NEUROIMAGING OF ADOLESCENT BORDERLINE PERSONALITY DISORDER WITH AND WITHOUT POST-TRAUMATIC STRESS DISORDER

NCT04852744 | Recruiting DMC

• 1 other identifier: 2019-A00366-51
• Study Type: interventional
• Target: 99
• Locations: 1 country
• Sites: 1

Brief Summary

Borderline personality disorder (BPD) is a common mental disorder in adolescents with significant individual and societal repercussions, characterized over the long term by emotional hyperresponsiveness, relational instability, identity disturbances and self-aggressive behavior. The etiology of BPD is multifactorial and involves exposure to traumatic life events, which are present in the majority of cases. This explains the very common co-morbidity between BPD and post-traumatic stress disorder (PTSD), which involves emotionally painful memory relapses of one or more traumatic events, associated with an emotional trauma avoidance syndrome (s). ) and hypervigilance. Brain imaging studies in adolescents with BPD have shown decreases in the volume of gray matter within the frontolimbic network, as well as a decrease in frontolimbic white matter bundles. These brain changes are considered to be biological markers of TPB. However, the exact same brain changes are seen in PTSD. Although it represents more than a third of adolescents hospitalized in psychiatry, neuroscientific studies of BPD in adolescence are still scarce. The expertise we have acquired in U1077 in adolescents with PTSD offers us an exceptional opportunity to characterize in BPD with and without PTSD structural anomalies, including the hippocampus, and functional at rest, never used for hour in the teenager's BPD. Beyond that, carrying out an 18-month follow-up of the patients will allow us to assess the predictive value of these anomalies on the level of general psychopathology in all the patients studied and the intensity of the symptoms of traumatic relapse in the patients with PTSD. This modeling of disorders integrating psychopathological, neuropsychological and neuroanatomical approaches will provide the clinician with new knowledge necessary for therapeutic innovation.

Conditions

Borderline Personality Disorder

Keywords

Adolescence; Hippocampus; Neuropsychology; Borderline personality disorder; Post-traumatic stress disorder

Outcome Measures

Primary Outcomes (1)

• Hippocampal volume

  during the month following inclusion

Study Arms (3)

Borderline girls with PTSD

OTHER

* female * Age between 13 and 17 years inclusive * Diagnosis of borderline personality disorder according to the criteria of the Diagnostic and Statistical Manual for mental disorders, fifth edition (DSM-5; American Psychiatric Association, 2013; SIDP-IV) * Post-traumatic stress disorder according to DSM-5 criteria (American Psychiatric Association, 2013; K-SADS-PL) * Level of general psychopathology compatible with participation in the study (score\> 20 on the CGA-S) * Oral and written comprehension of the French language * Affiliation to the social security scheme * Informed consent signed by the legal representatives holding the exercise of parental authority and the adolescent herself

Other: Brain MRI

Borderline girls without PTSD

OTHER

* female * Age between 13 and 17 years inclusive * Diagnosis of borderline personality disorder according to the criteria of the Diagnostic and Statistical Manual for mental disorders, fifth edition (DSM-5; American Psychiatric Association, 2013; SIDP-IV) * Level of general psychopathology compatible with participation in the study (score\> 20 on the CGA-S) * Oral and written comprehension of the French language * Affiliation to the social security scheme * Informed consent signed by the legal representatives holding the exercise of parental authority and the adolescent herself

Other: Brain MRI

Healthy controls

OTHER

* female * Age between 13 and 17 years inclusive * Absence of mental disorder according to DSM-5 (American Psychiatric Association, 2013 ; K-SADS-PL et SIDP-IV) * Oral and written comprehension of the French language * Affiliation to the social security scheme * Informed consent signed by the legal representatives holding the exercise of parental authority and the adolescent herself

Other: Brain MRI

Interventions

Brain MRI OTHER

Anatomical MRI The anatomical data will be acquired by means of a 3T Signa Premier General Electric Healthcare MRI, allowing the acquisition of classic anatomical sequences (T1, T2) and a high-resolution hippocampal sequence allowing to accurately apprehend its various sub-fields. (total acquisition time: 10 min). The hippocampal volume, the orbital-frontal cortex and the cingulate cortex will be measured by voxel-based morphometry (VBM; Ashburner \& Friston, 2000\]) using the SPM software (Statistical Parametric Mapping; Friston et al., 2006). The voxel-by-voxel morphometric analysis of T1 MRI images makes it possible to classify and segment the different brain tissues (gray matter versus white matter) and to analyze the focal differences in volume within these tissues between the different groups.

Also known as: Psychological and behavioural assessment

Borderline girls with PTSD; Borderline girls without PTSD; Healthy controls

Eligibility Criteria

• Age: 13 Years - 18 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• For the 3 groups:
• female
• Age between 13 and 17 years inclusive
• Oral and written comprehension of the French language
• Affiliation to the social security scheme
• Informed consent signed by the legal representatives holding the exercise of parental authority and the adolescent herself
• For patients:
• Diagnosis of borderline personality disorder according to the criteria of the Diagnostic and Statistical Manual for mental disorders, fifth edition (DSM-5; American Psychiatric Association, 2013; SIDP-IV)
• Level of general psychopathology compatible with participation in the study (score\> 20 on the CGA-S)
• TB + / PTSD + group:
• \- Post-traumatic stress disorder according to DSM-5 criteria (American Psychiatric Association, 2013; K-SADS-PL)
• In the control group :
• Absence of mental disorder according to DSM-5 criteria (American Psychiatric Association, 2013; K-SADS-PL and SIDP-IV)
• Oral and written comprehension of the French language
• Informed consent signed by the legal representative, the holder (s) of the exercise of parental authority and the adolescent herself

You may not qualify if:

• \- Illiteracy / illiteracy
• Sensory disorder (visual, auditory)
• Severe chronic psychiatric comorbidity: autism spectrum disorder, intellectual disability, schizophrenia spectrum disorder and other psychotic disorders, bipolar disorder
• Severe or current brain pathology (chronic neurological disease, encephalitis, history of severe head trauma), alertness disorder
• History of anoxic coma
• Contraindication to MRI (magnetic foreign body, claustrophobia, contraindication to prolonged lying down)
• Severe physical pathology in progress
• Moving outside the Normandy region planned within 18 months
• Intellectual deficit (IQ \<70)
• Pregnant or breastfeeding women

Sponsors & Collaborators

• University Hospital, Caen: lead
• CHU de Rouen - Accueil: collaborator
• Centre Hospitalier Universitaire de Caen: collaborator
• Université de Caen Normandie: collaborator
• Centre Hospitalier du Rouvray: collaborator
• Institut National de la Santé Et de la Recherche Médicale, France: collaborator
• Groupe Hospitalier du Havre: collaborator

Study Sites (1)

Caen University Hospital

Caen, France

RECRUITING

MeSH Terms

Conditions

Borderline Personality Disorder; Stress Disorders, Post-Traumatic

Condition Hierarchy (Ancestors)

Personality Disorders; Mental Disorders; Stress Disorders, Traumatic; Trauma and Stressor Related Disorders

Central Study Contacts

Fabian Guénolé, Pr.

CONTACT

+33 (0) 231 272 309; guenole-f@chu-caen.fr

Bérengère Guillery-Girard, Ass.Pr.

CONTACT

+33 (0) 231 568 399; berengere.guillery@unicaen.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 16, 2021
• First Posted: April 21, 2021
• Study Start: March 11, 2022
• Primary Completion (Estimated): December 1, 2027
• Study Completion (Estimated): June 1, 2028
• Last Updated: July 25, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)