NCT04929210

Brief Summary

The purpose of this study is to evaluate the efficacy of guselkumab treatment in participants with active psoriatic arthritis (PsA) axial disease by assessing reduction in axial symptoms and inflammation.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
411

participants targeted

Target at P75+ for phase_4

Timeline
11mo left

Started Aug 2021

Longer than P75 for phase_4

Geographic Reach
26 countries

240 active sites

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress83%
Aug 2021Apr 2027

First Submitted

Initial submission to the registry

June 11, 2021

Completed
7 days until next milestone

First Posted

Study publicly available on registry

June 18, 2021

Completed
2 months until next milestone

Study Start

First participant enrolled

August 30, 2021

Completed
4.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 4, 2026

Expected
8 months until next milestone

Study Completion

Last participant's last visit for all outcomes

April 13, 2027

Last Updated

April 13, 2026

Status Verified

April 1, 2026

Enrollment Period

4.9 years

First QC Date

June 11, 2021

Last Update Submit

April 9, 2026

Conditions

Outcome Measures

Primary Outcomes (1)

  • Change from Baseline in Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) Score at Week 24

    BASDAI is a self-assessment tool that consists of 6 questions relating to 5 major symptoms of ankylosing spondylitis: fatigue, spinal pain, joint pain, enthesitis, qualitative morning stiffness and quantitative morning stiffness. First 5 items were scored on a 10 centimeter (cm) visual analog scale (VAS) ranging from 0 equals to (=) none to 10=very severe. Quantitative morning stiffness was scored on a 10 cm VAS ranging from 0=0 hours to 10=2 or more hours. 2 scores for qualitative and quantitative morning stiffness were averaged, and total BASDAI score was average of the 5 scores of each symptom, ranging from 0 (none) to 10 (very severe). Higher scores indicate greater disease severity.

    Baseline and Week 24

Secondary Outcomes (19)

  • Change from Baseline in Ankylosing Spondylitis Disease Activity Score-C-Reactive Protein (ASDAS-CRP) at Week 24

    Baseline and Week 24

  • Change from Baseline in Disease Activity Index for Psoriatic Arthritis (DAPSA) at Week 24

    Baseline and Week 24

  • Change from Baseline in Health Assessment Questionnaire - Disability Index (HAQ-DI) Score at Week 24

    Baseline and Week 24

  • Percentage of Participants with Investigator's Global Assessment (IGA) 0/1 Response at Week 24 among Participants with >= 3% Body Surface Area (BSA) Psoriatic Involvement and an IGA Score of >=2 (Mild) at Baseline

    Week 24

  • Change from Baseline in Spondyloarthritis Research Consortium of Canada (SPARCC) Score for Magnetic Resonance Imaging (MRI) Sacroiliac (SI) Joints at Week 24

    Baseline and Week 24

  • +14 more secondary outcomes

Study Arms (3)

Group 1: Guselkumab and Placebo

EXPERIMENTAL

Participants will receive guselkumab and matching placebo subcutaneously (SC) to maintain the blind.

Drug: GuselkumabDrug: Placebo

Group 2: Guselkumab

EXPERIMENTAL

Participants will receive guselkumab SC.

Drug: Guselkumab

Group 3: Placebo followed by Guselkumab

EXPERIMENTAL

Participants will receive matching placebo and will cross over to receive guselkumab SC.

Drug: GuselkumabDrug: Placebo

Interventions

Guselkumab will be administered as subcutaneous injection.

Also known as: TREMFYA
Group 1: Guselkumab and PlaceboGroup 2: GuselkumabGroup 3: Placebo followed by Guselkumab

Matching placebo will be administered as subcutaneous injection.

