Parkinson's Disease Exercise TMS PET Study

NCT02265900 | Terminated

• 1 other identifier: H14-02200
• Study Type: interventional
• Target: 26
• Locations: 1 country
• Sites: 1

Brief Summary

The therapeutic effects of exercise in Parkinson's disease (PD) are commonly reported, however the mechanisms are unknown. The purpose of this study is to investigate the potential mechanisms of exercise in the brain for the treatment of PD.

Conditions

Parkinson Disease

Keywords

Positron Emission Tomography; Dopamine; Parkinson's Disease

Outcome Measures

Primary Outcomes (1)

• Change in Dopamine release measured by RAC PET

  4 months

Study Arms (2)

Exercise 1

ACTIVE COMPARATOR

One type of exercise

Other: Exercise

Exercise 2

PLACEBO COMPARATOR

A different type of exercise

Other: Exercise

Interventions

Exercise OTHER

One type of exercise

Exercise 1

Eligibility Criteria

• Age: 40 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may not qualify if:

• atypical Parkinson syndrome (progressive supranuclear palsy, multiple system atrophy, drug-induced etc.);
• significant osteoporosis or arthritis;
• other neurological disease/complications (e.g. myopathy, stroke, brain lesion, MS);
• self-reports claustrophobia;
• history of cancer within 5 years of study participation;
• high dose of radiation from other procedures within the year;
• not able to tolerate being off PD medication for up to 24 hours;
• a female subject who is breast-feeding or pregnant.
• Subjects who regularly use anti-inflammatories (only excluded for PBR scans).
• artificial heart valve;
• brain aneurysm clip;
• electrical stimulator for nerves or bones;
• ear or eye implant;
• implanted drug infusion pump;
• coil, catheter, or filter in any blood vessel;

Sponsors & Collaborators

• Pacific Parkinson's Research Centre: lead

Study Sites (1)

Pacific Parkinson's Research Centre

Vancouver, British Columbia, V6T 2B5, Canada

Location

MeSH Terms

Conditions

Parkinson Disease

Interventions

Exercise

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• A.J. Stoessl, MD

  Pacific Parkinson's Research Centre

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director of Clinical PET

Study Record Dates

• First Submitted: October 11, 2014
• First Posted: October 16, 2014
• Study Start: November 1, 2014
• Primary Completion: March 12, 2020
• Study Completion: March 12, 2020
• Last Updated: March 17, 2021

Record last verified: 2021-03

Locations

CA (1)