Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)
ESSENCE
The Effect of Semaglutide in Subjects With Non-cirrhotic Non-alcoholic Steatohepatitis
4 other identifiers
interventional
1,205
38 countries
544
Brief Summary
Semaglutide is a medicine studied in patients with NASH. Semaglutide is a well-known medicine, which is already used by doctors to treat type 2 diabetes in many countries. Participants will either get semaglutide or a dummy medicine - which treatment participants get is decided by chance. Participants will need to inject themselves with medicine under the skin. Participants will need to do this once a week. The study will last for about 5 years. Participants will have up to 21 clinic visits and 9 phone calls with the clinical staff during the study. Some of the clinic visits may be spread over more than one day. Participants with other chronic liver diseases cannot take part in this study. Women cannot take part in the study if they are pregnant, breast-feeding or plan to become pregnant during the study period.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started Apr 2021
Longer than P75 for phase_3
544 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 26, 2021
CompletedFirst Posted
Study publicly available on registry
March 30, 2021
CompletedStudy Start
First participant enrolled
April 1, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 25, 2029
ExpectedStudy Completion
Last participant's last visit for all outcomes
April 25, 2029
April 17, 2026
April 1, 2026
8.1 years
March 26, 2021
April 16, 2026
Conditions
Outcome Measures
Primary Outcomes (3)
Part 1: Resolution of steatohepatitis and no worsening of liver fibrosis (Yes/No)
Count of subject
From randomisation (week 0) to week 72
Part 1: Improvement in liver fibrosis and no worsening of steatohepatitis (Yes/No)
Count of subject
From randomisation (week 0) to week 72
Part 2: Cirrhosis-free survival (Yes/No)
Count of subject
From randomisation (week 0) to week 240
Secondary Outcomes (35)
Change in body weight
From randomisation (week 0) to week 72
Resolution of steatohepatitis and improvement in liver fibrosis (Yes/No)
From randomisation (week 0) to week 72
Change in SF-36 (Short Form 36) Bodily Pain
From randomisation (week 0) to week 72
Change in body weight
From randomisation (week 0) to week 240
Improvement in steatohepatitis with at least a 2-point reduction in NAS and no worsening of fibrosis (Yes/No)
From randomisation (week 0) to week 72
- +30 more secondary outcomes
Study Arms (2)
Semaglutide OW (once weekly )
EXPERIMENTALSemaglutide administrated subcutaneously once weekly
Placebo
PLACEBO COMPARATORPlacebo administrated subcutaneously once weekly
Interventions
Semaglutide administrated subcutaneously (under the skin) once weekly there will be a period of dose escalation before reaching the target dose.
Eligibility Criteria
You may qualify if:
- Age above or equal to 18 years at the time of signing informed consent.
- Histological evidence of NASH based on a central pathologist evaluation of the baseline liver biopsy. The baseline liver biopsy can be a historical biopsy obtained within 180 days prior to the screening visit (V1).
- Histological evidence of fibrosis stage 2 or stage 3 according to the NASH CRN (Clinical Research Network) classification based on a central pathologist evaluation of the baseline liver biopsy.
- A histological NAS (Non-alcoholic fatty liver disease Activity Score) above or equal to 4 with a score of 1 or more in steatosis, lobular inflammation and hepatocyte ballooning based on a central pathologist evaluation of the baseline liver biopsy.
You may not qualify if:
- Documented causes of chronic liver disease other than non-alcoholic fatty liver disease (NAFLD)
- Positive HBsAg, positive anti-HIV, positive HCV RNA at screening (V2A) or any known presence of HCV RNA or HBsAg within 2 years of screening (V2A).
- Presence or history of ascites, variceal bleeding, hepatic encephalopathy, spontaneous bacterial peritonitis or liver transplantation at randomisation.
- Known or suspected excessive consumption of alcohol (greater than 20 g/day for women or greater than 30 g/day for men) or alcohol dependence (assessed by the Alcohol Use Disorders Identification Test (AUDIT questionnaire)).
- Treatment with vitamin E (at doses greater than or equal to 800 IU/day) or pioglitazone or medications approved for treatment of NASH which has not been at a stable dose in the period from 90 days prior to the screening visit (V2A). In addition, for subjects with historical liver biopsies taken more than 90 days prior to screening, treatment should be at a stable dose from time of biopsy until screening.
- Treatment with GLP-1 RAs in the period from 90 days prior to the screening visit (V2A). In addition, for subjects with historical liver biopsies taken more than 90 days prior to screening, any treatment with GLP-1 RAs from time of biopsy until screening (V2A).
- Treatment with glucose-lowering agent(s) (other than GLP-1 RAs), lipid-lowering medication or weight loss medication not stable in the opinion of the investigator in the period from 90 days prior to the screening visit (V2A). In addition, for subjects with historical liver biopsies taken more than 90 days prior to screening, treatment should be at a stable dose in the opinion of the investigator from time of biopsy until screening.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Novo Nordisk A/Slead
Study Sites (556)
North AL Health Res, LLC
Huntsville, Alabama, 35801, United States
The Institute for Liver Health
Chandler, Arizona, 85224, United States
Inst-Liver Hlth dba AZ Liver H
Peoria, Arizona, 85381, United States
Inst. Liver H II dba AZ Liver H
Tucson, Arizona, 85712, United States
Del Sol Research Management, LLC
Tucson, Arizona, 85715, United States
ARcare Center for Clinical Research
Jonesboro, Arkansas, 72401, United States
ARcare Center for Clinical Research
Little Rock, Arkansas, 72205, United States
Arkansas Diagnostic Center, PA
Little Rock, Arkansas, 72205, United States
Gastroenterology & Liver Institute
Escondido, California, 92025, United States
Shang Wu M.D. Inc.
