Off-Pump and On-Pump Techniques and Oxidative Stress in CABG Surgery

NCT04834219 | Completed DMC

• 1 other identifier: 189_2020.01.18_15
• Study Type: observational
• Target: 64
• Locations: 1 country
• Sites: 1

Brief Summary

CABG (coronary artery bypass graft) surgery is among the most common heart surgeries performed in the heart pump. In CABG surgery, operations performed on the beating heart without the use of CPB (off-pump) are frequently performed (30-60%) (1). To the best of our knowledge, there has been no study examining cerebral oxygenation values, oxidative stress levels and postoperative results in CABG operations.

Conditions

Cerebral Oxygenation; Oxidative Stress; Myocardial Infarction

Keywords

Coronary artery bypass surgery; Oxidative stress; Cerebral oxygenation

Outcome Measures

Primary Outcomes (4)

• Oxidative stress level

  Oxidative stress biomarker levels between on-pump and off-pump coronary artery bypass groups

  Intraoperative period

• TAS

  Total antioxidant status

  Intraoperative period

• TOS

  Total oxidant status

  Intraoperative period

• SOD

  Superoxide dismutase

  Intraoperative period

Secondary Outcomes (1)

• Cerebral oximetry

  Intraoperative period

Study Arms (2)

On-pump CABG

Patients with an on-pump indication by the cardiovascular surgery department will be included in the study.

Procedure: On-Pump CABG; Procedure: Off-Pump CABG

Off-pump CABG

Patients with an off-pump indication by the cardiovascular surgery department will be included in the study.

Procedure: On-Pump CABG; Procedure: Off-Pump CABG

Interventions

On-Pump CABG PROCEDURE

Patients who have undergone on-pump Coronary artery bypass grafting (CABG) surgery are planned by the Department of Cardiovascular Surgery.

Off-pump CABG; On-pump CABG

Off-Pump CABG PROCEDURE

Patients who have undergone off-pump Coronary artery bypass grafting (CABG) surgery are planned by the Department of Cardiovascular Surgery.

Off-pump CABG; On-pump CABG

Eligibility Criteria

• Age: 30 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

It is planned to participate in this prospective observational study of 64 volunteer patients undergoing Coronary artery bypass grafting (CABG) surgery by the Department of Cardiovascular Surgery.

You may qualify if:

• Undergo CABG surgery with on-pump and off-pump technique,
• Volunteer to participate in the study,
• years old

You may not qualify if:

• Those with chronic kidney failure
• Those with liver failure
• Under 30 and over 80

Sponsors & Collaborators

• Bozok University: lead

Study Sites (1)

Bozok University Medical Center

Yozgat, Turkey (Türkiye)

Location

Related Publications (1)

• Hussain G, Azam H, Baig MA, Ahmad N. Early outcomes of on-pump versus off-pump coronary artery bypass grafting. Pak J Med Sci. 2016 Jul-Aug;32(4):917-21. doi: 10.12669/pjms.324.9680.

  PMID: 27648039 RESULT

MeSH Terms

Conditions

Myocardial Infarction

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Study Officials

• Ökkeş Hakan Miniksar, Asist.Prof

  YOZGAT BOZOK UNIVERSITY

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Target Duration: 6 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: April 2, 2021
• First Posted: April 8, 2021
• Study Start: January 15, 2021
• Primary Completion: September 15, 2021
• Study Completion: September 24, 2021
• Last Updated: September 28, 2021

Record last verified: 2021-09

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)