NCT04855669

Brief Summary

The investigators aimed to evaluate the impact of embryo distance from fundal endometrium, measured 60 minutes after transabdominal ultrasound guided embryo transfer(ET), on clinical pregnancy rates(CPR) and live birth rates(LBR) in fresh oocyte donation(OD) cycles.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
653

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jan 2016

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2016

Completed
5.3 years until next milestone

First Submitted

Initial submission to the registry

April 18, 2021

Completed
4 days until next milestone

First Posted

Study publicly available on registry

April 22, 2021

Completed
1 month until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2021

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

July 25, 2021

Completed
Last Updated

April 22, 2021

Status Verified

April 1, 2021

Enrollment Period

5.4 years

First QC Date

April 18, 2021

Last Update Submit

April 21, 2021

Conditions

Keywords

embryo migrationembryo transferfresh oocyte donation cyclelive birth rate

Outcome Measures

Primary Outcomes (1)

  • live birth rate

    In the literature, there are no studies performed in fresh OD cycles about air bubble and fundus distance after ET, and there are no studies performed whether there is any embryo migration after 60 minutes of ET and its effects on live birth rate outcome.

    1 year

Secondary Outcomes (1)

  • clinical pregnancy rate

    1 year

Eligibility Criteria

Age23 Years - 50 Years
Sexfemale(Gender-based eligibility)
Gender Eligibility Detailsthe study was performed with women who underwent embryo transfers
Healthy VolunteersNo
Age GroupsAdult (18-64)
Sampling MethodNon-Probability Sample
Study Population

The study included fresh OD cycles of recipient women.

You may qualify if:

  • fresh oocyte donation cycles
  • Anatomically anteverted-anteflexed recipient uterus
  • partners with normal sperm parameters

You may not qualify if:

  • Data of women who did not give approval
  • IVF cycles
  • frozen-thawed embryo transfer cycles
  • cryopreserved-thawed OD cycles
  • abnormal sperm parameters or need of any testicular interventions
  • Anatomically retroverted-retroflexed recipient uterus
  • teneculum required embryo transfers
  • difficult transfers

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Dunya In vitro fertilization center

Kyrenia, Cyprus

RECRUITING

Related Publications (3)

  • Saravelos SH, Wong AW, Chan CP, Kong GW, Cheung LP, Chung CH, Chung JP, Li TC. Assessment of the embryo flash position and migration with 3D ultrasound within 60 min of embryo transfer. Hum Reprod. 2016 Mar;31(3):591-6. doi: 10.1093/humrep/dev343. Epub 2016 Jan 11.

  • Ficicioglu C, Ozcan P, Kocer MG, Yesiladali M, Alagoz O, Ozkara G, Tayyar AT, Altunok C. Effect of air bubbles localization and migration after embryo transfer on assisted reproductive technology outcome. Fertil Steril. 2018 Feb;109(2):310-314.e1. doi: 10.1016/j.fertnstert.2017.10.032. Epub 2018 Jan 4.

  • Ozdemir AZ, Ayas B, Guven D, Turkmen A. Embryo flash migration in fresh and frozen embryo transfers for day 3 and day 5 embryos. Eur J Obstet Gynecol Reprod Biol. 2019 Jul;238:33-37. doi: 10.1016/j.ejogrb.2019.04.025. Epub 2019 May 4.

MeSH Terms

Conditions

Infertility

Condition Hierarchy (Ancestors)

Genital DiseasesUrogenital Diseases

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Investigator

Study Record Dates

First Submitted

April 18, 2021

First Posted

April 22, 2021

Study Start

January 1, 2016

Primary Completion

June 1, 2021

Study Completion

July 25, 2021

Last Updated

April 22, 2021

Record last verified: 2021-04

Locations