Microstructure of Ingestive Behavior and Body Weight Loss After Roux-en-Y Gastric Bypass

NCT04933305 | Completed

• 1 other identifier: 2017-00756
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Studies of appetitive behavior in humans after RYGB have produced ambiguous results. It therefore remains unclear whether there are fundamental shifts in the palatability of high-fat and sugary foods after RYGB or simply a decrease in the appetitive drive to ingest them. Moreover, learning processes may play a role as changes in diet selection progress with time in rats after RYGB. However, direct measures of an altered food selection in humans after RYGB are rare and both the durability of the phenomenon as well as the role of experience for changes in food selection remain elusive.

Conditions

Obesity; Food Deprivation; Bariatric Surgery; Roux-en-y Gastric Bypass; Ingestive Microstructure; Ingestive Behavior; Drinkometer

Outcome Measures

Primary Outcomes (1)

• Correlation between microstructure of ingestive behavior and body weight loss

  Pearson correlation coefficient for the linear relationship between microstrutural parameters of ingestive behavior and body weight loss one year after RYGB surgery

  one year after surgery

Secondary Outcomes (1)

• Stability of the microstructure of ingestive behavior

  fourteen days

Study Arms (1)

RYGB patients

Patients that already received RYGB one year prior commencement of their participation in the study

Procedure: Roux-en-Y Gastric Bypass

Interventions

Roux-en-Y Gastric Bypass PROCEDURE

Laparoscopic surgical procedure

RYGB patients

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult females with severe obesity that underwent RYGB

You may qualify if:

• received RYGB
• ability to provide inform consent

You may not qualify if:

• lactose intolerance
• diabetes
• immunosuppression
• pregnancy / lactation
• use of weight-loss medication
• history of previous visceral surgery

Sponsors & Collaborators

• Marco Bueter: lead
• Dr. Alan Spector, Florida State University, Department of Psychology: collaborator

Study Sites (1)

University Hospital Zurich

Zurich, 8091, Switzerland

Location

Related Publications (5)

• Gero D, File B, Justiz J, Steinert RE, Frick L, Spector AC, Bueter M. Drinking microstructure in humans: A proof of concept study of a novel drinkometer in healthy adults. Appetite. 2019 Feb 1;133:47-60. doi: 10.1016/j.appet.2018.08.012. Epub 2018 Sep 1.

  PMID: 30179650 BACKGROUND

• Gero D, Steinert RE, le Roux CW, Bueter M. Do Food Preferences Change After Bariatric Surgery? Curr Atheroscler Rep. 2017 Sep;19(9):38. doi: 10.1007/s11883-017-0674-x.

  PMID: 28779431 BACKGROUND

• Mathes CM, Bohnenkamp RA, Blonde GD, Letourneau C, Corteville C, Bueter M, Lutz TA, le Roux CW, Spector AC. Gastric bypass in rats does not decrease appetitive behavior towards sweet or fatty fluids despite blunting preferential intake of sugar and fat. Physiol Behav. 2015 Apr 1;142:179-88. doi: 10.1016/j.physbeh.2015.02.004. Epub 2015 Feb 3.

  PMID: 25660341 BACKGROUND

• Spector AC, Klumpp PA, Kaplan JM. Analytical issues in the evaluation of food deprivation and sucrose concentration effects on the microstructure of licking behavior in the rat. Behav Neurosci. 1998 Jun;112(3):678-94. doi: 10.1037//0735-7044.112.3.678.

  PMID: 9676983 BACKGROUND

• Johnson AW. Characterizing ingestive behavior through licking microstructure: Underlying neurobiology and its use in the study of obesity in animal models. Int J Dev Neurosci. 2018 Feb;64:38-47. doi: 10.1016/j.ijdevneu.2017.06.012. Epub 2017 Jul 3.

  PMID: 28684308 BACKGROUND

MeSH Terms

Conditions

Obesity; Feeding Behavior

Interventions

Gastric Bypass

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior, Animal; Behavior

Intervention Hierarchy (Ancestors)

Bariatric Surgery; Bariatrics; Obesity Management; Therapeutics; Gastroenterostomy; Anastomosis, Surgical; Surgical Procedures, Operative; Digestive System Surgical Procedures

Study Officials

• Marco Bueter, MD, DPhil

  University of Zurich

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Assistant Professor, PhD, Head of Bariatric and Endocrine Surgery

Study Record Dates

• First Submitted: June 15, 2021
• First Posted: June 21, 2021
• Study Start: April 1, 2019
• Primary Completion: July 25, 2020
• Study Completion: June 4, 2021
• Last Updated: August 18, 2023

Record last verified: 2023-08

Data Sharing

• IPD Sharing: Will not share

Locations

CH (1)