Hacienda Heights, California, 91745, United States
Scripps Whittier Diabetes Inst
La Jolla, California, 92037, United States
UCSD NAFLD Research Center
La Jolla, California, 92037, United States
OM Research LLC
Lancaster, California, 93534, United States
Digestive Hlth Res of SoCa
Long Beach, California, 90808, United States
OM Research LLC
Oxnard, California, 93030, United States
Cedars-Sinai Medical Center
Pasadena, California, 90048, United States
Pasedena Liver Center
Pasadena, California, 91105, United States
Inland Empire Clin Trials LLC
Rialto, California, 92377, United States
UC Davis Hlth -Midtwn Ambu Cen
Sacramento, California, 95817, United States
University of California, San Francisco
San Francisco, California, 94143, United States
Silicon Valley Res Inst
San Jose, California, 95116, United States
Peak Gastro Assoc-Col Springs
Colorado Springs, Colorado, 80907, United States
Yale Ctr for Clin Invest
New Haven, Connecticut, 06519, United States
Encore Medical Research of Boynton Beach LLC
Boynton Beach, Florida, 33436, United States
Integrity Clinical Research, LLC
Doral, Florida, 33122, United States
Covenant Metabolic Specialists, Ft. Myers
Fort Myers, Florida, 33912, United States
University of Florida-CTRB
Gainesville, Florida, 32610, United States
Miguel Rebollar PA
Hialeah, Florida, 33012, United States
Direct Helpers Research Center
Hialeah, Florida, 33016, United States
Florida Research Institute, LLC
Lakewood Rch, Florida, 34211-4930, United States
Sandhill Research, LLC
Maitland, Florida, 32751, United States
Tandem Clinical Research - Maitland
Maitland, Florida, 32751, United States
Optimus U, Corp
Miami, Florida, 33135, United States
Univ of Miami/Schiff Ctr
Miami, Florida, 33136, United States
Genoma Research Group, Inc
Miami, Florida, 33173, United States
IMIC Inc
Miami, Florida, 33176, United States
San Marcus Res Clin Miami Lakes
Miami Lakes, Florida, 33014, United States
Ocala GI Research
Ocala, Florida, 34471, United States
Sensible Healthcare LLC
Ocoee, Florida, 34761, United States
Covenant Metabolic Specialists LLC
Sarasota, Florida, 34240, United States
Headlands Research - Sarasota
Sarasota, Florida, 34243, United States
Theia Clinical Research Centers LLC
St. Petersburg, Florida, 33710, United States
ClinCloud, LLC
Viera E., Florida, 32940, United States
Florida Medical Clinic Orlando Health
Zephyrhills, Florida, 33542, United States
Emory University Hospital
Atlanta, Georgia, 30322-1059, United States
Columbus Regional Research Institute
Columbus, Georgia, 31904, United States
Gastroenterology Assoc_ CGA
Macon, Georgia, 31201, United States
Gastroint Spec of Georgia
Marietta, Georgia, 30060, United States
Rush University Med. Cntr
Chicago, Illinois, 60612, United States
University Of Chicago
Chicago, Illinois, 60637, United States
Endeavor Health
Skokie, Illinois, 60077, United States
Indiana University Hospital
Indianapolis, Indiana, 46202, United States
Digestive Research Alliance of Michiana
South Bend, Indiana, 46635, United States
Iowa Digestive Disease Center
Clive, Iowa, 50325, United States
University Of Kansas Hospital
Kansas City, Kansas, 66160, United States
Kansas Medical Clinic, PA
Topeka, Kansas, 66606, United States
Tandem Clinical Research - Houma
Houma, Louisiana, 70363, United States
Tandem Clinical Research
Marrero, Louisiana, 70072, United States
Tandem Clinical Research - Metairie
Metairie, Louisiana, 70006, United States
Louisiana Research Center, LLC
Shreveport, Louisiana, 71105, United States
Mercy Medical Center, GI Research
Baltimore, Maryland, 21202, United States
Walter Reed Nat Mil Md Ctr
Bethesda, Maryland, 20889, United States
Woodholme Gastroenterology Associates
Glen Burnie, Maryland, 21061, United States
Boston Medical Center_Cary
Boston, Massachusetts, 02118, United States
University of Michigan Medicine
Ann Arbor, Michigan, 48109, United States
Henry Ford Health System
Detroit, Michigan, 48202, United States
Mayo Clinic
Rochester, Minnesota, 55905-0001, United States
Southern Therapy and Advanced Research LLC
Jackson, Mississippi, 39216, United States
Clinical Research Professionals
Chesterfield, Missouri, 63005, United States
Kansas City Research Institute
Kansas City, Missouri, 64131, United States
Univ of Nebraska Medical CTR
Omaha, Nebraska, 68198-3020, United States
Jubilee Clinical Research, Inc.
Las Vegas, Nevada, 89106, United States
Sierra Clinical Research-Las Vegas
Las Vegas, Nevada, 89106, United States
AIG Digestive Disease Research
Florham Park, New Jersey, 07932, United States
Premier Health Research, LLC
Sparta, New Jersey, 07871, United States
NYU Grossman School of Med
New York, New York, 10016, United States
Weill Cornell Med Coll-NYPH
New York, New York, 10021, United States
Icahn Sch of Med-Mt Sinai Hosp
New York, New York, 10029, United States
AtriumHealth Liver Care, Pineville
Charlotte, North Carolina, 28210, United States
Northeast GI Research Division
Concord, North Carolina, 28027, United States
Duke Univ. Med CNTR_Durham_2
Durham, North Carolina, 27710, United States
Ohio State Univ Wexner Med Ctr
Columbus, Ohio, 43210, United States
Objective GI
Springboro, Ohio, 45066, United States
CRIOH
Westlake, Ohio, 44145, United States
Options Health Research, LLC
Tulsa, Oklahoma, 74104, United States
Geisinger Clinic
Danville, Pennsylvania, 17822, United States
Pennsylvania State University
Hershey, Pennsylvania, 17033, United States
Univ of Pennsylvania Hospital
Philadelphia, Pennsylvania, 19104, United States
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, 19107-5244, United States
UPMC Center for Liver Diseases
Pittsburgh, Pennsylvania, 15213, United States
UPMC_Center for Liver Care
Pittsburgh, Pennsylvania, 15213, United States
Care Access Research, Pottsville
Pottsville, Pennsylvania, 17901, United States
Clinical Res Collaborative
Cumberland, Rhode Island, 02864, United States
Ocean St Clin Res Partnrs, LLC
Lincoln, Rhode Island, 02865, United States
Medical University Of South Carolina
Charleston, South Carolina, 29425, United States
WR-ClinSearch, LLC
Chattanooga, Tennessee, 37421, United States
Digestive Health Res-TSMC
Hermitage, Tennessee, 37076, United States
East Tennessee Research Institute
Johnson City, Tennessee, 37604, United States
Quality Medical Research
Nashville, Tennessee, 37211, United States
Amarillo Center for Clinical Research, Ltd.
Amarillo, Texas, 79106, United States
Texas Clin Res Inst, LLC
Arlington, Texas, 76012, United States
Liver Ins@ Mthdist DTX Med Cen
Dallas, Texas, 75203, United States
Velocity Clinical Res-Dallas
Dallas, Texas, 75230, United States
UT Southwestern Med Cntr
Dallas, Texas, 75390-9302, United States
South Texas Research Institute
Edinburg, Texas, 78539, United States
Brooke Army Medical Ctr.
Fort Sam Houston, Texas, 78234, United States
GI Alliance Research
Fort Worth, Texas, 76104, United States
Baylor College Of Medicine
Houston, Texas, 77030, United States
Houston Methodist Hospital
Houston, Texas, 77030, United States
Bipharma Informatic Inc.
