NCT04887571|CompletedDMC
the PrEsentation, Rationale and Impact of reperFUSION for Acute Coronary Syndromes in Cape Town and the Garden Route Health District - the PERFUSION Registry
PERFUSION
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PERFUSION
Sponsor study identifier
observational
870
1 country
4
Study Start
February 1, 2021
Actual (reported)Primary Completion
May 31, 2022
Actual (reported)Study Completion
May 31, 2022
Actual (reported)The global burden and threat of non-communicable diseases (NCDs) have become a major health challenge that undermines social and economic development throughout the world. Cardiovascular disease including acute coronary syndromes (ACS) currently accounts for 17.9 million deaths a year. Low and middle-income countries such as those in sub-Saharan Africa (SSA) have undergone a rapid epidemiological transition over the last few decades and now have a burden of disease increasingly dominated by NCDs. The global burden of disease report for 2017 revealed a 71.4% increase in cardiovascular disease in SSA, predicting a large increase in mortality. Unfortunately, reliable population-level data regarding the incidence, prevalence and demographics of ACS in SSA are limited. The investigators propose to set up and conduct a multi-centre, prospective, observational registry to describe the demographics, clinical characteristics, presentation, management and outcomes of patients admitted with ACS in Cape Town and the Garden Route Health District, Western Cape Province, South Africa. The registry is designed to shed insight on the current burden and impact of atherosclerotic cardiovascular disease in the Western Cape.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
May 31, 2022
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
February 1, 2021
Actual (reported)May 5, 2021
Actual (reported)May 14, 2021
Actual (reported)May 31, 2022
Actual (reported)May 31, 2022
Actual (reported)1-year combined primary endpoint
all-cause death, cardiac death, re-hospitalisation myocardial infarction, cerebrovascular accident
1 year
cardiac adverse events
1-year
1 month combined end point
1-month
6 month combined end point
All consecutive adult patients in the Cape Metropole and the Garden Route Health District with an acute coronary syndrome will be recruited into the PERFUSION registry across the study duration.
All consecutive adult patients in the Cape Metropole and the Garden Route Health District with an Acute coronary syndrome (STEMI, NSTEMI, Unstable Angina) will be recruited into the PERFUSION Registry.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
The study is designed to include adult patients from the Cape Metropole and the Garden Route Health District who present with acute coronary syndromes (STEMI, NSTEMI, or Unstable Angina).
Groote Schuur Hospital
Cape Town, Western Cape, 7295, South Africa
Victoria Hospital
Cape Town, Western Cape, 7800, South Africa
New Somerset Hospital
Cape Town, Western Cape, 8001, South Africa
George Hospital
George, Western Cape, 6529, South Africa
Mpiko Ntsekhe, PhD
Groote Schuur Hospital
870 participants (actual enrollment reported by the registry).
First Submitted
May 5, 2021
First Posted
May 14, 2021
Study Start
February 1, 2021
Actual (reported)6-month
Compliance profile
1-year
Refusion time
1-year
Contact the study team to confirm eligibility.
Primary Completion
May 31, 2022
Actual (reported)Study Completion
May 31, 2022
Actual (reported)Last Updated
June 26, 2023
Record last verified: 2023-06
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
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