Advanced MRI Scan Before and After Radiation Therapy for the Detection of Intracranial Metastasis
Advanced MRI for Intracranial Metastasis Treated With Stereotactic Radiosurgery
2 other identifiers
interventional
15
1 country
1
Brief Summary
This clinical trial studies the different types of investigational imaging techniques called sequences during magnetic resonance imaging (MRI) of the head before and after radiation therapy in patients with cancer that has spread to the brain (intracranial metastases). This clinical trial also compares these new techniques with standard MRI imaging to see if sequences provide better images. Diagnostic procedures, such as MRI, may help find and diagnose solid organ cancer and find out how far the disease has spread.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Mar 2021
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 30, 2021
CompletedFirst Submitted
Initial submission to the registry
April 26, 2021
CompletedFirst Posted
Study publicly available on registry
May 3, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 29, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
August 29, 2023
CompletedResults Posted
Study results publicly available
October 22, 2024
CompletedNovember 6, 2024
September 1, 2024
2.4 years
April 26, 2021
August 30, 2024
October 24, 2024
Conditions
Outcome Measures
Primary Outcomes (1)
Contrast to Noise Ratio
Contrast enhancement compared to baseline and normalized to background noise
Participants enrolled in the study were followed for variable amounts of times (up to 2 years and 4 months) from the date of their enrollment and baseline imaging
Study Arms (1)
Diagnostic (advanced MRI)
EXPERIMENTALPatients undergo conventional and advanced MRI over 60 minutes within 14 days before the start of scheduled brain radiation treatment. Patients then undergo 7 additional MRI over 60 minutes each between 4-16 weeks apart. Patients may receive gadolinium and/or iopamidol during MRI scans.
Interventions
Undergo advanced MRI
Undergo conventional MRI
Contrast agent
Eligibility Criteria
You may qualify if:
- An adult patient with pathology-proven solid organ cancer
- MRI of the brain with contrast, positive for at least one intra-axial metastatic lesion greater than 5 mm
- Planned treatment with stereotactic radiation
You may not qualify if:
- Contraindication to MR imaging
- Known allergy to gadolinium-based contrast agents
- Renal failure as defined by a glomerular filtration rate (GFR) less than 30 or the use of hemodialysis
- Pregnant
- Patients less than 18 years of age will be excluded
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- M.D. Anderson Cancer Centerlead
- National Cancer Institute (NCI)collaborator
Study Sites (1)
M D Anderson Cancer Center
Houston, Texas, 77030, United States
Related Links
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- Jason Johnson, MD
- Organization
- M D Anderson Cancer Center
Study Officials
- PRINCIPAL INVESTIGATOR
Jason M Johnson
M.D. Anderson Cancer Center
Publication Agreements
- PI is Sponsor Employee
- Yes
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- DIAGNOSTIC
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
April 26, 2021
First Posted
May 3, 2021
Study Start
March 30, 2021
Primary Completion
August 29, 2023
Study Completion
August 29, 2023
Last Updated
November 6, 2024
Results First Posted
October 22, 2024
Record last verified: 2024-09