Single Exercise Bout in Parkinson's Disease (PD)

NCT03337464 | Completed

• 1 other identifier: H13-00084
• Study Type: interventional
• Target: 23
• Locations: 1 country
• Sites: 1

Brief Summary

To assess 30 active people (15 with PD, 15 without) before and after 30 minutes of pedaling exercise using EEG-EMG, cognitive, mood and motor assessments.

Conditions

Parkinson Disease

Keywords

exercise; EEG; EMG; Motor function; Mood; Cognition

Outcome Measures

Primary Outcomes (1)

• EEG-EMG coherence

  Coherence of the coupling between EEG and EMG from active leg muscles during cycling on a stationary bicycle both in subjects with PD and age and gender matched healthy controls.

  The change from immediately before, during, and immediatly after the single bout of exercise.

Secondary Outcomes (9)

• Motor function

  Immediately before and after the single bout of exercise.

• Motor function

  Immediately before and after the single bout of exercise.

• Motor function

  Immediately before and after the single bout of exercise.

• Motor function

  Immediately before and after the single bout of exercise.

• Cognitive function

  Immediately before, after and at 3 hours following the single bout of exercise.

Study Arms (2)

Parkinson's disease

EXPERIMENTAL

Subjects with Parkinson's disease

Other: cycling exercise

Control

ACTIVE COMPARATOR

Subjects without Parkinson's disease

Other: cycling exercise

Interventions

cycling exercise OTHER

5 x 3 minute bouts of cycling exercise separated by 3 minute rest periods

Control; Parkinson's disease

Eligibility Criteria

• Age: 40 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adult between 40-80 years
• Hoehn and Yahr stage I-III
• Exercise on a regular basis (at least 100 minutes of aerobic exercise per week)
• Montreal Cognitive Assessment score \>/= 24
• Able to communicate with study personnel
• Able to be informed of the nature of the study and willing to give written consent form

You may not qualify if:

• Hoehn and Yahr stages IV-V
• Significant cardiovascular disease
• Previous stroke
• Not exercising on a regular basis
• Functional disabling dyskinesia
• Functional disabling dystonia
• Smoker
• Significant neurological or psychiatric illness other than PD
• Dementia
• Severe depression
• Significant musculoskeletal disorder (e.g. arthritis)
• Significant metabolic disorder (e.g. diabetes)
• Brain surgery in the past
• Currently taking beta blocker medication

Sponsors & Collaborators

• Pacific Parkinson's Research Centre: lead

Study Sites (1)

Pacific Parkinson's Research Centre

Vancouver, British Columbia, V6T 2B5, Canada

Location

MeSH Terms

Conditions

Parkinson Disease; Motor Activity

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases; Behavior

Study Officials

• Silke Cresswell, MD

  Pacific Parkinson's Research Centre

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: The assessor will be blinded to subject group and intervention.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Director of PET

Model Details: 1 PD group and 1 one age matched non-PD subjects

Study Record Dates

• First Submitted: February 18, 2017
• First Posted: November 9, 2017
• Study Start: April 2, 2013
• Primary Completion: December 31, 2014
• Study Completion: December 31, 2014
• Last Updated: March 4, 2020

Record last verified: 2020-03

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)