Resistance Training Effects on Gut Microbiome and Cardiometabolic Outcomes

NCT04906525 | Completed

• 1 other identifier: 2054484
• Study Type: interventional
• Target: 34
• Locations: 1 country
• Sites: 1

Brief Summary

The overall objective of this study is to investigate the effects of resistance training on the gut microbiome and cardiometabolic outcomes in adults with overweight and obesity.

Conditions

Exercise Intervention

Keywords

Gut Microbiome; Resistance Training; Physical Activity

Outcome Measures

Primary Outcomes (2)

• Change in stool microbiome diversity

  16s rRNA sequencing

  Change over 6 weeks

• Change in stool microbiome composition

  16s rRNA sequencing

  Change over 6 weeks

Secondary Outcomes (13)

• Change in blood pressure

  change over 6 weeks

• Fat mass

  Change over 6 weeks

• Fat free mass

  Change over 6 weeks

• Change in fasting glucose

  change over 6 weeks

• Change in glucose regulation

  change over 6 weeks

Other Outcomes (1)

• Food environment perceptions

  baseline and at the end of 6 week intervention

Study Arms (2)

Conventional physical activity guidelines

OTHER

Participants are given recommendations on physical activity guidelines

Other: Conventional physical activity guidelines

Resistance training

EXPERIMENTAL

Participants will undergo 6 weeks of supervised resistance training

Behavioral: Resistance training

Interventions

Resistance training BEHAVIORAL

Participants will undergo 6 weeks of supervised resistance training

Resistance training

Conventional physical activity guidelines OTHER

Participants are given recommendations on physical activity guidelines

Conventional physical activity guidelines

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age 18-35 years
• BMI: 25-45 kg/m2
• Sedentary lifestyle
• Consistent diet patterns
• Weight-stable (\<4 kg change over the last 3 mo)
• Willingness to adhere to resistance training protocol and not change diet
• Non-smoker \>1 year or more

You may not qualify if:

• Disabilities preventing adherence to resistance training protocol
• Recent start of medications that affect metabolism or appetite
• Antibiotics
• Diabetes
• Drug therapy for coronary artery disease, peripheral artery disease, congestive heart failure, or dyslipidemia
• Uncontrolled hypertension and blood pressure ≥ 180/110
• Gastrointestinal disease and/or bariatric surgery
• Smoking
• Illicit drug use
• Pregnant or lactating individuals

Sponsors & Collaborators

• University of Missouri-Columbia: lead

Study Sites (1)

University of Missouri

Columbia, Missouri, 65211, United States

Location

MeSH Terms

Conditions

Motor Activity

Interventions

Resistance Training

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Jaapna Dhillon, PhD

  University of Missouri-Columbia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: May 5, 2021
• First Posted: May 28, 2021
• Study Start: May 19, 2021
• Primary Completion: September 30, 2022
• Study Completion: September 30, 2022
• Last Updated: March 13, 2023

Record last verified: 2023-03

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, ICF
• Time Frame: Immediately following publication. No end date.
• Access Criteria: Data will be deposited in online data repositories.

Locations

US (1)