Social Relationships and Accelerated Aging in Hematopoietic Cell Transplant Survivors

NCT04892823 | Recruiting

• 3 other identifiers: 43000NCI-2021-02616K01AG065485
• Study Type: observational
• Target: 110
• Locations: 1 country
• Sites: 1

Brief Summary

This project aims to elucidate the important protective elements of social relationships and identify concrete, modifiable behavioral factors that contribute to biological and phenotypic aging in hematopoietic cell transplantation (HCT) survivors and can be used to develop biologically informed interventions to improve quality of life and prolong the healthspan of individuals with accelerated aging.

Conditions

Hematopoietic and Lymphoid Cell Neoplasm

Outcome Measures

Primary Outcomes (1)

• The number of participants with gene expression of cellular senescence marker p16.

  This will be measured by mRNA/gene expression.

  Day 100 and 1 year post-transplant

Study Arms (1)

Supportive care (EAR, questionnaires, biospecimen collection)

Participants will complete comprehensive assessments of social processes at 100 days and 1 year after HCT that combine reports of social support, strain, and isolation with a naturalistic observation tool, the Electronically Activated Recorder (EAR), which captures ambient sound bites to assess social interactions in survivors' daily lives. At each time point, participants will also provide reports of symptoms to characterize phenotypic aging, including cognitive, physical, and functional complaints, and blood samples to assess biological aging, including cellular senescence, DNA damage, SASP, and cellular stress using genome wide RNA sequencing. Relevant clinical information that could influence biological aging will also be collected from patients' medical records to consider as covariates.

Procedure: Biospecimen Collection; Other: Electronic Health Record Review; Other: Questionnaire Administration

Interventions

Biospecimen Collection PROCEDURE

Undergo collection of blood sample

Supportive care (EAR, questionnaires, biospecimen collection)

Electronic Health Record Review OTHER

Review of medical records

Supportive care (EAR, questionnaires, biospecimen collection)

Questionnaire Administration OTHER

Complete questionnaires

Supportive care (EAR, questionnaires, biospecimen collection)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients undergoing HCT for hematologic cancers.

You may qualify if:

• Aged 18 years and older who are competent to give their informed consent.
• Ability to read, speak, and understand English.
• Received a hematopoietic cell transplant within the previous 100 days.

You may not qualify if:

• Less then Aged 18 years and older who are competent to give their informed consent.
• Cannot read, speak, and understand English.
• Has not received a hematopoietic cell transplant within the previous 100 days.

Sponsors & Collaborators

• Medical College of Wisconsin: lead
• National Institute on Aging (NIA): collaborator

Study Sites (1)

Froedtert Hospital and the Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Blood

MeSH Terms

Conditions

Hematologic Neoplasms

Condition Hierarchy (Ancestors)

Neoplasms by Site; Neoplasms; Hematologic Diseases; Hemic and Lymphatic Diseases

Study Officials

• Kelly Rentscher, PhD

  Medical College of Wisconsin

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Medical College of Wisconsin Cancer Center Clinical Trials Office

CONTACT

866-680-0505; cccto@mcw.edu

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: May 10, 2021
• First Posted: May 19, 2021
• Study Start: May 18, 2021
• Primary Completion: May 31, 2026
• Study Completion: May 31, 2026
• Last Updated: July 16, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)