Electronic Quitline Referral With Enhanced Academic Detailing for the Promotion of Smoking Cessation

NCT04969978 | Active Not Recruiting

• 3 other identifiers: STUDY00023019NCI-2021-06581R01CA255016
• Study Type: interventional
• Target: 9,133
• Locations: 1 country
• Sites: 1

Brief Summary

This phase IV clinical trial determines the impact of implementing a Quitline electronic (e)Referral system with an enhanced academic detailing implementation strategy on Quitline reach, tobacco cessation assistance and self-reported quit rates among patients in community health centers. It also examines the cost-effectiveness of Quitline eReferrals both with and without enhanced academic detailing. If this implementation strategy is effective, this strategy could be used to increase tobacco cessation treatment through the collaboration between state Quitlines and community health centers that serve large numbers of socioeconomically disadvantaged patients who use tobacco.

Conditions

Tobacco-Related Carcinoma; Smoking &Amp; Tobacco Cessation

Outcome Measures

Primary Outcomes (1)

• Accepted electronic (e)Referral to Quitline

  Proportion of patients who accepted a Quitline eReferral in intervention (EAD) versus comparator clinics. Will use a logistic mixed effects model that addresses the following design features of the study: 1) will include random intercept for clinic to account for clustering of patients within clinics; 2) will perform an intent-to-treat analysis; 3) hypothesis tests will be two-sided.

  At any point during the 24-month intervention period

Secondary Outcomes (8)

• Quitline eReferral offered

  At any point during the 24-month intervention period

• Quitline enrollment

  At any point during the 24-month intervention period

• Receipt of in-office counseling

  At any point during the 24-month intervention period

• Tobacco cessation medication ordered

  At any point during the 24-month intervention period

• Tobacco cessation

  At any point during the 24-month intervention period or up to 6 months post-intervention

Other Outcomes (1)

• Tobacco use assessed

  At any point during the 24-month intervention period

Study Arms (2)

Arm I (Quitline eReferral)

ACTIVE COMPARATOR

Clinics are notified via email that the Quitline eReferral system is available with a link to an online publication that includes an overview of Quitline services, information on Quitline effectiveness, and a detailed eReferral workflow with corresponding EHR screenshots, including how to identify eligible patients, create an eReferral, and access Quitline follow-up data in the EHR. Clinics also gain access to technological assistance, as needed.

Other: Informational Intervention

ARM II (Quitline eReferral plus enhanced AD)

EXPERIMENTAL

Clinics receive standard online materials access to remote technological assistance as in Arm I. Clinics also receive group training of clinic staff prior to activation of the eReferral system and 12 months post-activation, follow-up booster sessions and monthly performance audit and feedback.

Behavioral: Enhanced Academic Detailing; Other: Informational Intervention

Interventions

Enhanced Academic Detailing BEHAVIORAL

* Group training of clinic staff prior to activation of the eReferral system and 12 months post-activation * Follow-up booster sessions * Monthly performance audit and feedback

Also known as: EAD

ARM II (Quitline eReferral plus enhanced AD)

Informational Intervention OTHER

Receive overview of Quitline services and use of Quitline eReferral via online materials

ARM II (Quitline eReferral plus enhanced AD); Arm I (Quitline eReferral)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• In Oregon
• On the OCHIN Epic EHR for \>= 1 year
• Willing to be randomized to the intervention or comparison condition
• Willing to recruit a provider to serve as a clinic champion (to share monthly performance audit and feedback at all-staff meetings, determine desired content of booster sessions with clinic team members, and complete a survey at the completion of the intervention period) and a clinic manager to coordinate training and booster sessions
• Adult patients (\>= 18 years of age)
• Identified as current tobacco users during \>= 1 ambulatory and/or telehealth visit to one of the eligible study clinics over the 24-month study period

Sponsors & Collaborators

• OHSU Knight Cancer Institute: lead
• OCHIN, Inc.: collaborator
• Kaiser Permanente: collaborator
• Oregon Health and Science University: collaborator
• National Cancer Institute (NCI): collaborator

Study Sites (1)

OHSU Knight Cancer Institute

Portland, Oregon, 97239, United States

Location

MeSH Terms

Conditions

Smoking; Tobacco Use Cessation

Condition Hierarchy (Ancestors)

Behavior; Health Behavior

Study Officials

• Steffani Bailey

  OHSU Department of Family Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: July 9, 2021
• First Posted: July 21, 2021
• Study Start: June 20, 2023
• Primary Completion: August 22, 2025
• Study Completion: February 22, 2026
• Last Updated: January 28, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)