Group 1: Guselkumab and PlaceboGroup 3: Placebo followed by Guselkumab

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Have a diagnosis of psoriatic arthritis (PsA) for at least 6 months prior to the first administration of study intervention and meet classification criteria for psoriatic arthritis (CASPAR) criteria at screening
  • Have active PsA as defined by: a) at least 3 swollen joints and at least 3 tender joints at screening and at baseline and b) C-reactive protein (CRP) greater than or equal to (\>=) 0.3 milligram/deciliter (mg/dL) at screening from the central laboratory, and despite previous non-biologic disease modifying antirheumatic drug (DMARD), apremilast, and/or nonsteroidal anti-inflammatory drug (NSAID) therapy
  • Have magnetic resonance imaging (MRI)-confirmed PsA axial disease (positive MRI spine and/or sacroiliac \[SI\] joints, shown by a Spondyloarthritis Research Consortium of Canada \[SPARCC\] score of \>= 3 in either the spine or the sacroiliac joints)
  • Have a Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score of at least 4, and have a spinal pain score (on a visual analog scale \[VAS\]) of at least 4
  • Have active plaque psoriasis, with at least 1 psoriatic plaque of \>= 2 centimeter (cm) diameter and/or nail changes consistent with psoriasis, or documented history of plaque psoriasis

You may not qualify if:

  • Has known allergies, hypersensitivity, or intolerance to guselkumab or its excipients
  • Has other inflammatory diseases that might confound the evaluations of benefit of guselkumab therapy, including but not limited to rheumatoid arthritis (RA), ankylosing spondylitis (AS)/non-radiographic-axial spondyloarthritis (this does not include a primary diagnosis of PsA with spondylitis), systemic lupus erythematosus, or Lyme disease
  • Has previously received any biologic treatment
  • Has ever received a Janus kinase (JAK) inhibitor including but not limited to tofacitinib, baricitinib, filgotinib, peficitinib, decernotinib, upadacitinib or any other investigational JAK inhibitor
  • Has received any systemic immunosuppressants (example, azathioprine, cyclosporine, 6 thioguanine, mercaptopurine, mycophenolate mofetil, hydroxyurea, tacrolimus) within 4 weeks of the first administration of study intervention

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (240)

Arizona Arthritis and Rheumatology Research PLLC 1

Avondale, Arizona, 85392, United States

Location

Arizona Arthritis & Rheumatology Research, PLLC

Chandler, Arizona, 85225, United States

Location

Arizona Arthritis and Rheumatology Research PLLC

Mesa, Arizona, 85210, United States

Location

Arizona Arthritis Research, PLC.

Phoenix, Arizona, 85032, United States

Location

Arizona Arthritis and Rheumatology Associates

Sun City, Arizona, 85351, United States

Location

Southern Arizona VA Healthcare System

Tucson, Arizona, 85723, United States

Location

Unity Health-White County Medical Center

Searcy, Arkansas, 72143, United States

Location

Kaiser Permanent Medical Center

Fontana, California, 92335, United States

Location

Newport Huntington Medical Group

Huntington Beach, California, 92648, United States

Location

University Of California San Diego

La Jolla, California, 92093, United States

Location

Rheumatology Center of San Diego

San Diego, California, 92128, United States

Location

Clinical Research Center of Connecticut

Danbury, Connecticut, 06810, United States

Location

Bay Pines VA Healthcare System

Bay Pines, Florida, 33744, United States

Location

Integral Rheumatology And Immunology Specialists

Plantation, Florida, 33324, United States

Location

Florida Medical Clinic, P.A.

Zephyrhills, Florida, 33542, United States

Location

Great Lakes Clinical Trials

Chicago, Illinois, 60640, United States

Location

OrthoIllinois

Rockford, Illinois, 61114, United States

Location

Willow Rheumatology and Wellness

Willowbrook, Illinois, 60527, United States

Location

Johns Hopkins Bayview Medical

Baltimore, Maryland, 21224, United States

Location

Klein And Associates M D P A

Hagerstown, Maryland, 21740, United States

Location

Clinical Research Institute of Michigan, LLC

Saint Clair Shores, Michigan, 48081, United States

Location

St. Paul Rheumatology P A

Eagan, Minnesota, 55121, United States

Location

Kansas City Physician Partners

Kansas City, Missouri, 64111, United States

Location

Clinvest

Springfield, Missouri, 65807, United States

Location

STAT Research, Inc.

