Incidence of Snakebite Associated Thrombotic Microangiopathy & Role of Peripheral Blood Smear as a Predictor of Clinical Outcome

NCT04845022 | Unknown DMC

• 1 other identifier: 16/21/IEC/JMMC&RI
• Study Type: observational
• Target: 81
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to find the overall incidence of thrombotic microangiopathy in snakebite victims. As we know snakebite is a common in tropical regions. Many a times the early diagnosis of TMA is missed and precious time which could have helped in improving the patient prognosis is lost. Also via this study we wish to learn the role of cost effective test like peripheral smear which could help learn morphological picture of red blood cells and thus help in early prediction of patients clinical prognosis.

Conditions

SNAKEBITE; THROMBOTIC MICROANGIOPATHY; SCHISTOCYTES

Keywords

TMA, Peripheral blood smear(PBS)

Outcome Measures

Primary Outcomes (1)

• To find the number of peripheral smear samples of TMA snakebite in which schistocyte grading helps in predicting the patient clinical outcome

  To find the number of PBS smears in which morphological evaluation of RBC in PBS examination helps in predicting clinical outcome in snakebite associated TMA

  1 year

Secondary Outcomes (1)

• To find the number of hematotoxic snakebites associated with thrombotic microangiopathy (TMA) cases within 7days of admission

  1 year

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All snakebite victims who meet the inclusion criteria would be included in the study

You may qualify if:

• All patients with a history of snakebite and with prolonged WBCT.

You may not qualify if:

• Patients administered with blood or blood components prior to admission
• Known case of bleeding disorders
• Known case of haemolytic anaemia
• Patients on antiplatelets or anticoagulants

Sponsors & Collaborators

• Jubilee Mission Medical College and Research Institute: lead

Study Sites (1)

Jubilee Mission Medical College

Thrissur, Kerala, 680005, India

RECRUITING

MeSH Terms

Conditions

Snake Bites; Thrombotic Microangiopathies; Sickle Cell Trait

Condition Hierarchy (Ancestors)

Bites and Stings; Poisoning; Chemically-Induced Disorders; Wounds and Injuries; Thrombocytopenia; Blood Platelet Disorders; Hematologic Diseases; Hemic and Lymphatic Diseases; Cytopenia; Anemia, Sickle Cell; Anemia, Hemolytic, Congenital; Anemia, Hemolytic; Anemia; Hemoglobinopathies; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Study Officials

• Aboobacker Rafi, MD

  Jubilee Mission Medical College and Research Institute

  STUDY CHAIR

Central Study Contacts

Maglin Tomy, MD

CONTACT

9895731303; maglinmonica@gmail.com

Dr.Siju Abraham

CONTACT

9447754321; sijuvabraham@jmmc.ac.in

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Junior Resident

Study Record Dates

• First Submitted: April 10, 2021
• First Posted: April 14, 2021
• Study Start: January 28, 2021
• Primary Completion: June 30, 2022
• Study Completion: January 1, 2023
• Last Updated: June 14, 2021

Record last verified: 2021-06

Locations

IN (1)