Somatotopy in Parkinson's Disease

NCT04876404 | Completed

• 1 other identifier: H19-03166
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to assess changes in connections within the brain in Parkinson's disease (PD). We will invite up to 10 people with PD to participate in this study and complete several brain scans using PET (Positron Emission Tomography) and fMRI (functional Magnetic Resonance Imaging) on the Hybrid PET/MRI scanner. We will also invite 10 participants without PD to complete the same scans for comparison. "Somatotopy" refers to how areas of the brain are organized according to the body part they affect. The striatum is the brain region that coordinates complex thinking and movement. Plasticity refers to changes in connections within the brain, which can happen to make up for changes that are related to PD. In this study we will use PET and fMRI imaging together to investigate changes in the striatum in people affected by Parkinson's disease. The hybrid PET/MR scanner allows us to perform simultaneous PET and MRI measurements to investigate this.

Conditions

Parkinson Disease

Outcome Measures

Primary Outcomes (2)

• Striatal Dopamine Release

  \[11C\]raclopride PET

  Baseline

• Striatal Activation

  BOLD fMRI

  Baseline

Study Arms (2)

Parkinson's Disease

Individuals with early stage Parkinson's Disease (diagnosed within the last 5 years)

Diagnostic Test: PET/MR Imaging

Healthy Controls

Healthy control individuals with no neurological or mood disorders.

Diagnostic Test: PET/MR Imaging

Interventions

PET/MR Imaging DIAGNOSTIC_TEST

The hybrid PET/MR scanner can provide information on brain activity during various motor and cognitive tasks.

Also known as: Positron Emission Tomography and Magnetic Resonance Imaging

Healthy Controls; Parkinson's Disease

Eligibility Criteria

• Age: 50 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

People with Parkinson's Disease and those without.

You may qualify if:

• i. Recently diagnosed with early stage Parkinson's Disease (within 5 years of diagnosis) ii. Between the ages of 50 to 85 iii. Written informed consent obtained from subject and ability for subject to comply with the requirements of the study
• Healthy Control Individuals
• i. Healthy male between the ages of 50 and 85 ii. Healthy female between the ages of 50 and 85 iii. Written informed consent obtained from subject and ability for subject to comply with the requirements of the study

You may not qualify if:

• i. Current or past major psychiatric disorders (e.g. depression, anxiety disorders) or other major neurological disease ii. Current or past substance use problems iii. Serious head injury with loss of consciousness for ≥ 5 minutes iv. Fear of enclosed, confined spaces v. Pregnant or breastfeeding vi. Presence of active, recent, or repeated cancer vii. Unstable/undiagnosed medical conditions viii. Certain medications or conditions may impact the ability to participate and these will be discussed on a case by case basis with the study team.
• ix. Weight of more 158 kg x. Inability to remain still during the scans. xi. People for whom MRI is contra-indicated:
• People with a non-MRI safe intrauterine device (IUD);
• Machinist or Metalworkers;
• Cardiac pacemaker, wires or defibrillator;
• Past injury where a piece of metal lodged in your eye or orbit;
• Ferromagnetic aneurysm clip;
• Artificial heart valve;
• Brain aneurysm clip;
• Electrical stimulator for nerves or bones or brains;
• Ear or eye implant;
• Implanted drug infusion pump;
• Coil, catheter, or filter in any blood vessel;
• Orthopaedic hardware (artificial joint, plate, screws);
• Other metallic prostheses;

Sponsors & Collaborators

• Pacific Parkinson's Research Centre: lead
• University of British Columbia: collaborator

Study Sites (1)

UBC Pacific Parkinson's Research Centre

Vancouver, British Columbia, Canada

Location

MeSH Terms

Conditions

Parkinson Disease

Interventions

Positron-Emission Tomography; Magnetic Resonance Imaging

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Intervention Hierarchy (Ancestors)

Tomography, Emission-Computed; Image Interpretation, Computer-Assisted; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Image Enhancement; Photography; Radionuclide Imaging; Tomography; Diagnostic Techniques, Radioisotope

Study Officials

• Jess McKenzie

  Pacific Parkinson's Research Centre

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor & Head of Neurology

Study Record Dates

• First Submitted: May 3, 2021
• First Posted: May 6, 2021
• Study Start: January 25, 2021
• Primary Completion: November 27, 2023
• Study Completion: August 1, 2024
• Last Updated: October 26, 2024

Record last verified: 2023-11

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)