Vandalia, Ohio, 45377, United States

Location

OHSU Rheumatology Clinic, Marquam Hill

Portland, Oregon, 97239, United States

Location

Amarillo Center for Clinical Research

Amarillo, Texas, 79124, United States

Location

Austin Regional Clinic

Austin, Texas, 78731, United States

Location

Precision Comprehensive Clinical Research Solutions

Colleyville, Texas, 76034, United States

Location

Adriana Pop Moody MD Clinic PA

Corpus Christi, Texas, 78404, United States

Location

AARA Clinical Research Lone Star Arthritis and Rheumatology 1

Fort Worth, Texas, 76109, United States

Location

UT Physicians Center for Autoimmunity

Houston, Texas, 77030, United States

Location

AARA Clinical Research Lone Star Arthritis and Rheumatology

Irving, Texas, 75039, United States

Location

West Texas Clinical Research

Lubbock, Texas, 79424, United States

Location

Southwest Rheumatology Research LLC

Mesquite, Texas, 75150, United States

Location

Epic Medical Research

Red Oak, Texas, 75154, United States

Location

DM Clinical Research

Tomball, Texas, 77375, United States

Location

Swedish Medical Center

Seattle, Washington, 98104, United States

Location

Cosultorios Reumatologógicos Pampa

Buenos Aires, 1428, Argentina

Location

Hospital Italiano de Buenos Aires

Buenos Aires, C1199ABB, Argentina

Location

Centro Privado de Medicina Familiar

Buenos Aires, C1417, Argentina

Location

Hospital Italiano La Plata

La Plata, B1900, Argentina

Location

MR Medicina Reumatologica

San Fernando, B1646, Argentina

Location

Centro Medico Privado de Reumatologia

San Miguel de Tucumán, T4000AXL, Argentina

Location

Emeritus Research

Camberwell, 3124, Australia

Location

Southern Clinical Research

Hobart, 7000, Australia

Location

Liverpool Hospital

Liverpool, 2170, Australia

Location

Rheumatology Research Unit

Maroochydore, 4558, Australia

Location

Skin Health Institute Inc.

Melbourne, 3053, Australia

Location

Eastern Health - Box Hill Hospital

Melbourne, 3128, Australia

Location

Exacta Medica

Pleven, 5803, Bulgaria

Location

UMHAT 'Dr. Georgi Stranski', EAD

Pleven, 5804, Bulgaria

Location

Medical Center Unimed Plovdiv

Plovdiv, 4001, Bulgaria

Location

UMHAT Kaspela

Plovdiv, 4001, Bulgaria

Location

Medical Center Artmed

Plovdiv, 4002, Bulgaria

Location

MHAT 'Lyulin' EAD

Sofia, 1336, Bulgaria

Location

University Multiprofile Hospital Sofiamed Sofia

Sofia, 1336, Bulgaria

Location

Military Medical Academy

Sofia, 1606, Bulgaria

Location

UMHAT St. Ivan Rilski

Sofia, 1612, Bulgaria

Location

DCC Convex EOOD

Sofia, 1680, Bulgaria

Location

ASIMP Rheumatology Centre St Irina EOOD

Sofia, 1750, Bulgaria

Location

Medical Centre Synexus

Sofia, 1794, Bulgaria

Location

DDC Sv. Ivan Rilski OOD

Targovishte, 7700, Bulgaria

Location

Skin Care Centre

Vancouver, British Columbia, V5Z 4E8, Canada

Location

Eastern Regional Health Authority St Clares Mercy Hospital

St. John's, Newfoundland and Labrador, A1C 5B8, Canada

Location

Toronto Western Hospital

Toronto, Ontario, M5T 2S8, Canada

Location

G R M O Groupe de recherche en maladies osseuses Inc

Québec, Quebec, G1V 3M7, Canada

Location

Revmaclinic

Brno, 61141, Czechia

Location

Revmatologie s r o

Brno, 63800, Czechia

Location

Revmacentrum MUDr Mostera s r o

Brno-Židenice, 615 00, Czechia

Location

L K N Arthrocentrum

Hlučín, 748 01, Czechia

Location

Revimex Pro s r o

Karvina Frystat, 73301, Czechia

Location

MUDr Rosypalova s r o

Ostrava, 70800, Czechia

Location

Arthrohelp S.R.O.

