Nicotine and Tobacco Message Framing to Change Smoking Behavior in Diverse Groups of Young Adult Smokers

NCT06644664 | Completed DMC

• 3 other identifiers: OSU-23436NCI-2024-04955R00CA260718
• Study Type: interventional
• Target: 292
• Locations: 1 country
• Sites: 1

Brief Summary

This clinical trial evaluates the effect of message framing on smoking behaviors among lesbian, gay, bisexual, transgender, queer (LGBTQ+) young adults who use nicotine and/or tobacco. Tobacco regulation has contributed to a steady decline in tobacco products designed to be smoked (combustible), but there has been an increase in the use of new tobacco products, such as electronic nicotine delivery systems (ENDS). The use of more than one tobacco product (polytobacco) is high in LGBTQ+ populations. Both LGBTQ+ people and people who engage in polytobacco use are less likely to view tobacco as harmful, which may reinforce tobacco use. Message framing includes culturally targeted messages to communicate the absolute risks (AR) and relative risks (RR) of polytobacco use. Using message framing may increase quit rates or change smoking behaviors in LGBTQ+ young adults who use nicotine and/or tobacco products.

Conditions

Tobacco-Related Carcinoma

Keywords

Sexual and Gender Minorities; Health Communication; Tobacco Products; Cigarettes; Electronic Nicotine Delivery Systems; E-cigarettes; young adult; text messaging

Outcome Measures

Primary Outcomes (3)

• Total tobacco cessation

  2 items. Asks for current use of nicotine vapes and combustible cigarettes Every day, Some days, or Not at all.

  At 12 weeks post-baseline

• Acceptability of multimedia messaging service (MMS) anti-polytobacco messages

  In a qualitative interview, Participants will be asked the following question: How did you find participating in a study with images sent via text message? How smoothly would you say it went?

  At 6-week post-enrollment

• Feasibility of MMS anti-polytobacco messages

  6 items per study arm. Experimental arms 1 and 2: 6 Yes/No questions (1 per week) checking for engagement with the study content, specifically regarding nicotine and tobacco use. Control Group: 6 Yes/No questions (1 per week) checking for engagement with the study content, specifically regarding sun safety.

  At 6-weeks post-enrollment

Secondary Outcomes (4)

• Switching to exclusive electronic nicotine delivery system (ENDS) use

  At 6- and 12-weeks post-baseline

• Risk perceptions

  At 6- and 12-weeks post-baseline

• Behavioral intentions

  Difference between conditions in behavioral intentions from screener, and at 6 and 12-week post baseline

• Serious quit attempts

  Difference between conditions in quit attempts from screener, and at 6 and 12-week post baseline

Study Arms (3)

Arm I (Absolute Risk messages)

EXPERIMENTAL

Participants receive AR anti-polytobacco MMS messages TIW and a check-in text message QW for a total of 6 weeks. Participants also receive smoking cessation resources via email during follow up.

Other: Interview; Behavioral: Smoking Cessation Intervention; Other: Survey Administration; Other: Text Message-Based Navigation Intervention

Arm II (Relative Risk messages)

EXPERIMENTAL

Participants receive RR anti-polytobacco MMS messages TIW and a check-in text message QW for a total of 6 weeks. Participants also receive smoking cessation resources via email during follow up.

Other: Interview; Behavioral: Smoking Cessation Intervention; Other: Survey Administration; Other: Text Message-Based Navigation Intervention

Arm III (control messages)

ACTIVE COMPARATOR

Participants receive control MMS messages on health risks of UV/sun exposure TIW and a check-in text message QW for a total of 6 weeks. Participants also receive smoking cessation resources via email during follow up.

Behavioral: Health Education; Behavioral: Smoking Cessation Intervention; Other: Survey Administration; Other: Text Message-Based Navigation Intervention

Interventions

Health Education BEHAVIORAL

Receive control MMS messages

Arm III (control messages)

Interview OTHER

Ancillary studies

Arm I (Absolute Risk messages); Arm II (Relative Risk messages)

Smoking Cessation Intervention BEHAVIORAL

Receive AR MMS messages

Also known as: Smoking and Tobacco Use Cessation Interventions

Arm I (Absolute Risk messages)

Survey Administration OTHER

Ancillary studies

Arm I (Absolute Risk messages); Arm II (Relative Risk messages); Arm III (control messages)

Text Message-Based Navigation Intervention OTHER

Receive check-in text message

Also known as: Automated Text Message-Based Navigation, Text Message-Based Navigation

Arm I (Absolute Risk messages); Arm II (Relative Risk messages); Arm III (control messages)

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• years old
• Self-identify as LGBTQ+
• Able to speak English fluently
• An ever user of ENDS and combustible tobacco who currently use ENDS, combustible cigarettes, or both ENDS and combustible cigarettes
• Currently reside in the United States (US)
• Have a mobile phone through a U.S. carrier with MMS messaging and can send and receive text messages for study participation
• Access to the internet with Zoom capabilities

You may not qualify if:

• Have a landline or Voice Over Internet Protocol (VOIP) phone number

Sponsors & Collaborators

• Ohio State University Comprehensive Cancer Center: lead
• National Cancer Institute (NCI): collaborator

Study Sites (1)

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States

Location

Related Links

• Our Health Matters

MeSH Terms

Conditions

Coitus; Vaping

Interventions

Interviews as Topic; Smoking Devices

Condition Hierarchy (Ancestors)

Sexual Behavior; Behavior; Smoking

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health; Manufactured Materials; Technology, Industry, and Agriculture

Study Officials

• Joanne G Patterson

  Ohio State University Comprehensive Cancer Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: Participants are blinded to their randomization category (absolute risks, relative risks, or control)
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: October 15, 2024
• First Posted: October 16, 2024
• Study Start: September 24, 2024
• Primary Completion: February 2, 2026
• Study Completion: February 2, 2026
• Last Updated: March 30, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)