Houston, Texas, 77043, United States
Bylr Coll Md-Ben Taub Gen Hos
Houston, Texas, 77054, United States
Houston Research Institute
Houston, Texas, 77079, United States
Biopharma Informatic
Houston, Texas, 77084, United States
Amir Ali Hassan, MD, PA
Houston, Texas, 77089, United States
Centex Studies - McAllen
McAllen, Texas, 78504, United States
LinQ Research, LLC
Pearland, Texas, 77584, United States
Amer. Rrsch Corp-TX Liver Inst
San Antonio, Texas, 78215, United States
Clinical Trials of Texas, LLC
San Antonio, Texas, 78229, United States
Mt Olympus Medical Research, LLC
Sugar Land, Texas, 77479, United States
Digestive Hlth Res of N Texas
Wichita Falls, Texas, 76301, United States
South Ogden Family Medicine/ CCT Research
Ogden, Utah, 84405, United States
Velocity Clinical Research, Riverton
Riverton, Utah, 84065, United States
University of Utah
Salt Lake City, Utah, 84132, United States
University Of Virginia Hospital
Charlottesville, Virginia, 22908, United States
Inova Fairfax Medical Campus
Falls Church, Virginia, 22042, United States
Digestive and Liver Disease Specialists
Norfolk, Virginia, 23502, United States
Bon Secours Richmond Community Hospital LLC
Richmond, Virginia, 23226, United States
McGuire VA Medical Center
Richmond, Virginia, 23249, United States
VCU Health System
Richmond, Virginia, 23298, United States
Gastroent Consult of SW VA
Roanoke, Virginia, 24014, United States
Centro de Investigaciones Metabólicas
Capital Federal, Buenos Aires, C1056ABI, Argentina
Hospital Britanico de Buenos Aires
Ciudad de Buenos Aires, Buenos Aires, 1280, Argentina
Hospital del Centenario
Rosario, Santa Fe, Santa Fe Province, S2002KDT, Argentina
DIM Clinica Privada
Buenos Aires, B1704ETD, Argentina
Centro Médico Viamonte SRL
CABA, C1120AAC, Argentina
Hospital Italiano Departamento Hepatologia
CABA, C1199ABH, Argentina
Glenny Corp. S.A
CABA, C1430CKE, Argentina
Centro de Investigaciones Metabólicas
Capital Federal, C1056ABJ, Argentina
Hospital El Cruce
Florencio Varela, Buenos Aires, 1888, Argentina
A.W. Morrow Gastroenterology and Liver Centre
Camperdown, New South Wales, 2050, Australia
Nepean Hospital
Kingswood, New South Wales, 2747, Australia
Liverpool Hospital
Liverpool, New South Wales, 2170, Australia
Westmead Hospital - Storr Liver Centre
Westmead, New South Wales, 2145, Australia
Westmead Hospital
Westmead, New South Wales, 2145, Australia
Griffith University Clinical Trial Unit
Southport, Queensland, 4222, Australia
Royal Adelaide Hospital - Hepatology Department
Adelaide, South Australia, 5000, Australia
Lyell McEwin Hospital
Elizabeth Vale, South Australia, 5112, Australia
St Vincent's Hospital Melbourne - Gastroenterology Department
Fitzroy, Victoria, 3065, Australia
Austin Hospital
Heidelberg, Victoria, 3084, Australia
Fiona Stanley Hospital - Hepatology
Murdoch, Western Australia, 6150, Australia
Sir Charles Gairdner Hospital - Hepatology Department
Nedlands, Western Australia, 6009, Australia
Klin.Abt. f. Gastroenterologie u. Hepatologie
Graz, 8036, Austria
Fließer-Görzer [Ordination]
Saint Stefan, 8511, Austria
LKH Salzburg Universitätsklinikum
Salzburg, 5020, Austria
Klinik Landstraße
Vienna, 1030, Austria
Klinikum Wels-Grieskirchen
Wels, 4600, Austria
CUB Hôpital Erasme_Brussels_0
Brussels, 1070, Belgium
Cliniques Universitaires Saint-Luc - Serv. Hépato-gastroentérology
Brussels, 1200, Belgium
UZA
Edegem, 2650, Belgium
Ziekenhuis Oost-Limburg AV - Gastro
Genk, 3600, Belgium
AZ Maria Middelares - Gent - Gastro-Enterology
Ghent, 9000, Belgium
UZ Gent - Department Gastro-enterology
Ghent, 9000, Belgium
Fundação Bahiana de Infectologia
Salvador, Estado de Bahia, 40110160, Brazil
Hospital das Clínicas da Universidade Federal de Goiás
Goiânia, Goiás, 74605-020, Brazil
Hospital de Clínicas de Porto Alegre_Porto Alegre
Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
Fundação Pio XII
Barretos, São Paulo, 14780-070, Brazil
Fundação Pio XII - Hospital de Amor de Barretos
Barretos, São Paulo, 14784-400, Brazil
UPECLIN- Unidade de Pesquisa Clínica da Faculdade de Medicina de Botucatu
Botucatu, São Paulo, 18618-686, Brazil
CIP Centro Integrado de Pesquisas do Hospital de Base
São José do Rio Preto, São Paulo, 15090-000, Brazil
Assoc. Paulista para o Desenvolvimento da Medicina - UNIFESP
São Paulo, São Paulo, 04024-002, Brazil
Departamento de Gastroenterologia - HCFMUSP
São Paulo, São Paulo, 05403-000, Brazil
Hospital Universitario Clementino Fraga Filho
Rio de Janeiro, 21941-617, Brazil
Rocco e Nazato Servicos Medicos LTDA
São Paulo, 04543-011, Brazil
MHAT - UniHospital OOD
Panagyurishte, 4500, Bulgaria
MHAT Med Line Clinic
Plovdiv, 4000, Bulgaria
"Acibadem City Clinic UMHAT Tokuda"
Sofia, 1407, Bulgaria
Acibadem City Clinic UMHAT Tokuda EAD, Gastroenterology
Sofia, 1407, Bulgaria
DCC Aleksandrovska EOOD
Sofia, 1431, Bulgaria
UMHAT Sveti Ivan Rilski EAD, Gastroenterology
Sofia, 1431, Bulgaria
Medical Center Vertebra OOD
Sofia, 1504, Bulgaria
"UMHAT "Tsaritsa Yoanna-ISUL"" EAD, Gastroenterology clinic
Sofia, 1527, Bulgaria
UMHAT Tsaritsa Yoanna - ISUL EAD, Gastroenterology
Sofia, 1527, Bulgaria
"DCC XX - Sofia" EOOD
Sofia, 1618, Bulgaria
DCC XX - Sofia EOOD, Gastroenterology
Sofia, 1618, Bulgaria
"UMHAT "Sveta Anna" Sofia" AD
Sofia, 1750, Bulgaria
Acibadem City Clinic UMHAT EOOD, Gastroenterology
Sofia, 1784, Bulgaria
Medical Center Synexus Sofia EOOD
Sofia, 1784, Bulgaria
UMHAT Sveta Marina EAD, Clinic of Gastroenterology
Varna, 9010, Bulgaria
University of Calgary Liver Unit-(HMRC)
Calgary, Alberta, T2N 4Z6, Canada
GI Research Inst Foundation
Vancouver, British Columbia, V6Z 2K5, Canada
Nova Scotia Hlth Halifax
Halifax, Nova Scotia, B3H 2Y9, Canada
LMC ClinRsrh Inc.Brampton
Brampton, Ontario, L6S 0C6, Canada
London Hlth Sci Ctr- Univ Camp
London, Ontario, N6A 5A5, Canada
Centricity Research LMC (Toronto)
Toronto, Ontario, M4G 3E8, Canada
Toronto Liver Centre
Toronto, Ontario, M6H 3M1, Canada
TDDA Specialty Research
Vaughan, Ontario, L4L 4Y7, Canada
Ecogene-21
Chicoutimi, Quebec, G7H 7K9, Canada
McGill University Health Centre
Montreal, Quebec, H4A 3J1, Canada
Clinique Medicine Urbaine du Quartier Latin, Inc.
