Changes in Food Preference and Food Cue Responsivity After Bariatric Surgery

NCT02068001 | Unknown

• 1 other identifier: NL45837.081.13
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 3

Brief Summary

It has been suggested that obese people are more sensitive to sensory and rewarding effects of food, aspects that mediate food preferences and intake. Individuals that underwent Roux-en-Y gastric bypass surgery frequently report changes in food preference. They indicate a decreased preference for highly rewarding energy dense foods. Changes in food preference might be related to alterations in central (brain) mechanisms, related to reward sensing. The smell and sight of food can be considered as anticipatory cues for the rewarding effects of food intake. The aim of this study is to determine the effect of gastric bypass surgery on (alterations in) food preferences. Secondly, this study aims at assessing the effect of gastric bypass surgery on the brain reward response when exposed to sight and smell of food stimuli with different sugar and fat contents.

Conditions

Roux-en-Y Gastric Bypass

Outcome Measures

Primary Outcomes (2)

• Development of food preferences after Roux-en-Y gastric bypass surgery

  Food preferences will be assessed 2 weeks before Roux-en-Y Gastric Bypass surgery and 2 months, 1 year and 2 years after surgery.

  Participants will be followed for two years after they undergo surgery

• Change in brain reward response to food cues

  Two weeks before and two months after Roux-en-Y Gastric Bypass the brain reward response to the sight and smell of food will be assessed in a subset of 30 participants.

  Before and 2 months after surgery

Secondary Outcomes (1)

• Plasma levels of endocannabinoids and satiety hormones

  Before and 2 months after surgery

Other Outcomes (4)

• Descriptives

  Before surgery

• Appetite ratings

  During fMRI measurements, i.e., before and two months after surgery

• Olfactory performance

  At each fMRI measurement, i.e., before and two months after surgery

Study Arms (1)

RYGB

Food preference assessment in 100 patients at different timepoints, in a subset of 30 participants, also brain reward response to food cues will be assessed.

Procedure: Roux-en-Y Gastric Bypass

Interventions

Roux-en-Y Gastric Bypass PROCEDURE

RYGB

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Morbidly obese individuals (age 18-55 years) scheduled for Roux-en-Y gastric bypass surgery at Rijnstate hospital, Arnhem

You may qualify if:

• Scheduled for Roux-en-Y Gastric Bypass Surgery at Rijnstate hospital

You may not qualify if:

• Lack of appetite
• Having difficulties swallowing/eating
• Being a vegetarian
• Allergic to food product used as stimuli in the study

Sponsors & Collaborators

• Wageningen University: lead
• Rijnstate Hospital: collaborator

Study Sites (3)

Rijnstate Hospital

Arnhem, Gelderland, 6800 TA, Netherlands

Location

Gelderse Vallei Hospital

Ede, Gelderland, 6716 RP, Netherlands

Location

Wageningen University

Wageningen, Gelderland, 6700 EV, Netherlands

Location

MeSH Terms

Interventions

Gastric Bypass

Intervention Hierarchy (Ancestors)

Bariatric Surgery; Bariatrics; Obesity Management; Therapeutics; Gastroenterostomy; Anastomosis, Surgical; Surgical Procedures, Operative; Digestive System Surgical Procedures

Study Officials

• Suzanne EM de Bruijn, MSc

  Wageningen University

  PRINCIPAL INVESTIGATOR

• Harriët FA Zoon, MSc

  Wageningen University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 5, 2014
• First Posted: February 20, 2014
• Study Start: July 1, 2014
• Primary Completion: September 1, 2017
• Last Updated: May 23, 2017

Record last verified: 2017-05

Locations

NL (3)