Thiol Disulfide Balance and Oxidative Stress Change in Endometrial Polyp Patients
1 other identifier
observational
54
1 country
1
Brief Summary
Changes in Thiol Disulfide Balance and Oxidative Stress Mechanisms in Patients with Endometrial Polyps
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Jan 2021
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 2, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 3, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
January 5, 2022
CompletedFirst Submitted
Initial submission to the registry
February 7, 2025
CompletedFirst Posted
Study publicly available on registry
February 14, 2025
CompletedFebruary 14, 2025
February 1, 2025
1 year
February 7, 2025
February 12, 2025
Conditions
Outcome Measures
Primary Outcomes (9)
Oxidative stress markers
Total antioxidant status (μmol Trolox equivalent/ L)
From January 2021 to January 2022
Oxidative stress markers
Total oxidant status (μmol H2O2 equivalent/L)
From January 2021 to January 2022
Oxidative stress markers
Oxidative stress index (arbitrary unit)
From January 2021 to January 2022
Oxidative stress markers
Paraoxonase (U/L)
From January 2021 to January 2022
Oxidative stress markers
Arylesterase (Ku/l)
From January 2021 to January 2022
Oxidative stress markers
Total thiol (µmol / L)
From January 2021 to January 2022
Oxidative stress markers
Native thiol (µmol / L) / alb (g / l)
From January 2021 to January 2022
Oxidative stress markers
Disulfide (-S-S-) (µmol / L) / alb (g/l)
From January 2021 to January 2022
Oxidative stress markers
Ischemia-modified albumin (u/L)
From January 2021 to January 2022
Study Arms (2)
endometrial polyps
Women with endometrial polyp
control group
Participants in the control group were confirmed to be free of endometrial polyps via TVUSG and saline infusion ultrasonography
Eligibility Criteria
A total of fifty-four participants, aged 20 to 48, took part in the study, including twenty-four women diagnosed with endometrial polyps and thirty women as the control group.
You may qualify if:
- For participants in the control group:
- To be without endometrial polyp
- For the polyp group, they were as follows:
- Individuals experiencing menometrorrhagia
- A body mass index (BMI) of 25 or more
- Hypertension
- Endometrial polyps detected via saline infusion ultrasonography
You may not qualify if:
- Pregnancy
- Diabetes mellitus
- Pelvic mass
- Malignancy
- The use of Tamoxifen, hormonal contraceptives, or hormone replacement therapy.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Alanya Training and Research Hospital Gynecology and Obstetrics Department
Antalya, Turkey (Türkiye)
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor
Study Record Dates
First Submitted
February 7, 2025
First Posted
February 14, 2025
Study Start
January 2, 2021
Primary Completion
January 3, 2022
Study Completion
January 5, 2022
Last Updated
February 14, 2025
Record last verified: 2025-02