Montreal, Quebec, QC H2L 4E9, Canada
Hospital Fleurimont / CIUSS
Sherbrooke, Quebec, J1H 5N4, Canada
Ctr de Med Metab de Lanaudiere
Terrebonne, Quebec, J6X 4P7, Canada
Beijing Ditan Hospital Capital Medical University-Hepatology
Beijing, Beijing Municipality, 100015, China
Peking University People's Hospital-(White Pagoda Temple Area) - Hepatopathy
Beijing, Beijing Municipality, 100034, China
Beijing Friendship Hospital, Capital Medical University-Endocrinology
Beijing, Beijing Municipality, 100050, China
Beijing You'an Hospital, Capital Medical University-Hepatology center
Beijing, Beijing Municipality, 100069, China
Beijing Tsinghua Changgung Hospital-Hepatology
Beijing, Beijing Municipality, 102218, China
Chongqing University Three Gorges Hospital-Hepatology
Chongqing, Chongqing Municipality, 404140, China
The First People's Hospital of Foshan-Infectious Disease
Foshan, Guangdong, 528000, China
Guangzhou Eighth People's Hospital, Guangzhou Medical University-Hepatology
Guangzhou, Guangdong, 510060, China
The First Affiliated Hospital, Sun Yat-sen University
Guangzhou, Guangdong, 510080, China
Guangzhou First People's Hospital-Gastroenterology
Guangzhou, Guangdong, 510180, China
Nanfang Hospital, Southern Medical University-Infectious Diseases
Guangzhou, Guangdong, 510515, China
The Third Affiliated Hospital, Sun Yat-sen University-Infectious
Guangzhou, Guangdong, 510650, China
Peking University Shenzhen Hospital
Shenzhen, Guangdong, 518036, China
The Third People's Hospital of Shenzhen-Hepatology
Shenzhen, Guangdong, 518112, China
The Third Hospital of Hebei Medical University-Hepatology
Shijiazhuang, Hebei, 050051, China
Hunan Provincial People's Hospital-Hepatology
Changsha, Hunan, 410005, China
Hunan Provincial People's Hospital
Changsha, Hunan, 410005, China
Changzhou No.2 People's Hospital
Changzhou, Jiangsu, 213003, China
The Second Affiliated Hospital of Nanjing Medical University-Hepatology
Nanjing, Jiangsu, 210003, China
The Affiliated Hospital of Xuzhou Medical University (East) - Infectious Diseases
Xuzhou, Jiangsu, 221011, China
The Third People's Hospital of Zhenjiang-Hepatology
Zhenjiang, Jiangsu, 212021, China
The First Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, 330006, China
The First Bethune Hospital of Jilin University-Hepatic Biliary Pancreatic Medicine
Changchun, Jilin, 130021, China
General Hosp of Ningxia Medical University,Infectious Depart
Yinchuan, Ningxia, 750004, China
Jinan Central Hospital
Jinan, Shandong, 250013, China
Liaocheng People's Hospital-Infectious Diseases
Liaocheng, Shandong, 252000, China
Liaocheng People's Hospital
Liaocheng, Shandong, 252000, China
Qingdao Municipal Hospital (Group)-Infectious Diseases
Qingdao, Shandong, 266011, China
Shanghai Jiao Tong University School of Medicine Renji Hospital-Gastroenterology
Shanghai, Shanghai Municipality, 200001, China
Ruijin Hospital Affiliate to The Shanghai Jiaotong University-Infectious Diseases
Shanghai, Shanghai Municipality, 200025, China
Ruijin Hospital Affiliate to The Shanghai Jiaotong Universit
Shanghai, Shanghai Municipality, 200025, China
Shanghai Ninth People's Hospital-Infection Disease
Shanghai, Shanghai Municipality, 201999, China
Shanghai Ninth People's Hospital
Shanghai, Shanghai Municipality, 201999, China
West China Hospital Sichuan University-Infectious Diseases
Chengdu, Sichuan, 610044, China
Tianjin Third Central Hospital-Gastroenterology
Tianjin, Tianjin Municipality, 300170, China
Tianjin Second People's Hospital-Liver Disease Department III
Tianjin, Tianjin Municipality, 300211, China
Zhejiang Hospital-Infectious Diseases
Hangzhou, Zhejiang, 310030, China
The First Affiliated Hospital of WMU
Wenzhou, Zhejiang, 325000, China
Zhejiang Hospital-Infectious Diseases
Hangzhou, 310030, China
The Third People's Hospital of Shenzhen
Shenzhen, 518112, China
Tianjin Second People's Hospital-Liver Disease Department III
Tianjin, 300211, China
Klinicki bolnicki centar Osijek_Endocrinology
Osijek, 31 000, Croatia
Klinicki bolnicki centar Osijek
Osijek, 31 000, Croatia
KBC Rijeka, Zavod za gastroenterologiju
Rijeka, 51000, Croatia
KBC Split/ Firule/ Gastroenterologija
Split, 21000, Croatia
KBC Split_Gastroenterology
Split, 21000, Croatia
KB Dubrava, Zavod za gastroenterologiju
Zagreb, 10000, Croatia
Klinički bolnički centar Zagreb, Zavod za gastroenterologiju
Zagreb, 10000, Croatia
Krajská nemocice Liberec, a.s
Liberec, 460 01, Czechia
Researchsite s.r.o.
Pilsen, 301 00, Czechia
Vseobecna Fakultni nemocnice v Praze
Prague, 128 08, Czechia
Aarhus Universitetshospital Skejby Mave-Tarm
Aarhus N, 8200, Denmark
Hvidovre Hospital - Gastroenheden
Hvidovre, 2650, Denmark
Bispebjerg Hospital - Abdominal Center K, Research Unit
København NV, 2400, Denmark
Odense University Hospital - FLASH - Centre for Liver Research
Odense C, 5000, Denmark
Centre Hospitalier Universitaire D'Angers-1
Angers, 49100, France
Centre Hospitalier Universitaire D'Angers
Angers, 49100, France
Ap-Hp-Hopital Beaujon
Clichy, 92110, France
Centre Hospitalier Universitaire de Lille-Hopital Claude Huriez
Lille, 59000, France
Hospices Civils de Lyon-Hopital de La Croix Rousse
Lyon, 69317, France
Centre Hospitalier Universitaire de Nice-Hopital de L'Archet
Nice, 06200, France
APHP-HOPITAL LA PITIE SALPETRIERE_Service Hépato-Gastro-Enterologie
Paris, 75013, France
Ap-Hp-Hopital Cochin
Paris, 75014, France
Centre Hospitalier Universitaire de Bordeaux-Hopital Haut Leveque
Pessac, 33600, France
Hospices Civils de Lyon-Hopital Lyon Sud
Pierre-Bénite, 69310, France
Les Hopitaux Universitaires de Strasbourg-Hopital Civil
Strasbourg, 67091, France
Gastro am Bayerischen Platz - Hofmann W.-P.n
Berlin, 10825, Germany
Charité - Campus Virchow-Klinikum - Med. Klinik für Hepatologie und Gastroenterologie
Berlin, 13353, Germany
Uniklinik Knappschaftskrankenhaus Bochum GmbH - Med. Klinik - Gastroenterologie & Hepatologie
Bochum, 44892, Germany
Universitätsklinikum Bonn - Med. Klinik und Poliklinik I
Bonn, 53127, Germany
Uniklinik FFM - Hepatologie
Frankfurt, 60590, Germany
Medizinische Hochschule Hannover - Gastroentero-, Hepato-, Endokrinologie
