NCT04827693

Brief Summary

To evaluate a novel technique of bone regeneration and simultaneous implant placement in severely damaged sockets.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
34

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Jan 2019

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 3, 2019

Completed
2.2 years until next milestone

First Submitted

Initial submission to the registry

March 29, 2021

Completed
2 days until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 31, 2021

Completed
1 day until next milestone

First Posted

Study publicly available on registry

April 1, 2021

Completed
4 days until next milestone

Study Completion

Last participant's last visit for all outcomes

April 5, 2021

Completed
Last Updated

April 8, 2021

Status Verified

April 1, 2021

Enrollment Period

2.2 years

First QC Date

March 29, 2021

Last Update Submit

April 5, 2021

Conditions

Keywords

tooth socketbone graftingbone regenerationdental implantosseointegration

Outcome Measures

Primary Outcomes (1)

  • Individuals presenting alveolar Facial Bone regeneration at re-entry

    Bone regeneration of the dent-alveolar socket

    1 year

Secondary Outcomes (4)

  • Pink Esthetic Scores

    1 year

  • Facial implant transparency

    1 year

  • Band of Keratinized tissue

    1 year

  • Implant crestal bone loss

    1 year

Study Arms (2)

Immediate

implants are placed immediately after tooth extraction

Delayed

implants are placed months after the tooth has been extracted

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients requiring single implants to replace missing teeth to restore masticatory function and esthetics. Options of immediate or delay placement will be chosen based on the current status of the site to be restored at the time of referral. The present cross-sectional quasi-experimental study is conducted in a specialty clinic in accordance to the requirements of the 1964 Helsinki Declaration

You may qualify if:

  • ASA1 or ASA2 (American Society of Anesthesiologists)
  • Healthy individuals with good oral hygiene and motivation
  • No systemic uncontrolled diseases
  • Not taking drugs known to modify bone metabolism

You may not qualify if:

  • Individuals with untreated \& generalized severe periodontitis
  • Heavy smokers (\>10 cigarettes/day)
  • Poor oral hygiene
  • Diabetes (HbA1C \>6.5% as cutoff value)
  • Uncontrolled cardiovascular disease
  • Poor overall health (ASA IV)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Fernando Verdugo, DDS, Corp

Los Angeles, California, 90077, United States

Location

MeSH Terms

Conditions

Tooth LossTooth DiseasesTooth FracturesTooth InjuriesAlveolar Bone LossPeriodontitisPeri-ImplantitisDental Caries

Condition Hierarchy (Ancestors)

Periodontal DiseasesMouth DiseasesStomatognathic DiseasesWounds and InjuriesBone ResorptionBone DiseasesMusculoskeletal DiseasesPeriodontal AtrophyTooth Demineralization

Study Officials

  • Fernando Verdugo, PhD

    University of Sacro Cuore

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
INDIV
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 29, 2021

First Posted

April 1, 2021

Study Start

January 3, 2019

Primary Completion

March 31, 2021

Study Completion

April 5, 2021

Last Updated

April 8, 2021

Record last verified: 2021-04

Data Sharing

IPD Sharing
Will not share

Locations