Rhythmic Interlimb Coordination in Children with Developmental Coordination Disorder

NCT04891562 | Completed

• 1 other identifier: RIC-CHILD-001
• Study Type: interventional
• Target: 52
• Locations: 1 country
• Sites: 1

Brief Summary

This study is a case-controlled observational study, involving children with Developmental Coordination Disorder (DCD) and typically developing children with an age from 8 up to 12 years old. The study aims to investigate interlimb coordination of the lower limbs and sensorimotor synchronization ability in children with DCD compared to age-matched typically developing children during gait and fundamental lower limb coordination task to 2 metronomes with different temporal structures. The study consists of a maximum of 4 sessions (2 descriptive sessions, 2 experimental sessions), each lasting around 60 minutes. Depending on the preferences of the child and parents, the sessions can be combined in 2 sessions of 2 hours. During the first descriptive session, the participant will perform the m-ABC2 test to assess gross and fine motor function. The MBEMA-s will be used to examine rhythm perception ability. During the second descriptive session, children will perform the Kids BESTest to examine postural control, and two cognitive tests (digit span, go-no/go test) to assess executive functioning. During the third visit (experimental session), interlimb coordination and synchronization will be investigated during three tasks with different dynamic balance demands (seated, walking and running) in three conditions: in silence, to beats in isochronous metronome (discrete structure), to beats in non-isochronous metronomes (sinusoidal structure). In the last experimental session, the tempi of the auditory metronomes will be set at higher and lower tempi than the preferred comfortable tempo of the child.

Conditions

Developmental Coordination Disorder

Keywords

Developmental Coordination Disorder; Interlimb coordination; Gait; Sensorimotor synchronization; Metronomes

Outcome Measures

Primary Outcomes (6)

• Phase coordination index (PCI)

  PCI is a measurement of consistency and accuracy in generating a series of anti-phase left - right stepping phases. Detailed information is described in Plotnik et al. (2007). Shortly, phase represent the relative timing of contralateral heel strikes, determining the phase, and normalize the step time with respect to the stride time (Plotnik, Giladi, \& Hausdorff, 2007). Ideal interlimb coordination for each step is 180°. The consistency of the phase generation is represented by the Coefficient of variation of the series of the relative timing of the stepping of one leg with respect to the gait cycle.A lower PCI%, closer to zero, indicates a better antiphase interlimb coordination pattern.

  week 2

• Phase coordination index (PCI)

  PCI is a measurement of consistency and accuracy in generating a series of anti-phase left - right stepping phases. Detailed information is described in Plotnik et al. (2007). Shortly, phase represent the relative timing of contralateral heel strikes, determining the phase, and normalize the step time with respect to the stride time (Plotnik, Giladi, \& Hausdorff, 2007). Ideal interlimb coordination for each step is 180°. The consistency of the phase generation is represented by the Coefficient of variation of the series of the relative timing of the stepping of one leg with respect to the gait cycle.A lower PCI%, closer to zero, indicates a better antiphase interlimb coordination pattern.

  week 3

• Auditory motor coupling - Resultant Vector Length to quantify synchronization consistency

  Synchronization consistency of steps to the beats during walking and running; and of the knee flexion-extension movement to the beats during the seated task Resultant Vector Length to quantify synchronization consistency. If the distribution of the relative phase angles over time is consistent, it results in a high resultant vector length (maximum value 1). If the synchronization is not consistent, the resultant vector length will be low (minimum value 0)

  week 2

• Auditory motor coupling - Resultant Vector Length to quantify synchronization consistency

  Synchronization consistency of steps to the beats during walking and running; and of the knee flexion-extension movement to the beats during the seated task Resultant Vector Length to quantify synchronization consistency. If the distribution of the relative phase angles over time is consistent, it results in a high resultant vector length (maximum value 1). If the synchronization is not consistent, the resultant vector length will be low (minimum value 0)

  week 3

• Auditory motor coupling - Relative phase angle

  Synchronization accuracy of steps to the beats during walking and running; and of the knee flexion-extension movement to the beats during the seated task. Relative phase angle, asynchrony in time to quantify synchronization accuracy (in degrees and in milliseconds respectively)

  week 2

• Auditory motor coupling - Relative phase angle

  Synchronization accuracy of steps to the beats during walking and running; and of the knee flexion-extension movement to the beats during the seated task. Relative phase angle, asynchrony in time to quantify synchronization accuracy (in degrees and in milliseconds respectively)

  week 3

Secondary Outcomes (19)

• velocity (m/s)

  week 2

• velocity (m/s)

  week 3

• step width (cm)

  week 2

• step width (cm)

  week 3

• stride length (cm)

  week 2

Study Arms (2)

pDCD (hildren with (probably) Developmental Coordination Disorder)

EXPERIMENTAL

children with (probably) Developmental Coordination Disorder (pDCD)

Other: interlimb coordination of the lower limbs and synchronization

TDC (Typically Developing Children)

ACTIVE COMPARATOR

Typically Developing Children

Other: interlimb coordination of the lower limbs and synchronization

Interventions

interlimb coordination of the lower limbs and synchronization OTHER

4 sessions (2 descriptive sessions, 2 experimental sessions), each lasting around 60 minutes. The m-ABC2 test, The MBEMA-s, Kids BESTest, interlimb coordination and synchronization investigation (visit 3 and 4)

TDC (Typically Developing Children); pDCD (hildren with (probably) Developmental Coordination Disorder)

Eligibility Criteria

• Age: 8 Years - 12 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• are aged between 8-12 years
• have no medical conditions that could impede their motor abilities.
• Children with a diagnosis of DCD, consistent with the DSM-V (Blank et al., 2019), or total percentile score \<P16 on the movement assessment battery for children edition 2 (m-ABC-2), will be included in the group of (probably) DCD.

You may not qualify if:

• have other neurological, orthopaedical, cardiorespiratory or intellectual impairment that could affect their motor abilities (verified using a health questionnaire)

Sponsors & Collaborators

• Hasselt University: lead

Study Sites (1)

Hasselt University

Hasselt, 3500, Belgium

Location

MeSH Terms

Conditions

Motor Skills Disorders

Condition Hierarchy (Ancestors)

Neurodevelopmental Disorders; Mental Disorders

Study Officials

• Eugene Rameckers, prof. dr.

  Hasselt University

  PRINCIPAL INVESTIGATOR

• Mieke Goetschalckx, drs.

  Hasselt University

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: May 13, 2021
• First Posted: May 18, 2021
• Study Start: January 25, 2021
• Primary Completion: January 18, 2023
• Study Completion: January 18, 2023
• Last Updated: December 11, 2024

Record last verified: 2024-12

Data Sharing

• IPD Sharing: Will not share

Locations

BE (1)