Recovery and Muscle Function After Supplementation With Turmeric

NCT04946981 | Completed

• 1 other identifier: AFCRO-128
• Study Type: interventional
• Target: 45
• Locations: 1 country
• Sites: 1

Brief Summary

The objective of the study is to test the capacity of a five-day supplementation of Turmipure Gold® to improve exercise-induced muscle pain and function recovery in moderately active adults after exercise-induced muscle damage

Conditions

Muscle Soreness; Pain; Muscle Damage

Keywords

Turmeric; Curcuminoids; Sport performance & recovery

Outcome Measures

Primary Outcomes (1)

• Change on Perceived Muscle Soreness

  Perceived Muscle Soreness in quadriceps during squatting activities assessed by VAS (0-100 mm, after two tries)

  72 hours

Secondary Outcomes (7)

• Change on Muscle damage

  72 hours

• Change on Isometric Muscle function recovery

  72 hours

• Change on Isokinetic Muscle function recovery

  72 hours

• Change on Muscle power recovery

  72 hours

• Change on Muscle ROM recovery

  72 hours

Study Arms (2)

Randomized Crossover_Sequence 1

OTHER

Participants who meet the eligibility criteria will be randomized and will receive first the experimental product Turmipure GOLD® during the first study phase and then the placebo control during the second study phase. Both study phases are separated by a washout period of minimum 14 days.

Dietary Supplement: Turmipure Gold®; Dietary Supplement: Placebo

Randomized Crossover_Sequence 2

OTHER

Participants who meet the eligibility criteria will be randomized and will receive first the placebo control during the first study phase and then the experimental product Turmipure GOLD® during the second study phase. Both study phases are separated by a washout period of minimum 14 days.

Dietary Supplement: Turmipure Gold®; Dietary Supplement: Placebo

Interventions

Turmipure Gold® DIETARY_SUPPLEMENT

TPG: Turmipure GOLD® - 1 capsule per day - as prescribed

Randomized Crossover_Sequence 1; Randomized Crossover_Sequence 2

Placebo DIETARY_SUPPLEMENT

Placebo: colored acacia gum - 1 capsule per day - as prescribed

Randomized Crossover_Sequence 1; Randomized Crossover_Sequence 2

Eligibility Criteria

• Age: 25 Years - 45 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy free-living males
• Age: 25-45 years old
• Have a BMI between 18.5 and 28 kg/m²
• Moderately active with running 15-20 km per week
• With 1 to 4h of training per week, with maximum 1h of lower body heavy-load or resistance training (e.g., Hill running or hiking, HIT exercise, Squats, Lunges, Leg-press, Bench steps, etc.)
• Consent to the study protocol and to comply with study product
• Willing to limit caffeine, smoking, and alcohol consumption during the entire study period with no more than 5 cigarettes per day and 2 drinks. Also, alcohol consumption will not be allowed 24hours prior to exercise-induced muscular damage
• Willing to refrain from training for 3 days before the first test, 5 days before each damage-inducing exercise and during each supplementation phase, including active recovery exercises such as swimming, cycling at low intensity, unusual distance walking (however such should be encouraged during the 14 days wash-out)
• Willing to refrain the use of anti-inflammatory/pain reliever drugs such as paracetamol, NSAIDs, etc., during each supplementation phase, from 24 hours prior to 72 hours following the exercise-induced muscular damage
• Willing to refrain from 'recovery' treatments over the 72 hours following the damage inducing exercise such as:
• Hydrotherapy - cold water immersion, hot water immersion, or contrast therapy (as well as Jacuzzis, Steam baths, or Saunas)
• Massage - self, foam rolling, etc.
• Stretching
• Compression garments
• Topical applications - Tiger Balm, Deep Heat etc.

You may not qualify if:

• Participants with any indicators of arthritis, joint disorders chronic pain syndrome, muscle disorder diseases (e.g., fibromyalgia, etc.)
• History of surgery or significant injury in joints or in the lower limb in the last six months prior to study enrolment, or an anticipated need for surgical or invasive procedure that will be performed during the study
• Using omega-3-fatty acid, probiotic supplements, vitamins, minerals, or any dietary supplements (including botanicals), especially to maintain joint health 4 weeks prior to screening and during the entire study. Potential supplements include but are not limited to Beta-alanine, Creatine, HMB, Carnosine, Taurine, androstenedione, DHEA, Whey protein, or a pre-workout supplement
• Following any specific diet such as high-protein, vegetarian, vegan, etc
• Taking any drugs such as antibiotics, laxatives, or immunosuppressant drugs
• History of glucocorticoid injection or hyaluronic acid injections within 3 months prior to enrolment
• Participants near or in the peak of training for an athletic race (half or marathon, cycling tour or triathlon)
• History or current significant cardiovascular, pulmonary, renal, liver, digestive (including an inflammatory bowel disease), infectious disease, systemic disease, immune disorder, or metabolic/endocrine disorders (including diabetes mellitus) or other disease that would preclude supplement ingestion and/or assessment of study objectives, including uncontrolled hypertension, uncontrolled thyroidism or lipidaemia that is not on stable medication for at least 3 months.
• Participant has any concurrent medical or psychiatric condition that, in the opinion of the Investigator, would compromise his/her ability to comply with the study requirements
• Participant with history of drug and / or alcohol abuse at the time of enrolment
• Any previous or current cancer diagnosis (including a benign or malign tumour of intestine or colon)
• Current illnesses which could interfere with the study (e.g., prolonged severe diarrhoea, regurgitation/severe, difficulty swallowing)
• Known allergy to components of the test product or sensitivity to herbal products or with a medical history of food allergies
• Participants taking any anticoagulant or heparin treatment (including aspirin)
• Clinically significant abnormal laboratory results at screening

Sponsors & Collaborators

• Givaudan France Naturals: lead
• Atlantia Food Clinical Trials: collaborator

Study Sites (1)

Atlantia Food Clinical Trials

Cork, T23 R50R, Ireland

Location

Related Publications (1)

• Schonenberger KA, Laval J, Woods T, Truillet R, Naranjo-Modad S, Mettler S, Fanca-Berthon P. A randomized, placebo-controlled, crossover clinical trial to evaluate the effect of a turmeric formulation on muscle soreness and function recovery in moderately active adults. J Int Soc Sports Nutr. 2025 Dec;22(1):2568048. doi: 10.1080/15502783.2025.2568048. Epub 2025 Oct 3.

  PMID: 41040018 DERIVED

MeSH Terms

Conditions

Myalgia; Pain

Condition Hierarchy (Ancestors)

Muscular Diseases; Musculoskeletal Diseases; Neuromuscular Diseases; Nervous System Diseases; Musculoskeletal Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Timothy Dinan, Professor

  Atlantia Food Clinical Trials

  PRINCIPAL INVESTIGATOR

• Trevor Wood, PhD

  Sport Physiologist University College Cork

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 21, 2021
• First Posted: July 1, 2021
• Study Start: July 12, 2021
• Primary Completion: April 1, 2022
• Study Completion: April 1, 2022
• Last Updated: December 12, 2022

Record last verified: 2022-12

Locations

IE (1)