The Effect of Joint Hypermobility Syndrome on Delayed Onset of Muscle Soreness and Recovery Time

NCT04934267 | Unknown DMC

• 1 other identifier: BHS-1636
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of the study is to investigate Joint Hypermobility Syndrome (JHS) and its effect on delayed onset muscle soreness (DOMS) and recovery time. The hypothesis is that people with JHS will experience increased DOMS when compared to non-hypermobile people. The results this study may assist and add to the body of knowledge when treating and exercising patients with JHS, as considerations can possibly be made when treating this population. Subjects with JHS may experience greater DOMS and require more time to recover between treatment sessions.

Conditions

Hypermobility Syndrome

Keywords

DOMS; Hypermobility,; Recovery

Outcome Measures

Primary Outcomes (5)

• "Change" is being assessed in Girth between the 5 time points

  Girth is the measurement of the circumference of a limb in centimetres, measuring edema, which commonly occurs during DOMS.

  Baseline (Day 1) through Day 2,3,4 and 5.

• "Change' is being assessed in Resting arm angle (RANG)between the 5 time points,

  Resting Arm Angle (RANG) is a Range Of Motion measurement in degrees of the arm while resting

  Baseline (Day 1) through Day 2,3,4 and 5.

• "Change" is being assessed in Visual Analogue Scale (VAS) of Pain between the 5 time points

  The VAS is a simple pain scale ranging from 0-100 mm, 0 being no pain and 100 mm being the worst pain the participant has felt.

  Baseline (Day 1) through Day 2,3,4 and 5.

• "Change" is being assessed in The McGill Pain Questionnaire (SF-MQ2)between the 5 time points

  The McGill Pain Questionnaire (SF-MQ2) is a questionnaire that allows the participant to rate their pain.

  Baseline (Day 1) through Day 2,3,4 and 5.

• "Change" is being assessed in Algometer pain pressure threshold between the 5 time points

  the pressure pain threshold using an algometer is done by applying continuous ascending pressure at a constant rate on their self reported most painful area surrounding the elbow in order to quantify the individuals pain pressure threshold, measured in kg.

  Baseline (Day 1) through Day 2,3,4 and 5.

Study Arms (1)

Eccentric exercise of elbow in order to induce Delayed Onset of Muscle Soreness

EXPERIMENTAL

There will be two groups, an experimental group with hypermobile individuals, and a control group with individuals that are not hypermobile with normal ranges of motion. All participants will take part in an exercise session with eccentric bicep curls based on their 1 repetition maximum (1RM).Both groups will perform 1 set of standing eccentric bicep curls based on their 1RM to failure in order to induce DOMS.The exercise will stop when the participant cannot volitionally keep up with the 5 second count lowering the weight. Prior to exercise, baseline measurements will be taken for all dependent variables. These measures will be taken every day at the same time of day,for the next 4 days.

Other: Eccentric Exercise for subjects with JHS; Other: Eccentric Exercise for Controls

Interventions

Eccentric Exercise for subjects with JHS OTHER

There will be two groups, an experimental group with hypermobile individuals, and a control group with individuals that are not hypermobile with normal ranges of motion. All participants will take part in an exercise session with eccentric bicep curls based on their 1 repetition maximum (1-RM), which is the highest amount of weight that they can lift concentrically once. The independent variables are the two groups and the dependent variables are girth, resting arm angle, Pain, McGill Pain Questionnaire, and pressure pain threshold. This groups will perform 1 set of standing eccentric bicep curls order to induce DOMS.Each rep will include a timed 5 second long eccentric component without an concentric component,. The exercise will stop when the participant cannot volitionally keep up with the 5 second count. Prior to exercise, baseline measurements will be taken for all dependent variables. These measures will be taken every day at the same time of day,for the next 4 days.