Pardubice, 53002, Czechia

Location

Revmatologicky ustav

Prague, 128 00, Czechia

Location

Medical Plus S R O

Uherské Hradiště, 68601, Czechia

Location

Frederiksberg Hospital

Frederiksberg, 2000, Denmark

Location

Rigshospitalet Glostrup

Glostrup Municipality, 2600, Denmark

Location

Køge Sygehus Region Sjaelland

Køge, 4600, Denmark

Location

Vejle Sygehus

Vejle, 7100, Denmark

Location

Ltd Health Center

Batumi, 6010, Georgia

Location

LTD Clinic LJ

Kutaisi, 4600, Georgia

Location

Aleksandre Aladashvili Clinic LLC

Tbilisi, 0102, Georgia

Location

Ltd American Hospital Network

Tbilisi, 0102, Georgia

Location

LTD Helsicore

Tbilisi, 0112, Georgia

Location

Ltd New Hospitals

Tbilisi, 0114, Georgia

Location

TSMU The First University Clinic

Tbilisi, 0141, Georgia

Location

JSC K Eristavi National Center of experimental and Clinical surgery

Tbilisi, 0159, Georgia

Location

Tbilisi Heart and Vascular Clinic Ltd

Tbilisi, 0159, Georgia

Location

LTD 'Aversi Clinic'

Tbilisi, 0160, Georgia

Location

LTD MediClub Georgia

Tbilisi, 0160, Georgia

Location

Clinic on Mtskheta Street

Tbilisi, 0179, Georgia

Location

LTD The First Medical Center

Tbilisi, 0180, Georgia

Location

Consilium Medulla-multiprofile clinic Ltd

Tbilisi, 0186, Georgia

Location

JSC Evex Hospitals

Tnilisi, 0159, Georgia

Location

ISA - Interdisciplinary Study Association GmbH

Berlin, 10789, Germany

Location

Hamburger Rheuma Forschungszentrum II

Hamburg, 20095, Germany

Location

Rheumazentrum Ruhrgebiet

Herne, 44649, Germany

Location

Rheumazentrum Ratingen

Ratingen, 40878, Germany

Location

Prince Of Wales Hospital

Hong Kong, Hong Kong

Location

Betegapolo Irgalmas Rend Budai Irgalmasrendi Korhaz

Budapest, 1023, Hungary

Location

Obudai Egeszsegugyi Centrum Kft

Budapest, 1036, Hungary

Location

Qualiclinic Kft

Budapest, H-1036, Hungary

Location

Bekes Varmegyei Kozponti Korhaz Pandy Kalman Tagkorhaz

Gyula, 5700, Hungary

Location

Porcika Klinika - Vasarhelyi Sarkanyfu Kft.

Hódmezővásárhely, 6800, Hungary

Location

Kistarcsai Flor Ferenc Korhaz

Kistarcsa, 2143, Hungary

Location

Fejer Varmegyei Szent Gyorgy Egyetemi Oktatokorhaz

Székesfehérvár, 8000, Hungary

Location

Vital Medical Center Orvosi es Fogaszati Kozpont

Veszprém, 8200, Hungary

Location

Bnai Zion Medical Center

Haifa, 31048, Israel

Location

Carmel Medical Center

Haifa, 34362, Israel

Location

Wolfson Medical Center

Holon, 5822012, Israel

Location

Meir Medical Center

Kfar Saba, 4428164, Israel

Location

Sheba Medical Center

Ramat Gan, 5265601, Israel

Location

A.O. Universitaria Ospedali Riuniti di Ancona

Ancona, 60126, Italy

Location

Azienda Ospedaliero-Universitaria di Cagliari

Monserrato, 09124, Italy

Location

Arcispedale Santa Maria Nuova - IRCCS

Reggio Emilia, 42123, Italy

Location

Policlinico Tor Vergata

Roma, 00133, Italy

Location

Humanitas Hospital

Rozzano (MI), 20089, Italy

Location

Azienda Ospedaliera Universitaria Integrata Verona

Verona, 37126, Italy

Location

Hospital Selayang

Batu Caves, 68100, Malaysia

Location

Hospital Pulau Pinang

George Town, 10990, Malaysia

Location

Hospital Sultan Ismail

Johor Bahru, 81100, Malaysia

Location

University Malaya Medical Centre

Kuala Lumpur, 59100, Malaysia

Location

Hospital Tuanku Jaafar

Seremban, 70300, Malaysia

Location

Cebu Doctors' University Hospital

Cebu City, 6000, Philippines

Location

Davao Doctors Hospital

Davao City, 8000, Philippines

Location

Lipa Medix Medical Hospital

Lipa, 4217, Philippines

Location

ManilaMed Medical Center Manila

Manila, 1000, Philippines

Location

Philippine General Hospital

Manila, 1000, Philippines

Location

St. Luke's Medical Center

Quezon City, 1112, Philippines

Location

Ilocos Training and Regional Medical Center

San Fernando City, 2500, Philippines

Location

ClinicMed Daniluk Nowak Spolka Komandytowa

Bialystok, 15 879, Poland

Location

Szpital Uniwersytecki nr 2 im dr Jana Biziela

Bydgoszcz, 85 168, Poland

Location

Nzoz Bif Med

Bytom, 41 902, Poland

Location

Ambulatorium sp. z o.o.