Hanover, 30625, Germany
Prof. Dr. Schiefke Ingolf, EUGASTRO GmbH
Leipzig, 04103, Germany
Universitätsklinikum Leipzig - Klinik und Poliklinik für Onkologie, Gastroenterologie, Hepatologie und Pneumologie
Leipzig, 04103, Germany
Uniklinik Schleswig-Holstein - Medizinischen Klinik I am Campus Lübeck
Lübeck, 23538, Germany
Uniklinik Otto Von Guericke Magdeburg - Gastroenterologie, Hepatologie and Infektiologie
Magdeburg, 39120, Germany
Universitätsmedizin der JGU Mainz - Hepatologie
Mainz, 55131, Germany
Universitätsmedizin Mannheim - II. Medizinische Klinik
Mannheim, 68167, Germany
Universitätsklinikum Würzburg - Zentrum für Innere Medizin (ZIM)
Würzburg, 97080, Germany
Gen Hospital of Athens Ippokrateio,B' Uni Clinic of Inte Med
Athens, 11527, Greece
Gen Hospital of Athens Laiko,1st Dpt. of Propaedeutic Inter
Athens, 11527, Greece
General Hospital of Athens "LAIKO"
Goudi, Athens, 115 27, Greece
Univ Gen Hospital of Ioannina,Gastroenterology-Endoscopy Uni
Ioannina, 45500, Greece
Univ Gen Hospital Larisa, Cardiology Medicine Clinic
Larissa, 41110, Greece
"AHEPA" University Hospital of Thessaloniki
Thessaloniki, 54621, Greece
AHEPA General University Hospital
Thessaloniki, 54636, Greece
General Hospital of Thessaloniki "Ippokrateio"
Thessaloniki, 54642, Greece
Yashoda Hospital
Secunderabad, Andhra Pradesh, 500003, India
Surat Institute of Digestive Science
Surat, Gujarat, 395002, India
BAPS Pramukh Swami Hospital
Surat, Gujarat, 395009, India
Medanta - The Medicity Multi-Speciality Hospital, Gurugram
Gurgaon, Haryana, 122001, India
Kasturba Medical College Hospitals (KMC Hospitals), Mangalore
Mangalore, Karnataka, 575001, India
Gleneagles Hospital, Super-speciality and Transplant Centre, Parel
Mumbai, Maharashtra, 400012, India
Seth GS medical college and KEM Hospital
Mumbai, Maharashtra, 400012, India
Midas Multispeciality Hospital
Nagpur, Maharashtra, 441108, India
All India Institute of medical Sciences
Delhi, New Delhi, 110029, India
Institute of liver and Biliary Sciences
Ghitorni, New Delhi, 110070, India
Post Graduate Institute of Medical Education & Research_Chandigarh
Chandigarh, Punjab, 160012, India
Dayanand Medical College & Hospital
Ludhiana, Punjab, 141001, India
Fortis Heart Institute and Multispeciality Hospital
Mohali, Punjab, 160062, India
S.R.Kalla Memorial Gastro & General Hospital
Jaipur, Rajasthan, 302001, India
SMS Super speciality Hospital, Department of Gastroenterology
Jaipur, Rajasthan, 302004, India
Osmania General Hospital_Hyderabad
Hyderabad, Telangana, 500012, India
Dr P V Rao - Diabetes Research Centre
Hyderabad, Telangana, 50082, India
MV Hospital and Research Centre
Lucknow, Uttar Pradesh, 226003, India
Fortis Escort Heart Institute
New Delhi, 110025, India
Hepatology St James's
Dublin, D08 NHY1, Ireland
Beaumont Hospital Hepatology Dept
Dublin, D09V2N0, Ireland
Carmel MC - Liver Unit
Haifa, 3434104, Israel
Carmel Medical Center Liver Unit
Haifa, 3434104, Israel
Shaare Zedek MC - Liver Unit
Jerusalem, 91031, Israel
Shaare Zedek Medical Center
Jerusalem, 91031, Israel
Hadassah Ein Karam MC - Liver Unit
Jerusalem, 91120, Israel
Western Galilee MC - Internal Medicine A
Nahariya, 2210001, Israel
Liver Institute, Rabin Medical Center, Beilinson Campuse
Petah Tikva, 49100, Israel
Rabin MC Beilinson - Liver Institute
Petah Tikva, 49100, Israel
Sheba MC - Liver Diseases Center
Ramat Gan, 52621, Israel
Sourasky MC - Liver Unit
Tel Aviv, 64239, Israel
Azienda Ospedaliero-Universitaria Renato Dulbecco
Catanzaro, Cz, 88100, Italy
IRCCS Casa Sollievo della Sofferenza San Giovanni Rotondo
San Giovanni Rotondo, Foggia, 71013, Italy
AOUP Giaccone Palermo
Palermo, Sicily, 90127, Italy
Azieda Ospedaliero-Universitaria, Policlinico S. Orsola-Malp
Bologna, 40138, Italy
AOU Careggi Padiglione 16 San Luca, 3° piano
Florence, 50134, Italy
Azienda Ospedaliero Universitaria Ospedali Riuniti - Foggia
Foggia, 71122, Italy
Osp Magg Policlinico Centro Malattie metaboliche del Fegato
Milan, 20122, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCS
Roma, 00168, Italy
Policlinico Università Campus Biomedico di Roma
Rome, 00128, Italy
Città della salute e della scienza - university of Torino
Torino, 10126, Italy
Juntendo University Hospital, Gastroenterology
Bunkyo-ku, Tokyo, 113-8431, Japan
Juntendo University Hospital_Gastroenterology
Bunkyo-ku, Tokyo, 113-8431, Japan
The University of Tokyo Hospital, Gastroenterology
Bunkyo-ku, Tokyo, 113-8655, Japan
Fukui-ken Saiseikai Hospital, Internal Medicine
Fukui-shi, Fukui, 918-8503, Japan
Fukui-ken Saiseikai Hospital_Internal Medicine
Fukui-shi, Fukui, 918-8503, Japan
Hoshi General Hospital_Gastroenterology
Fukushima, 963-8801, Japan
Gifu Municipal Hospital_Hepatology
Gifu, 500-8513, Japan
Ogaki Municipal Hospital_Gastroenterology and Hepatology
Gifu, 503-8502, Japan
Hamamatsu University Hospital_Liver Internal Medicine
Hamamatsu-shi, Shizuoka, 431-3192, Japan
JA Hiroshima General Hospital_Gastroenterology and Hepatology
Hatsukaichi-shi, Hiroshima, 783-8503, Japan
Hiroshima Red Cross & Atomic-b_Hepatology
Hiroshima-shi, Hiroshima, 730-8619, Japan
Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hosp.
Hiroshima-shi, Hiroshima, 730-8619, Japan
Hiroshima University Hospital_Department of Gastro.&Metabo.
Hiroshima-shi, Hiroshima, 734-8551, Japan
Hiroshima University Hospital
Hiroshima-shi, Hiroshima, 734-8551, Japan
Juntendo University Shizuoka Hospital_Gastroenterology & Hepatology
Izunokuni-shi, Shizuoka, 410-2295, Japan
Juntendo University Shizuoka Hospital
Izunokuni-shi, Shizuoka, 410-2295, Japan
Kagoshima University Hospital, Gastroenterology
Kagoshima-shi, Kagoshima, 890-8520, Japan
Kagoshima University Hospital_Gastroenterology
Kagoshima-shi, Kagoshima, 890-8520, Japan
University Hospital Kyoto Prefectual University of Medicine
Kamigyo-ku, Kyoto, 602-8566, Japan
Kanazawa University Hospital_Gastroenterology
Kanazawa-shi, Ishikawa, 920-8641, Japan
Kanazawa University Hospital
Kanazawa-shi, Ishikawa, 920-8641, Japan
Nara Medical University Hospital_Department of Gastro.& Metabo.
