Mapping Snakebite Risk in Kenya and Eswatini

NCT06124872 | Unknown

• 1 other identifier: 22_060
• Study Type: observational
• Target: 70,000
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to learn about how snakebite risk varies in different environments in Kenya and understand how this information can be used to support decision makers. The main questions it aims to answer are:

1. 1.To what extent can information on snakebite cases and data on geographic, climatic and sociodemographic factors be used to predict geographical variation in snakebite risk in Kenya and Eswatini?
2. 2.What is the most effective means of presenting outputs from spatial analysis of snakebite risk to ensure its effective use in research and healthcare decision making?

Conditions

Snakebite; Epidemiology

Outcome Measures

Primary Outcomes (3)

• Geostatistical model of snakebite risk in Kenya and Eswatini

  A geostatistical model of snakebite risk, detailing the statistical association between selected covariates and snakebite risk, based on analysis of data on snakebite incidence collected from contrasting locations in Kenya and Eswatini.

  Through study completion, estimated end of 2024

• An assessment of the accuracy of snakebite incidence data reported from routine surveillance systems relative to community survey estimates

  An assessment of the accuracy of routine surveillance data sources in relation to community survey incidence estimates (the gold standard measure) in each study location.

  Through study completion, estimated end of 2024

• Recommendations

  A thematic analysis of key informant interviews on the potential role of and key features needed in snakebite risk maps in order for them to provide utility in healthcare decision making and a set of recommendations to guide presentation of spatial outputs on snakebite risk.

  Through study completion, estimated end of 2024

Study Arms (4)

Community survey 1 (planned demographic/health survey)

Households included in a planned demographic and health survey (DSS). All participants included in this survey will be invited to respond to snakebite questions.

Other: Survey questionnaire

Community survey 2 (Stand alone survey)

25 households randomly selected for inclusion within each survey cluster. Survey clusters will be randomly selected enumeration units within study Counties.

Other: Survey questionnaire

Community survey 3 (Stand alone survey)

25 households randomly selected for inclusion within each survey cluster. Survey clusters will be randomly selected enumeration units within study Counties.

Other: Survey questionnaire

Key informant interviews

Stakeholders in the process of healthcare decision making and research relevant to snakebite and snakebite envenoming

Other: Key informant interview

Interventions

Survey questionnaire OTHER

Household screening questionnaire Snakebite details questionnaire where a history of snakebite is reported

Community survey 1 (planned demographic/health survey); Community survey 2 (Stand alone survey); Community survey 3 (Stand alone survey)

Key informant interview OTHER

Semi-structured interview with selected key informants

Key informant interviews

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Community surveys * Populations resident within selected counties. Key informant interviews: * Those with power and/or influence in healthcare decision making or research with relation to Neglected Tropical Diseases/snakebite.

You may qualify if:

• Household Screening Questionnaire:
• All heads of household from randomly selected households.
• To account for all household members
• Snakebite Details Questionnaire:
• All household members with a history of snakebite. If the household member is deceased, a responsible adult from the household will be asked to complete the questionnaire.
• Key informant interviews:
• Key informants identified through a stakeholder mapping exercise as having power and/or influence in healthcare decision making or research with relation to Neglected Tropical Diseases/snakebite.
• Willing and motivated to be interviewed

You may not qualify if:

• Household Screening Questionnaire:
• Households where the household head/a responsible adult is not present at first visit or revisit.
• Household where the household head/responsible adult is unable or unwilling to give consent
• Snakebite Details Questionnaire:
• The household member is unable/unwilling to give consent and (in the case of the former) there is no responsible adult available/willing to complete the questionnaire on their behalf
• Key informant interviews:
• A participant whose role and organisation has already been represented in the key informant interviews
• Participant declines to be interviewed

Sponsors & Collaborators

• Liverpool School of Tropical Medicine: lead
• Kenya Medical Research Institute: collaborator
• Institute of Primate Research: collaborator

Study Sites (1)

KSRIC

Nairobi, Kenya

Location

MeSH Terms

Conditions

Snake Bites

Interventions

Surveys and Questionnaires

Condition Hierarchy (Ancestors)

Bites and Stings; Poisoning; Chemically-Induced Disorders; Wounds and Injuries

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Officials

• Collinson

  Liverpool School of Tropical Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 3, 2023
• First Posted: November 9, 2023
• Study Start: June 1, 2023
• Primary Completion: December 31, 2024
• Study Completion: December 31, 2024
• Last Updated: November 9, 2023

Record last verified: 2023-10

Data Sharing

• IPD Sharing: Will share
• Shared Documents: ANALYTIC CODE
• Time Frame: following study completion and publication of key study outputs

Locations

KE (1)