Elblag, 82-300, Poland

Location

Centrum Kliniczno Badawcze

Elblag, 82-300, Poland

Location

Malopolskie Badania Kliniczne Sp z o o

Krakow, 30-002, Poland

Location

Centrum Medyczne Promed

Krakow, 31-513, Poland

Location

Dermed Centrum Medyczne Sp z o o

Lodz, 90-265, Poland

Location

Centrum Terapii Wspolczesnej J M Jasnorzewska Spolka Komandytowo Akcyjna

Lodz, 90-338, Poland

Location

Centrum Medyczne AMED oddzial w Lodzi

Lodz, 91 363, Poland

Location

Velocity Lublin

Lublin, 20 362, Poland

Location

Reumed Zespol Poradni Specjalistycznych Filia nr 1

Lublin, 20 607, Poland

Location

Pro Life Medica Sp. z o.o.

Lublin, 20-412, Poland

Location

NZOZ Lecznica MAK MED S C

Nadarzyn, 05-830, Poland

Location

Twoja Przychodnia - Centrum Medyczne Nowa Sol

Nowa Sól, 67-100, Poland

Location

Twoja Przychodnia PCM

Poznan, 60 324, Poland

Location

Reumedika s c Wieslawa Porawska Lukasz Porawski

Poznan, 60-446, Poland

Location

Lubelskie Centrum Diagnostyczne

Świdnik, 21 040, Poland

Location

MICS Centrum Medyczne Torun

Torun, 87-100, Poland

Location

MICS Centrum Medyczne Warszawa

Warsaw, 00-874, Poland

Location

Rheuma Medicus Sp z o o

Warsaw, 02 118, Poland

Location

Narodowy Instytut Geriatrii Reumatologii i Rehabilitacji im prof dr hab med Eleonory Reicher

Warsaw, 02 637, Poland

Location

Centrum Medyczne Reuma Park

Warsaw, 02-665, Poland

Location

ETG Warszawa

Warsaw, 02-793, Poland

Location

Centrum Medyczne AMED Targowek

Warsaw, 03 291, Poland

Location

WroMedica I Bielicka A Strzalkowska s c

Wroclaw, 51 685, Poland

Location

Uls Braga - Hosp. Braga

Braga, 4710-243, Portugal

Location

Ulsg - Hosp. Sousa Martins

Guarda, 6300-749, Portugal

Location

Ipr Inst Port de Reumatologia

Lisbon, 1050 034, Portugal

Location

Uls Lisboa Ocidental - Hosp. Egas Moniz

Lisbon, 1349-019, Portugal

Location

Hosp. Cuf Tejo

Lisbon, 1350-352, Portugal

Location

Uls Santa Maria - Hosp. Santa Maria

Lisbon, 1649-035, Portugal

Location

Ulsam - Hosp. Conde de Bertiandos

Ponte de Lima, 4990-041, Portugal

Location

Uls Sao Joao - Hosp. Sao Joao

Porto, 4200 319, Portugal

Location

Altay Medical State University

Barnaul, 656038, Russia

Location

Chelyabinck Regional Clinical Hospital

Chelyabinsk, 454076, Russia

Location

Chelyabinsk Regional Clinical Dermatovenerological Dispensary

Chelyabinsk, 454092, Russia

Location

Regional Clinical Diagnostic Center of Udmurtia Region

Izhevsk, 426009, Russia

Location

LLL Medical Center Revma-Med

Kemerovo, 650070, Russia

Location

LLC Family Outpatient Clinic # 4

Korolyov, 141060, Russia

Location

Regional SBI of PH Krasnoyarsk Regional Clinical hospital #20 named after I.S. Berzon