Kashihara-shi, Nara, 634-8522, Japan
Nara Medical University Hospital_Kashihara-shi, Nara
Kashihara-shi, Nara, 634-8522, Japan
St. Marianna University School of Medicine Hospital
Kawasaki-shi, Kanagawa, 216-8511, Japan
Kumamoto Shinto General Hospital_Liver・Gastroenterology
Kumamoto-shi, Kumamoto, 862-8655, Japan
Toranomon Hospital, Hepatology
Minato-ku, Tokyo, 105-8470, Japan
Japanese Red Cross Musashino Hospital_Gastroenterology
Musashino-shi, Tokyo, 180-8610, Japan
Japanese Red Cross Musashino Hospital
Musashino-shi, Tokyo, 180-8610, Japan
Aichi Medical University Hospital_Hepatology and pancreology
Nagakute-shi, Aichi, 480-1195, Japan
Aichi Medical University Hospital
Nagakute-shi, Aichi, 480-1195, Japan
Heartlife Hospital_Liver internal medicine
Nakagamigun, Okinawa, 901-2492, Japan
Nara City Hospital, Gastroenterology and Hepatology
Nara-shi, Nara, 630-8305, Japan
Hyogo Medical University Hospital_Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine
Nishinomiya-shi, Hyogo, 663-8501, Japan
Oita Cardiovascular Hospital_Gastroenterology
Oita-shi, Oita, 870-0837, Japan
Kawasaki Medical School General Medical Center_Internal Medicine
Okayama-shi, Okayama, 700-8505, Japan
Kawasaki Medical School General Medical Center
Okayama-shi, Okayama, 700-8505, Japan
Japan Organization of Occupational Health and Safety Osaka Rosai Hospital_Gastroenterology
Osaka, 591-8025, Japan
Osaka Metropolitan University Hospital, Department of Hepatology
Osaka-shi, Osaka, 545-8586, Japan
Osaka Metropolitan University Hospital_Department of Hepatology
Osaka-shi, Osaka, 545-8586, Japan
Otsu City Hospital, Gastroenterological Medicine
Otsu-shi, Shiga, 520-0804, Japan
Saga University Hospital_Liver Center
Saga-shi, Saga, 849-8501, Japan
Japan Community Health care Organization Hokkaido Hospital
Sapporo-shi, Hokkaido, 062-8618, Japan
JCHO Hokkaido Hospital_Digestive Disease Center
Sapporo-shi, Hokkaido, 062-8618, Japan
Sendai Kousei Hospital_Liver Internal Medicine
Sendai-shi, Miyagi, 981-0914, Japan
Sendai Kousei Hospital
Sendai-shi, Miyagi, 981-0914, Japan
Tokyo Women's Medical University Hospital
Shinjuku-ku, Tokyo, 162-8666, Japan
Saiseikai Suita Hospital, Gastroenterology
Suita-shi, Osaka, 564-0013, Japan
Osaka University Hospital_Department of Gastro. & Hepato
Suita-shi, Osaka, 565-0871, Japan
Kagawa Prefectural Central Hospital_Liver internal medicine
Takamatsu-shi, Kagawa, 760-8557, Japan
Kagawa Prefectural Central Hospital
Takamatsu-shi, Kagawa, 760-8557, Japan
National Hospital Organization Takasaki General Medical Ctr._Gastroenterology
Takasaki-shi, Gunma, 370-0829, Japan
Nihon University Itabashi Hospital_Division of Gastro.&Hepa.
Tokyo, 173-8610, Japan
Nihon University Itabashi Hospital
Tokyo, 173-8610, Japan
Ehime University Hospital_Department of Gastro.& Metabo.
Toon-shi, Ehime, 791-0295, Japan
Ehime University Hospital
Toon-shi, Ehime, 791-0295, Japan
Saiseikai Wakayama Hospital_Gastroenterology
Wakayama-shi, Wakayama, 640-8158, Japan
Saiseikai Wakayama Hospital
Wakayama-shi, Wakayama, 640-8158, Japan
Yokohama City University Hospital_Gastrointestinal Medicine
Yokohama-shi, Kanagawa, 236-0004, Japan
Hospital Universiti Sains Malaysia
Kota Bharu, Kelantan, 16150, Malaysia
University Malaya Medical Centre
Kuala Lumpur, Kuala Lumpur, 59100, Malaysia
University Malaya Medical Centre
Lembah Pantai, Kuala Lumpur, 59100, Malaysia
Hospital Selayang
Batu Caves, 68100, Malaysia
Centro de Investigacion Clinica del Pacifico, S.A. de C.V.
Acapulco de Juárez, Guerrero, 39670, Mexico
Centro de Investigación Médico Biológica y Terapia
Guadalajara, Jalisco, 44130, Mexico
Centro de Investigación y Gastroenterología, S.C.
Mexico City, México, D.F., 06700, Mexico
Investigaciones Médicas Cisneros, S.C.
Monterrey, Nuevo León, 64000, Mexico
Servicios de Oncologia Medica Integral S.A de C.V (ONCARE)
San Pedro Garza García, Nuevo León, 66220, Mexico
Hospital Angeles de Culiacan
Culiacán, Sinaloa, 80020, Mexico
Medical Care and Research S. A de C.V
Mérida, Yucatán, 97070, Mexico
Centro de Investigación y Gastroenterología_ Hospital Angeles Universidad
México, 03330, Mexico
Noordwest Ziekenhuisgroep
Alkmaar, 1815 JD, Netherlands
AmsterdamUMC AMC
Amsterdam, 1105 AZ, Netherlands
Leids Universitair Medisch Centrum
Leiden, 2333 ZA, Netherlands
Franciscus Gasthuis en Vlietland
Rotterdam, 3045 PM, Netherlands
Bærum sykehus - Vestre Viken HF
Gjettum, 1346, Norway
Bærum sykehus
Gjettum, 1346, Norway
Oslo universitetssykehus, Ullevål
Oslo, 0450, Norway
ID Clinic Arkadiusz Pisula
Myslowice, Lesser Poland Voivodeship, 41-400, Poland
Gizinscy Centrum Medyczne
Bydgoszcz, 85-676, Poland
BodyClinic
Warsaw, 03-712, Poland
Centrum Badan Klinicznych
Wroclaw, 51-162, Poland
FutureMeds Sp. z o.o.
Wroclaw, 53-673, Poland
Ko-Med Centra Kliniczne Staszow
Staszów, Świętokrzyskie Voivodeship, 28-200, Poland
Velocity Nova Sp. z o.o.
Staszów, Świętokrzyskie Voivodeship, 28-200, Poland
ULS De Matosinhos E.P.E.- Hospital Pedro Hispano
Senhora Da Hora, Matosinhos, Matosinhos, 4464-513, Portugal
Hospital Garcia de Orta
Almada, 2805-267, Portugal
ULS De Almada-Seixal E.P.E. - Hospital Garcia de Orta
Almada, 2805-267, Portugal
ULS Da Regiao De Aveiro E.P.E. - Hospital Infante D. Pedro
Aveiro, 3814-501, Portugal
ULS De Braga, E.P.E. - Hospital de Braga
Braga, 4710-243, Portugal
ULS Da Guarda E.P.E. - Hospital Sousa Martins
Guarda, 6301-858, Portugal
ULS Do Alto Ave, E.P.E. - Hospital Senhora da Oliveira - Guimarães
Guimarães, 4835-044, Portugal
APDP - Associação Protectora dos Diabéticos de Portugal
Lisbon, 1250-189, Portugal
Unidade Local De Saúde De Santa Maria E.P.E.