Eccentric exercise of elbow in order to induce Delayed Onset of Muscle Soreness

Eccentric Exercise for Controls OTHER

There will be two groups, an experimental group with hypermobile individuals, and a control group with individuals that are not hypermobile with normal ranges of motion. All participants will take part in an exercise session with eccentric bicep curls based on their 1 repetition maximum (1-RM), which is the highest amount of weight that they can lift concentrically once. The independent variables are the two groups and the dependent variables are girth, resting arm angle, Pain, McGill Pain Questionnaire, and pressure pain threshold. This groups will perform 1 set of standing eccentric bicep curls order to induce DOMS.Each rep will include a timed 5 second long eccentric component without an concentric component,. The exercise will stop when the participant cannot volitionally keep up with the 5 second count. Prior to exercise, baseline measurements will be taken for all dependent variables. These measures will be taken every day at the same time of day,for the next 4 days.

Eccentric exercise of elbow in order to induce Delayed Onset of Muscle Soreness

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age range: 18-35 years
• Good overall health
• Regularly participate in recreational exercise
• subjects with normal ranges of motion (score of \<4 on Beighton Scale), 10 subjects with increased ranges of motion (score of \>4 on Beighton Scale AND hypermobile in the elbow)

You may not qualify if:

• Individuals with Ehler-Danlos Syndrome.
• Any major musculoskeletal injuries in the last 6 months.
• Any recent traumas that could lead to acute hypermobility or instabilities
• Any known disorders that impede recovery/healing time (i.e. Lupus, Rheumatoid Arthritis, Scleroderma).
• Any other health issues that would risk the safety of the subject.

Sponsors & Collaborators

• New York Institute of Technology: lead

Study Sites (1)

New York Institute of Technology

Old Westbury, New York, 11568, United States

RECRUITING

Related Publications (5)

• Tinkle BT, Levy HP. Symptomatic Joint Hypermobility: The Hypermobile Type of Ehlers-Danlos Syndrome and the Hypermobility Spectrum Disorders. Med Clin North Am. 2019 Nov;103(6):1021-1033. doi: 10.1016/j.mcna.2019.08.002.

  PMID: 31582002 BACKGROUND

• Lee H, Petrofsky JS, Laymon M, Yim J. A greater reduction of anterior cruciate ligament elasticity in women compared to men as a result of delayed onset muscle soreness. Tohoku J Exp Med. 2013 Oct;231(2):111-5. doi: 10.1620/tjem.231.111.

  PMID: 24107654 BACKGROUND

• Castori M, Morlino S, Celletti C, Celli M, Morrone A, Colombi M, Camerota F, Grammatico P. Management of pain and fatigue in the joint hypermobility syndrome (a.k.a. Ehlers-Danlos syndrome, hypermobility type): principles and proposal for a multidisciplinary approach. Am J Med Genet A. 2012 Aug;158A(8):2055-70. doi: 10.1002/ajmg.a.35483. Epub 2012 Jul 11.

  PMID: 22786715 BACKGROUND

• Terry RH, Palmer ST, Rimes KA, Clark CJ, Simmonds JV, Horwood JP. Living with joint hypermobility syndrome: patient experiences of diagnosis, referral and self-care. Fam Pract. 2015 Jun;32(3):354-8. doi: 10.1093/fampra/cmv026. Epub 2015 Apr 24.

  PMID: 25911504 BACKGROUND

• Douris P, Southard V, Ferrigi R, Grauer J, Katz D, Nascimento C, Podbielski P. Effect of phototherapy on delayed onset muscle soreness. Photomed Laser Surg. 2006 Jun;24(3):377-82. doi: 10.1089/pho.2006.24.377.

  PMID: 16875447 BACKGROUND

Study Officials

• Peter C Douris, EdD

  New York Institute of Technology

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Peter C Douris, EdD

CONTACT

5162486332; pdouris@nyit.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: Comparing the recovery times and length of DOMS in individuals with JHS to individuals with normal ranges of motion in response to exercise

Study Record Dates

• First Submitted: May 19, 2021
• First Posted: June 22, 2021
• Study Start: May 1, 2021
• Primary Completion: May 1, 2022
• Study Completion: May 15, 2022
• Last Updated: November 2, 2021

Record last verified: 2021-11

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)