NCT04946305

Brief Summary

This is a prospective, open-label, multi-center, non-comparative, non-interventional observational study to assess safety and effectiveness of Lutathera in patients with somatostatin receptor-positive GEP-NET in the real-world setting in Korea.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
89

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started May 2022

Typical duration for all trials

Geographic Reach
1 country

6 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 23, 2021

Completed
7 days until next milestone

First Posted

Study publicly available on registry

June 30, 2021

Completed
10 months until next milestone

Study Start

First participant enrolled

May 10, 2022

Completed
2.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 8, 2024

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 8, 2024

Completed
Last Updated

August 9, 2024

Status Verified

August 1, 2024

Enrollment Period

2.2 years

First QC Date

June 23, 2021

Last Update Submit

August 8, 2024

Conditions

Keywords

somatostatin receptor-positive GEP-NETLutatheraObservationalprospective

Outcome Measures

Primary Outcomes (2)

  • Incidence of Adverse Events

    Incidence of Adverse Events (AEs), Serious AE and unexpected AEs.

    Up to 36 weeks

  • Incidence of Adverse Drug Reactions

    Incidence of Adverse Drug Reactions (ADRs), Serious ADRs and unexpected ADRs.

    Up to 36 weeks

Secondary Outcomes (1)

  • Effectiveness in terms of Overall Response Rate (ORR)

    Up to 32 weeks (4 cycles of 8 weeks)

Study Arms (1)

Lutathera

Patients administered Lutathera by prescription

Other: Lutathera

Interventions

Prospective observational study. There is no treatment allocation. Patients administered Lutathera by prescription that have started before inclusion of the patient into the study will be enrolled.

Lutathera

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients with somatostatin receptor-positive GEP-NET in the real-world setting in Korea.

You may qualify if:

  • Patients who start Lutathera treatment per clinical judgment, according to the locally approved labeling.
  • \- somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in adults.
  • Patients who are willing to provide written informed consent.

You may not qualify if:

  • \. Patients with contraindication according to prescribing information for Lutathera in Korea.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (6)

Novartis Investigative Site

Seongnam-si, Gyeonggi-do, 13620, South Korea

Location

Novartis Investigative Site

Seoul, 03722, South Korea

Location

Novartis Investigative Site

Seoul, 06351, South Korea

Location

Novartis Investigative Site

Seoul, 110-799, South Korea

Location

Novartis Investigative Site

Seoul, 137-040, South Korea

Location

Novartis Investigative Site

Seoul, 138-736, South Korea

Location

MeSH Terms

Interventions

lutetium Lu 177 dotatate

Study Officials

  • Novartis Pharmaceuticals

    Novartis Pharmaceuticals

    STUDY DIRECTOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 23, 2021

First Posted

June 30, 2021

Study Start

May 10, 2022

Primary Completion

July 8, 2024

Study Completion

July 8, 2024

Last Updated

August 9, 2024

Record last verified: 2024-08

Data Sharing

IPD Sharing
Will not share

Locations