Lisbon, 1649-035, Portugal
ULS De Santo António, E.P.E. - Hospital de Santo António
Porto, 4099-001, Portugal
ULS De São João, E.P.E. - Hospital de São João
Porto, 4200-319, Portugal
ULS Do Alto Minho E.P.E. - Hospital de Santa Luzia
Viana do Castelo, 4904-858, Portugal
Hospital da Luz Arrabida, S.A.
Vila Nova de Gaia, 4400-346, Portugal
ULS De Gaia/Espinho E.P.E. - Hospital Eduardo Santos Silva
Vila Nova de Gaia, 4434-502, Portugal
ULS De Tras-Os-Montes E Alto Douro E.P.E. - Unidade Hospitalar de Vila Real
Vila Real, 5000-508, Portugal
FDI Clinical Research
San Juan, 00927, Puerto Rico
Sana Monitoring SRL
Bucharest, 011025, Romania
Hightech Medical Services S.R.L.
Bucharest, 011053, Romania
Institutul Clinic Fundeni
Bucharest, 022328, Romania
Spitalul Universitar de Urgenta Bucuresti
Bucharest, 050098, Romania
Spitalul Clinic CF Cluj Napoca
Cluj-Napoca, 400015, Romania
Institutul Gastroenterologie-Hepatologie Cluj-Napoca
Cluj-Napoca, 400162, Romania
Gastroenterologie Spitalul Judetean Constanta
Constanța, 900591, Romania
SC Diamed Obesity SRL
Galati, 800291, Romania
Gastromedica
Iași, 700506, Romania
Spital Judetean De Urgenta Satu Mare
Satu Mare, 440055, Romania
Volosevich First City Clinical Hospital
Arkhangelsk, 163001, Russia
City Hospital #5
Barnaul, 656045, Russia
Kazan Federal University
Kazan', 420097, Russia
LLC "Clinic of Aesthetic Medicine & Laser Technologies"
Kazan', 420111, Russia
Friendship University of Russia
Moscow, 117292, Russia
Setchenov First Moscow State Medical University
Moscow, 119435, Russia
PHI "Central Clinical Hospital RZD- Medicine"
Moscow, 125367, Russia
Limited Law Company "Healthy Family" Medicine Center"
Novosibirsk, 630099, Russia
Penza Regional Clinical Hospital named after N.N. Burdenko
Penza, 440026, Russia
Joint Stock Company "Polyclinic Complex"
Saint Petersburg, 190013, Russia
SPb SBHI City Outpatient clinic #109
Saint Petersburg, 192283, Russia
Limited Liability Company "Energiya Zdoroviya"
Saint Petersburg, 194156, Russia
North-Western State Medical Univer. based on Med-Prof Center
Saint Petersburg, 195067, Russia
Consultative & Diagnostic Center with a Outpatient Hospital
Saint Petersburg, 197110, Russia
Siberian State Medical University
Tomsk, 634050, Russia
Ulianovsk Regional Clinical Hospital
Ulyanovsk, 432063, Russia
Polyclinic #2 in Yoshkar-Ola
Yoshkar-Ola, 424004, Russia
Clin. Centre Vojvodina, Clin. endocr., diab. and met. dis.
Novi Sad, Vojvodina, 21000, Serbia
Clinic for gastroenterology and hepatology
Belgrade, 11000, Serbia
Endocrinology, Diabetes and Metabolism Diseases Clinic
Belgrade, 11000, Serbia
Clinical-hospital centre Zvezdara
Belgrade, 11020, Serbia
National University Hospital Singapore_Tahir Building
Singapore, 119228, Singapore
National University Hospital_Tahir Building
Singapore, 119228, Singapore
Singapore General Hospital
Singapore, 169608, Singapore
Changi General Hospital
Singapore, 529889, Singapore
Changi General Hospital
Singapore, 529905, Singapore
Nemocnica akademika L. Derera, UNB
Bratislava, 833 05, Slovakia
MEDISPEKTRUM s.r.o.
Bratislava, 851 01, Slovakia
II. Interna klinika, Univerzitna nemocnica L. Pasteura Kosice
Košice, 040 11, Slovakia
Hepatobiliarne centrum - Michalovce
Michalovce, 071 01, Slovakia
JAL s.r.o.
Trnava, 91701, Slovakia
Phoenix Pharma
Port Elizabeth, Eastern Cape, 6001, South Africa
Chris Hani Baragwanath Hospital
Johannesburg, Gauteng, 2013, South Africa
WITS Clinical Research
Johannesburg, Gauteng, 2193, South Africa
Lenasia Clinical Trial Centre
Lenasia, Gauteng, 1827, South Africa
Maxwell Centre
Durban, KwaZulu-Natal, 4001, South Africa
Lenmed Shifa Private Hospital
Durban, KwaZulu-Natal, 4901, South Africa
Tiervlei Trial Centre
Cape Town, Western Cape, 7530, South Africa
Dr Rajabally's Practice
Cape Town, Western Cape, 7800, South Africa
Wits Health Consortium
Johannesburg, 2193, South Africa
Kyungpook National University Hospital
Daegu, 41944, South Korea
Yeungnam Univ. Medical Center
Daegu, 42415, South Korea
Keimyung University Dongsan Hospital
Daegu, 42601, South Korea
Wonju Severance Christian Hospital
Gangwon-do, 26426, South Korea
Soon Chun Hyang University Hospital Bucheon
Gyeonggi-do, 14584, South Korea
Severance Hospital, Yonsei University Health System
Seoul, 03722, South Korea
Chung-Ang University Hospital
Seoul, 06973, South Korea
SMG-SNU Boramae Medical Center
Seoul, 07061, South Korea
Korea University Guro Hospital
Seoul, 08308, South Korea
Complejo Hospitalario de Pontevedra - Hospital de Montecelo
Pontevedra, Galicia, 36004, Spain
Hospital Vall d'Hebron
Barcelona, 08035, Spain
Hospital Universitario Puerta de Hierro Majadahonda
Majadahonda, 28222, Spain
Complejo Hospitalario de Pontevedra - Hospital de Montecelo
Pontevedra, 36004, Spain
Hospital Universitario Marqués de Valdecilla
Santander, 39008, Spain
Hospital Universitario Virgen del Rocío
Seville, 41013, Spain
Hospital General de Valencia
Valencia, 46014, Spain
Hospital Universitario y Politécnico La Fe
Valencia, 46026, Spain
Hospital Clínico de Valladolid
Valladolid, 47010, Spain
Universitätsklinik für Viszerale Chirurgie und Medizin
Bern, 3010, Switzerland
Hôpitaux Universitaires de Genève
Geneva, 1211, Switzerland
Kantonsspital Olten
Olten, 4600, Switzerland
Kantonsspital St. Gallen
Sankt Gallen, 9007, Switzerland
USZ Klinik für Gastroenterologie und Hepatologie
Zurich, 8091, Switzerland
Ditmanson Medical Foundation Chia-Yi Christian Hospital
Chiayi City, 600, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, 807, Taiwan
