Topical Agents Containing Magnesium Sulfate & Wound Healing in the Rat Model
The Effect of Topical Agents in Cream Formations Containing Magnesium Sulfate on Wound Healing in the Rat Model
1 other identifier
interventional
30
1 country
1
Brief Summary
An experimental study examining wound healing in 5 different groups on 30 rats.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for early_phase_1
Started Mar 2021
Shorter than P25 for early_phase_1
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 22, 2021
CompletedFirst Submitted
Initial submission to the registry
April 13, 2021
CompletedFirst Posted
Study publicly available on registry
May 14, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2021
CompletedMay 14, 2021
April 1, 2021
2 months
April 13, 2021
May 10, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
7th day evaluation
Histopathological evaluation of wound healing comparing with the rate of vascular endothelial growth factor (VEGF), transforming growth factor (TGF-beta) and hydroxyproline at immunohistochemical staining with biopsy on the 7th day.
7th day
Secondary Outcomes (1)
15th day evaluation
15th day
Study Arms (5)
Group placebo
PLACEBO COMPARATORIsotonic solution will be administered daily to 6 female rats.
Group sham
SHAM COMPARATORBase cream to be applied twice a day to 6 female rats.
Group %1 mgso4
EXPERIMENTALCream containing 1% MgSO4 will be applied twice a day to 6 female rats.
Group %10 MgSO4
EXPERIMENTALCream containing 10% MgSO4 will be applied twice a day to 6 female rats.
Group positive control
ACTIVE COMPARATORCream containing centella asiatica will be applied twice a day to 6 female rats.
Interventions
vaseline, beeswax,polyglyceryl-3 diisostearate, sorbitan caprylate, propandiol,benzoic acid, glycerin, water
A cream containing 10 % MgSO4.vaseline, beeswaxpolyglyceryl-3 diisostearate, sorbitan caprylate, propandiol,benzoic acid, glycerin, water
A cream containing 10 % MgSO4.vaseline, beeswax,polyglyceryl-3 diisostearate, sorbitan caprylate, propandiol,benzoic acid, glycerin, water
Eligibility Criteria
You may qualify if:
- healthy rats between ages of 8- 12 weeks
You may not qualify if:
- weight loss of more than 15% of body weight
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Başakşehir Çam & Sakura City Hospitallead
- Istanbul Kent Universitycollaborator
Study Sites (1)
Başakşehir Çam Ve Sakura Hospital
Istanbul, Turkey (Türkiye)
MeSH Terms
Interventions
Study Design
- Study Type
- interventional
- Phase
- early phase 1
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- CARE PROVIDER
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER GOV
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
April 13, 2021
First Posted
May 14, 2021
Study Start
March 22, 2021
Primary Completion
June 1, 2021
Study Completion
July 1, 2021
Last Updated
May 14, 2021
Record last verified: 2021-04