Krasnoyarsk, 660123, Russia

Location

Clinical-Diagnostic Center Euromedservice, JSC

Moscow, 115419, Russia

Location

FGBU Research Institute of Rheumatology named V.A.Nasonova

Moscow, 115522, Russia

Location

GBUZ of Moscow Region 'Moscow Region SRI n.a. Vladimirskyi'

Moscow, 129110, Russia

Location

Llc Ultramed

Omsk, 644024, Russia

Location

GBOU VPO Orenburg State Medical University

Orenburg, 460000, Russia

Location

GBUZ Perm Regional Clinical Hospital

Perm, 614990, Russia

Location

Republican Hospital n.a.V.A.Baranov

Petrozavodsk, 185019, Russia

Location

Rostov Regional Clinical Dermatovenerological Dispensary

Rostov-on-Don, 344007, Russia

Location

St. Petersburg GBUZ Clinical Reumatological Hospital 25

Saint Petersburg, 190068, Russia

Location

X7 Clinical Research Company Limited

Saint Petersburg, 194156, Russia

Location

GBUZ of Samara Region 'Tolyatti City Clinical Hospital 5'

Tolyatti, 445846, Russia

Location

Republican Clinical Hospital - G.G. Kuvatov

Ufa, 450005, Russia

Location

Clinical Hospital #3

Yaroslavl, 150007, Russia

Location

Sverdlovsk Regional Clinical Hospital N. 1

Yekaterinburg, 620102, Russia

Location

Reumatologicka Ambulancia 1

Martin, 036 01, Slovakia

Location

Reumatologicka ambulancia

Nové Mesto nad Váhom, 91501, Slovakia

Location

Reumatologická ambulancia Thermium s.r.o.

Piešťany, 921 01, Slovakia

Location

REUMAMED POPRAD, s.r.o.

Poprad, 05801, Slovakia

Location

Reumex s.r.o

Rimavská Sobota, Slovakia

Location

Hosp Univ A Coruna

A Coruña, 15006, Spain

Location

Hosp. Univ. de Cruces

Barakaldo, 48902, Spain

Location

Hosp Clinic de Barcelona

Barcelona, 08036, Spain

Location

Hosp. Univ. de Basurto

Bilbao, 48013, Spain

Location

Hosp Reina Sofia

Córdoba, 14004, Spain

Location

Hosp. Clinico San Carlos

Madrid, 28040, Spain

Location

Hosp Regional Univ de Malaga

Málaga, 29009, Spain

Location

Corporacio Sanitari Parc Tauli

Sabadell, 8208, Spain

Location

Clinica Gaias

Santiago de Compostela, 15702, Spain

Location

Hosp. Virgen Macarena

Seville, 41009, Spain

Location

Hosp. Quiron Sagrado Corazon

Seville, 41013, Spain

Location

Hosp. Univ. I Politecni La Fe

Valencia, 46026, Spain

Location

Karolinska Universitetssjukhuset

Solna, 171 76, Sweden

Location

Akademiska Sjukhuset

Uppsala, 753 09, Sweden

Location

National Cheng Kung University Hospital

Tainan, 704, Taiwan

Location

National Taiwan University Hospital

Taoyuan District, 30059, Taiwan

Location

Linkou Chang Gung Memorial Hospital

Taoyuan District, 33305, Taiwan

Location

Phramongkutklao Hospital and Medical College

Bangkok, 10400, Thailand

Location

Ramathibodi Hospital Mahidol University

Bangkok, 10400, Thailand

Location

Chiang Mai University

Chiang Mai, 50200, Thailand

Location

Adana City Hospital

Adana, 01370, Turkey (Türkiye)

Location

Gulhane Training and Research Hospital

Ankara, 06010, Turkey (Türkiye)

Location

Ankara Bilkent City Hospital

Ankara, 06800, Turkey (Türkiye)

Location

Hacettepe University Medical Faculty

Ankara, 6100, Turkey (Türkiye)

Location

Akdeniz University Medical Faculty

Antalya, 7059, Turkey (Türkiye)

Location

Uludag University Medical Faculty

Bursa, 16059, Turkey (Türkiye)

Location

Istanbul University Cerrahpasa Medical Faculty

Istanbul, 34098, Turkey (Türkiye)

