Brain-Physical Optimization Conditioning

NCT04863469 | Unknown

• 1 other identifier: 2751
• Study Type: interventional
• Target: 66
• Locations: 1 country
• Sites: 1

Brief Summary

Brain-Physical Optimization Conditioning (B-POC) aims to enhance physical performance by expanding the traditional focus of endurance training from purely physical training to the domain of cognitive endurance (Staiano et al., 2015; Dallaway et al., 2017). The current study seeks to isolate neurocognitive mechanisms of performance, particularly under high stress (e.g., physical or cognitive load) conditions, and to develop corresponding cognitive optimization tools.

Conditions

Physical Performance

Keywords

cognitive fatigue; demand; endurance performance; perceived exertion; effort

Outcome Measures

Primary Outcomes (1)

• Time to Failure Test

  The Time to Failure Test (TFT) requires participants to run on a treadmill with increases in either grade (0.5% increase) and speed (\~0.3-0.5 mph) every two minutes in an alternating format for the first 16 minutes, after which settings remain constant until self termination of the exercise. The TFT settings (work rate) are calculated from an individual's last 2 mile run time. Physiological load (heart rate, oxygen consumption) and perceived exertion (RPE) are measured throughout the TFT. The primary outcome is change in time to failure (minutes, seconds) on the endurance test from baseline to post0test (\~7 weeks).

  7 weeks

Secondary Outcomes (1)

• Dynamic Marksmanship

  Pre-to-post ruck time (~30-90 minutes)

Study Arms (2)

B-POC high load Intervention

EXPERIMENTAL

aerobic exercise \[heartrate range (HRR) 70-75% of max HR, on treadmill\] and a computerized high-load task for 45 minutes, 3 times per week, for 6 weeks

Behavioral: B-POC high load intervention

B-POC low load intervention

SHAM COMPARATOR

aerobic exercise \[heartrate range (HRR) 70-75% of max HR, on treadmill\] and a computerized low-load task for 45 minutes, 3 times per week, for 6 weeks

Behavioral: B-POC low load intervention

Interventions

B-POC high load intervention BEHAVIORAL

aerobic exercise \[heartrate range (HRR) 70-75% of max HR, on treadmill\] and a computerized high-load task for 45 minutes, 3 times per week, for 6 weeks

B-POC high load Intervention

B-POC low load intervention BEHAVIORAL

aerobic exercise \[heartrate range (HRR) 70-75% of max HR, on treadmill\] and a computerized low-load task for 45 minutes, 3 times per week, for 6 weeks

B-POC low load intervention

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy active duty Soldiers
• years old
• Available for study duration

You may not qualify if:

• Failure of an Army Physical Fitness/Combat Test (APFT/ACFT) test
• On a physical profile that prevents them from 1) engaging in intense aerobic exercise, 2) running on a treadmill, 3) riding the stationary bike, and 4) performing a cognitive task on a computer screen.
• Medically non-deployable
• Impaired cognitive function due to medication, injury or illness,
• Have been advised by a medical professional not to engage in aerobic exercise
• Are a pregnant female

Sponsors & Collaborators

• Walter Reed Army Institute of Research (WRAIR): lead

Study Sites (1)

Medical Research Directorate - West

Tacoma, Washington, 98433, United States

RECRUITING

Central Study Contacts

Brad Fawver, PhD

CONTACT

253-968-4878; bradley.j.fawver.civ@mail.mil

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: FED
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 12, 2020
• First Posted: April 28, 2021
• Study Start: October 20, 2020
• Primary Completion: October 20, 2023
• Study Completion: October 20, 2025
• Last Updated: March 31, 2022

Record last verified: 2022-03

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)