head as a result of symptoms such as tremor, spasticity, involuntary movements and spasms, cognitive impairment, coughing, and shortness of breath.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

CUHK

Hong Kong, Hong Kong

RECRUITING

Central Study Contacts

Tiffany So

CONTACT

+85235051035tiffanyso@cuhk.edu.hk

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
DIAGNOSTIC
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Clinical Assistant Professor

Study Record Dates

First Submitted

July 26, 2021

First Posted

August 6, 2021

Study Start

August 1, 2021

Primary Completion (Estimated)

January 31, 2028

Study Completion (Estimated)

January 31, 2028

Last Updated

March 24, 2026

Record last verified: 2026-03

Data Sharing

IPD Sharing
Will not share

Locations

HK(1)