Location

Marmara University Medical Faculty

Istanbul, 34899, Turkey (Türkiye)

Location

Necmettin Erbakan University Meram Medical Faculty

Konya, 42080, Turkey (Türkiye)

Location

Communal Noncommercial Enterprise Cherkasy Regional Hospital of Cherkasy Regional Council

Cherkasy, 18009, Ukraine

Location

Municipal non-commercial enterprise of Kharkiv Regional Council Regional Clinical Hospital

Kharkiv, 61204, Ukraine

Location

Khmelnitckiy regional hospital

Khmelnytsky, 29000, Ukraine

Location

City Clinical Hospital No. 2

Kryvyi Rih, 50056, Ukraine

Location

Medical Center of 'Institute of Rheumatology', LLC

Kyiv, 02081, Ukraine

Location

Kyiv Railway Clinical Hospital #2 Of Branch 'Health Center' Of The Company 'Ukrainian Railway'

Kyiv, 03049, Ukraine

Location

SI National Scientific Center Institute of Cardiology of M.D. Strazhesko of NAMS of Ukraine

Kyiv, 03680, Ukraine

Location

Volyn Regional Clinical Hospital

Lutsk, 43005, Ukraine

Location

Municipal Non-profit Enterprise 'Odesa Regional Clinical Hospital' Odesa Regional Council

Odesa, 65025, Ukraine

Location

ME Poltava Regional Clinical Hospital named after M.V. Sklifosovsky of Poltava Regional Consuil

Poltava, 36011, Ukraine

Location

Municipal institution of Tepnopil Regional Council 'Ternopil University Hospital'

Ternopil, 46002, Ukraine

Location

Health Clinic Limited Liability Company

Vinnytsia, 21009, Ukraine

Location

Medical Center LLC 'Modern Clinic'

Zaporizhzhya, 69600, Ukraine

Location

Royal Free London NHS Foundation Trust

Barnet, EN5 3DJ, United Kingdom

Location

St. Lukes Hospital

Bradford, BD5 0NA, United Kingdom

Location

University Hospital Coventry & Warwickshire NHS Trust

Coventry, CV2 2DX, United Kingdom

Location

Chapel Allerton Hospital

Leeds, LS7 4SA, United Kingdom

Location

Central Manchester University Hospitals NHS Foundation Trust

Manchester, M13 9WL, United Kingdom

Location

North Tyneside General Hospital

Newcastle, NE29 8NH, United Kingdom

Location

Haywood Hospital

Stoke-on-Trent, ST6 7AG, United Kingdom

Location

Related Publications (1)

  • Gladman DD, Mease PJ, Bird P, Soriano ER, Chakravarty SD, Shawi M, Xu S, Quinn ST, Gong C, Leibowitz E, Poddubnyy D, Tam LS, Helliwell PS, Kavanaugh A, Deodhar A, Ostergaard M, Baraliakos X. Efficacy and safety of guselkumab in biologic-naive patients with active axial psoriatic arthritis: study protocol for STAR, a phase 4, randomized, double-blinded, placebo-controlled trial. Trials. 2022 Sep 5;23(1):743. doi: 10.1186/s13063-022-06589-y.

MeSH Terms

Conditions

Arthritis, Psoriatic

Interventions

guselkumab

Condition Hierarchy (Ancestors)

SpondylarthropathiesSpondylarthritisSpondylitisSpinal DiseasesBone DiseasesMusculoskeletal DiseasesArthritisJoint DiseasesPsoriasisSkin Diseases, PapulosquamousSkin DiseasesSkin and Connective Tissue Diseases

Study Officials

  • Janssen Research & Development, LLC Clinical Trial

    Janssen Research & Development, LLC

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
phase 4
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 11, 2021

First Posted

June 18, 2021

Study Start

August 30, 2021

Primary Completion (Estimated)

August 4, 2026

Study Completion (Estimated)

April 13, 2027

Last Updated

April 13, 2026

Record last verified: 2026-04

Data Sharing

IPD Sharing
Will share

The data sharing policy of the Janssen Pharmaceutical Companies of Johnson \& Johnson is available at www.janssen.com/clinical-trials/transparency. As noted on this site, requests for access to the study data can be submitted through Yale Open Data Access (YODA) Project site at yoda.yale.edu

More information

Locations