BUILD
Understanding the Brain Basis of Language and Cognitive Functions Through the Study of Individuals With Brain Injury and Healthy Controls
Sponsor study identifier
Secondary identifiers
NIH
observational
400
1 country
1
Study Start
November 1, 2018
Actual (reported)Primary Completion
August 30, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
August 30, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Strokes often cause a loss of communication ability, referred to as aphasia, as well as cognitive difficulties. Each stroke survivor has a unique pattern of strengths and weaknesses in communication and cognition, and a unique course of recovery. The BUILD study aims to understand the brain basis of these individual differences in stroke outcome. Participants with stroke as well as controls matched in age, educational background, race, and sex are examined using a combination of standardized and in-house tests of language and cognition to provide a detailed profile of strengths and weaknesses. Each participant will have between three and six sessions, including an MRI to measure details of the structure, function, and connections in the brain. The data are analyzed to test how patterns in the stroke lesion explain the patterns of communication and cognitive difficulties, and how patterns in the uninjured parts of the brain explain resilience and recovery from the stroke. Ultimately, we hope that BUILD will guide us toward new targets for brain stimulation treatments or other biologically based treatments that improve language and cognitive abilities after stroke.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
August 30, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
November 1, 2018
Actual (reported)July 1, 2021
Actual (reported)August 5, 2021
Actual (reported)August 30, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
August 30, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
MP-RAGE (Magnetization Prepared Rapid Acquisition Gradient Echo)
Part of MRI sequence that measures deep grey matter structure.
Collected within 1 month of behavioral testing
DTI (Diffusion Tensor Imaging)
Part of MRI sequence that measures the rate of water diffusion between cells to understand and create a map of internal structures.
Collected within 1 month of behavioral testing
Behavioral testing
Battery of standard clinical and in-house behavioral tests to measure speech, language, and cognition. Final score is derived from principle components analysis.
Collected within 1 month of MRI
Participants have had a left-hemisphere stroke with or without aphasia, or a stroke elsewhere in the brain causing aphasia. They are given a series of standardized and in-house tests of language and cognition to provide a detailed profile of strengths and weaknesses, plus an MRI.
Participants are matched to aphasia cohort in age, educational background, race, and gender but have no history of brain injury. They are also given a series of standardized and in-house tests of language and cognition to provide a detailed profile of strengths and weaknesses, plus an MRI.
Participants are survivors of left hemisphere stroke with or without aphasia, or people with aphasia due to strokes in other parts of the brain. We recruit participants primarily from the Washington, DC region, but some participants may travel from farther away to participate in the study. We aim for our participants to be fully representative of the diversity of individuals with stroke in the general population. Control participants are matched to stroke survivors on age, gender, race, educational background, and stroke risk factors.
Georgetown University Medical Center
Washington D.C., District of Columbia, 20057, United States
Vladyko N, DeMarco AT, Turkeltaub PE. Right Hemisphere Functional Connectivity Increases in Proportion to Left Hemisphere Lesion Size, but Not Within the Language Network. Hum Brain Mapp. 2026 Sep;47(13):e70631. doi: 10.1002/hbm.70631.
Peter Turkeltaub, MD,PhD
Georgetown University; MedStar National Rehabilitation Hospital
First Submitted
July 1, 2021
First Posted
August 5, 2021
Study Start
November 1, 2018
Actual (reported)Primary Completion
August 30, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Transcranial Alternating Current Stimulation (tACS) in Aphasia
Contact the study team to confirm eligibility.
Study Completion
August 30, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
November 12, 2024
Record last verified: 2024-04
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Source: ClinicalTrials.gov.
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