Key Insights

Highlights

Success Rate

78% trial completion

Published Results

51 trials with published results (26%)

Research Maturity

62 completed trials (32% of total)

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 37/100

Termination Rate

9.3%

18 terminated out of 194 trials

Success Rate

77.5%

-9.0% vs benchmark

Late-Stage Pipeline

8%

16 trials in Phase 3/4

Results Transparency

82%

51 of 62 completed with results

Key Signals

51 with results78% success18 terminated

Data Visualizations

Phase Distribution

145Total
Not Applicable (39)
Early P 1 (5)
P 1 (34)
P 2 (51)
P 3 (13)
P 4 (3)

Trial Status

Completed62
Active Not Recruiting60
Recruiting34
Terminated18
Withdrawn17
Suspended2

Trial Success Rate

77.5%

Benchmark: 86.5%

Based on 62 completed trials

Clinical Trials (194)

Showing 20 of 20 trials
NCT04439110Phase 2Active Not Recruiting

Testing Ado-Trastuzumab Emtansine as a Potential Targeted Treatment in Cancers With HER2 Genetic Changes (MATCH-Subprotocol Q)

NCT04439344Phase 2Active Not Recruiting

Testing Binimetinib as a Potential Targeted Treatment in Cancers With NRAS Genetic Changes (MATCH-Subprotocol Z1A)

NCT04439331Phase 2Active Not Recruiting

Testing VS-6063 (Defactinib) as a Potential Targeted Treatment in Cancers With NF2 Genetic Changes (MATCH-Subprotocol U)

NCT04439266Phase 2Active Not Recruiting

Testing Crizotinib as a Potential Targeted Treatment in Cancers With ALK Genetic Changes (MATCH-Subprotocol F)

NCT04439279Phase 2Active Not Recruiting

Testing Trametinib as a Potential Targeted Treatment in Cancers With BRAF Genetic Changes (MATCH-Subprotocol R)

NCT04439123Phase 2Active Not Recruiting

Testing AZD5363 as a Potential Targeted Treatment in Cancers With AKT Genetic Changes (MATCH-Subprotocol Y)

NCT04439175Phase 2Active Not Recruiting

Testing GDC-0032 (Taselisib) as a Potential Targeted Treatment in Cancers With PIK3CA Genetic Changes (MATCH-Subprotocol I)

NCT04745910Phase 4CompletedPrimary

Pegloticase for the Reduction of Uric Acid in Patients With Tumor Lysis Syndrome

NCT05711667Phase 3RecruitingPrimary

A Study of the Drug Letermovir as Prevention of Cytomegalovirus Infection After Stem Cell Transplant in Pediatric Patients

NCT04744116Early Phase 1RecruitingPrimary

Addition of Cord Blood Tissue-Derived Mesenchymal Stromal Cells to Ruxolitinib for the Treatment of Steroid-Refractory Acute Graft Versus Host Disease

NCT04678427Not ApplicableRecruitingPrimary

Exercise Program (TEAM Me) for the Improvement of Movement and Mobility in Pediatric and Adolescent and Young Adult Patients With Cancer Undergoing a Blood Stem Cell Transplant

NCT05055011Active Not RecruitingPrimary

Parental Attitudes and Beliefs Regarding Risks Associated With Opioid Use in Children With Cancer

NCT03670966Phase 1Recruiting

211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic Syndrome

NCT02465060Phase 2Active Not Recruiting

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

NCT04439227Phase 2Active Not Recruiting

Testing AZD1775 as a Potential Targeted Treatment in Cancers With BRCA Genetic Changes (MATCH-Subprotocol Z1I)

NCT01231412Phase 3Completed

Graft-Versus-Host Disease Prophylaxis in Treating Patients With Hematologic Malignancies Undergoing Unrelated Donor Peripheral Blood Stem Cell Transplant

NCT02993146Phase 1Active Not RecruitingPrimary

Ropidoxuridine and Whole Brain Radiation Therapy in Treating Patients With Brain Metastases

NCT04439253Phase 2Active Not Recruiting

Testing Crizotinib as a Potential Targeted Treatment in Cancers With ROS1 Genetic Changes (MATCH-Subprotocol G)

NCT04439136Phase 2Active Not Recruiting

Testing Afatinib as a Potential Targeted Treatment in Cancers With HER2 Genetic Changes (MATCH-Subprotocol B)

NCT04650178Active Not Recruiting

Well-being in Cancer Patients With Neuropathy During COVID-19 Who Participated in Prior Clinical Trials

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