NCT04859114

Brief Summary

Women recruited from the internet will be put in a hypothetical situation of being in labor at 22 weeks of pregnancy, and presented with information on the likelihood of survival and chance of disability for babies born at this gestational age. Participants will be randomized to receive this outcome data in one of three formats: as text-only, in a static pictograph, or in an iterative pictograph. Participants will also be randomized to seeing the chance of survival as 30% or 60%. Participants were then asked to choose between comfort care and intensive care in this situation. Participants' religiosity, value of the sanctity of life, and health literacy were also assessed.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,052

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Jun 2021

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

April 21, 2021

Completed
5 days until next milestone

First Posted

Study publicly available on registry

April 26, 2021

Completed
1 month until next milestone

Study Start

First participant enrolled

June 7, 2021

Completed
15 days until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 22, 2021

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 22, 2021

Completed
2.4 years until next milestone

Results Posted

Study results publicly available

November 24, 2023

Completed
Last Updated

November 24, 2023

Status Verified

November 1, 2023

Enrollment Period

15 days

First QC Date

April 21, 2021

Results QC Date

May 10, 2022

Last Update Submit

November 22, 2023

Conditions

Keywords

decision makingneonatal resuscitationrisk communicationprenatal counseling

Outcome Measures

Primary Outcomes (1)

  • Hypothetical Treatment Choice

    Participant's hypothetical treatment choice of either palliative care or intensive care. Participants are told: "If the child was actually born shortly after the conversation described above, which treatment would you prefer if you were in this situation?" and given the options of "Palliative care treatment" or "Intensive care treatment". This variable is assessed for the frequency of each option chosen.

    Assessed immediately post-intervention

Secondary Outcomes (3)

  • Values: Quality of Life or Sanctity of Life

    Assessed post-intervention, immediately after treatment choice.

  • Preference for Medical Autonomy

    Assessed post-intervention, immediately after treatment choice

  • Subjective Sense of Probability

    Assessed post-intervention, immediately after treatment choice.

Study Arms (6)

Text-only outcome data, 30% survival

ACTIVE COMPARATOR

Participants in this arm are provided a repeat of the outcome data in a text-only format, displaying a 30% chance of survival.

Behavioral: Format of outcome data presentationBehavioral: Displayed chance of survival

Text-only outcome data, 60% survival

ACTIVE COMPARATOR

Participants in this arm view a repeat of the outcome data in a text-only format, displaying a 60% chance of survival.

Behavioral: Format of outcome data presentationBehavioral: Displayed chance of survival

Static pictograph outcome data, 30% survival

EXPERIMENTAL

Participants in this arm view a static pictograph displaying the outcome data and showing a 30% chance of survival.

Behavioral: Format of outcome data presentationBehavioral: Displayed chance of survival

Static pictograph outcome data, 60% survival

EXPERIMENTAL

Participants in this arm view a static pictograph displaying the outcome data and showing a 60% chance of survival.

Behavioral: Format of outcome data presentationBehavioral: Displayed chance of survival

Iterative pictograph outcome data, 30% survival

EXPERIMENTAL

Participants in this arm view an iterative pictograph displaying the outcome data and showing a 30% chance of survival.

Behavioral: Format of outcome data presentationBehavioral: Displayed chance of survival

Iterative pictograph outcome data, 60% survival

EXPERIMENTAL

Participants in this arm view an iterative pictograph displaying the outcome data and showing a 60% chance of survival.

Behavioral: Format of outcome data presentationBehavioral: Displayed chance of survival

Interventions

Outcome data is provided to participants as either text-only, a static pictograph, or an iterative pictograph.

Iterative pictograph outcome data, 30% survivalIterative pictograph outcome data, 60% survivalStatic pictograph outcome data, 30% survivalStatic pictograph outcome data, 60% survivalText-only outcome data, 30% survivalText-only outcome data, 60% survival

In the outcome data provided to participants, they view either a 30% or 60% chance of survival.

Iterative pictograph outcome data, 30% survivalIterative pictograph outcome data, 60% survivalStatic pictograph outcome data, 30% survivalStatic pictograph outcome data, 60% survivalText-only outcome data, 30% survivalText-only outcome data, 60% survival

Eligibility Criteria

Age18 Years - 45 Years
Sexfemale(Gender-based eligibility)
Gender Eligibility DetailsThe survey was distributed only to women.
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Women who have:
  • had a child,
  • are currently of child-bearing age (defined as 18-45)
  • and who live in the U.S.

You may not qualify if:

  • Minors
  • Those unable to read English
  • Those who only could complete the survey on their phone. (For formatting purposes, a tablet or computer is necessary.)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States

Location

Related Publications (1)

  • McDonnell SM, Basir MA, Yan K, Liegl MN, Windschitl PD. Effect of Presenting Survival Information as Text or Pictograph During Periviable Birth Counseling: A Randomized, Controlled Trial. J Pediatr. 2023 Jun;257:113382. doi: 10.1016/j.jpeds.2023.02.026. Epub 2023 Mar 7.

MeSH Terms

Conditions

Premature Birth

Condition Hierarchy (Ancestors)

Obstetric Labor, PrematureObstetric Labor ComplicationsPregnancy ComplicationsFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital Diseases

Results Point of Contact

Title
Mir A Basir
Organization
Medical College of Wisconsin

Publication Agreements

PI is Sponsor Employee
No
Restrictive Agreement
No

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
OTHER
Intervention Model
FACTORIAL
Model Details: 2x3 between subjects
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor of Pediatrics

Study Record Dates

First Submitted

April 21, 2021

First Posted

April 26, 2021

Study Start

June 7, 2021

Primary Completion

June 22, 2021

Study Completion

June 22, 2021

Last Updated

November 24, 2023

Results First Posted

November 24, 2023

Record last verified: 2023-11

Data Sharing

IPD Sharing
Will not share

Locations