Taipei Tzu Chi Hospital
New Taipei City, 231, Taiwan
China Medical University Hospital
Taichung, 404, Taiwan
National Cheng Kung University Hospital
Tainan, 704, Taiwan
National Taiwan University Hospital_main
Taipei, 100, Taiwan
Taipei Mackay Memorial Hospital
Taipei, 104, Taiwan
Cathay General Hospital
Taipei, 106, Taiwan
Taipei Medical University Hospital
Taipei, 110, Taiwan
Taipei-Veterans General Hospital - Dept of Gastrointestinal
Taipei, 112, Taiwan
T.C. Saglık Bakanlıgı Adana Sehir Egitim ve Arastirma Hastan
Adana, 01000, Turkey (Türkiye)
Hacettepe Universitesi Tıp Fakültesi- Gastroenteroloji
Ankara, 06230, Turkey (Türkiye)
Ankara Universitesi Tıp Fakultesi Gastroenteroloji Bilim Da
Ankara, 06590, Turkey (Türkiye)
Ankara Üniversitesi Tıp Fakültesi Cebeci Araştırma Ve Uygulama Hastanesi-Gastroenteroloji
Ankara, 06590, Turkey (Türkiye)
Ankara Bilkent Şehir Hastanesi-Gastroenteroloji
Ankara, 06800, Turkey (Türkiye)
Ankara Sehir Hastanesi,Gastroenteroloji Klinigi
Ankara, 06800, Turkey (Türkiye)
Bursa Uludağ Üniversitesi Hastanesi-Gastroenteroloji
Bursa, 16059, Turkey (Türkiye)
Uludag Universitesi Tıp Fakultesi-Gastroenteroloji
Bursa, 16059, Turkey (Türkiye)
Koc Universitesi Hastanesi-Gastroenteroloji
Istanbul, 34010, Turkey (Türkiye)
Bezmialem Vakıf Üniversitesi Hastanesi-Gastroenteroloji
Istanbul, 34093, Turkey (Türkiye)
Istanbul Universitesi Istanbul Tip Fakultesi-Gastroenterolog
Istanbul, 34093, Turkey (Türkiye)
Umraniye Egitim ve Arastirma Hastanesi, Gastroenteroloji
Istanbul, 34764, Turkey (Türkiye)
Marmara Üniversitesi Pendik EAH- Gastroenteroloji
Istanbul, 34899, Turkey (Türkiye)
Ege Universitesi Tip Fakultesi Hastanesi, Gastroenteroloji
Izmir, 35100, Turkey (Türkiye)
Kocaeli Üniversitesi Hastanesi - Gastroenteroloji
Kocaeli, 41000, Turkey (Türkiye)
Mersin Universitesi Tip Fakultesi Gastroenteroloji Bilim Dal
Mersin, 33343, Turkey (Türkiye)
Mersin Üniversitesi Tip Fakültesi Hastanesi -Gastroenteroloji
Mersin, 33343, Turkey (Türkiye)
Adana Şehir Eğitim ve Araştırma Hastanesi-Endokrinoloji
Yüreğir/Adana, 1370, Turkey (Türkiye)
Royal Victoria Hospital
Belfast, BT12 6BA, United Kingdom
Queen Elizabeth Hospital, Birmingham
Birmingham, B15 2TH, United Kingdom
University Hospital Coventry - WISDEM Centre
Coventry, CV2 2DX, United Kingdom
Royal Derby Hospital
Derby, DE22 3DT, United Kingdom
Royal Derby Hospital
Derby, DE22 3NE, United Kingdom
Ninewells Hospital
Dundee, DD1 9SY, United Kingdom
Royal Devon and Exeter Hospital
Exeter, EX2 5DW, United Kingdom
Hull Royal Infirmary_Hull
Hull, HU3 2GZ, United Kingdom
Hull Royal Infirmary
Hull, HU3 2GZ, United Kingdom
Ipswich Hospital - Diabetes
Ipswich, IP4 5RH, United Kingdom
The Diabetes Centre
Ipswich, IP4 5RH, United Kingdom
St James's University Hospital
Leeds, LS9 7TF, United Kingdom
St. James University Hospital
Leeds, LS9 7TF, United Kingdom
The Royal London Hospital - Grahame Hayton Unit
London, E1 1FR, United Kingdom
Royal Free Hospital - Immunity & Transplantation
London, NW3 2QG, United Kingdom
Institute of Liver Studies
London, SE5 9RS, United Kingdom
Chelsea & Westminster Hospital
London, SW10 9NH, United Kingdom
Imperial College London
London, W2 1NY, United Kingdom
Freeman Hospital, Newcastle
Newcastle upon Tyne, NE7 7DN, United Kingdom
Nottingham University Hospitals NHS Trust
Nottingham, NG7 2UH, United Kingdom
Nottingham University Hospital
Nottingham, NG7 2UH, United Kingdom
John Radcliffe Hospital
Oxford, OX3 9DU, United Kingdom
Derriford Hospital - Plymouth
Plymouth, PL6 8DH, United Kingdom
Northern General Hospital
Sheffield, S5 7AU, United Kingdom
Southampton General Hospital
Southampton, SO16 6YD, United Kingdom
Joint Clinical Research Facility - Swansea
Swansea, SA2 8PP, United Kingdom
Related Publications (3)
Newsome PN, Sanyal AJ, Engebretsen KA, Kliers I, Ostergaard L, Vanni D, Bugianesi E, Rinella ME, Roden M, Ratziu V. Semaglutide 2.4 mg in Participants With Metabolic Dysfunction-Associated Steatohepatitis: Baseline Characteristics and Design of the Phase 3 ESSENCE Trial. Aliment Pharmacol Ther. 2024 Dec;60(11-12):1525-1533. doi: 10.1111/apt.18331. Epub 2024 Oct 16.
PMID: 39412509RESULTSanyal AJ, Newsome PN, Kliers I, Ostergaard LH, Long MT, Kjaer MS, Cali AMG, Bugianesi E, Rinella ME, Roden M, Ratziu V; ESSENCE Study Group. Phase 3 Trial of Semaglutide in Metabolic Dysfunction-Associated Steatohepatitis. N Engl J Med. 2025 Jun 5;392(21):2089-2099. doi: 10.1056/NEJMoa2413258. Epub 2025 Apr 30.
PMID: 40305708DERIVEDRowe IA, Allen AM. Hepatic steatosis provides the terroir that promotes the development of cardiovascular risk factors and disease. Hepatology. 2023 Jun 1;77(6):1843-1845. doi: 10.1097/HEP.0000000000000327. Epub 2023 Feb 6. No abstract available.
PMID: 36738088DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Clinical Transparency (dept. 2834)
Novo Nordisk A/S
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Masking Details
- Sponsor staff involved in the clinical trial is masked according to company standard procedures The trial has two parts, a part 1 and a part 2, in part 2 sponsor will be unblinded
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
March 26, 2021
First Posted
March 30, 2021
Study Start
April 1, 2021
Primary Completion (Estimated)
April 25, 2029
Study Completion (Estimated)
April 25, 2029
Last Updated
April 17, 2026
Record last verified: 2026-04
Data Sharing
- IPD Sharing
- Will share
According to the Novo Nordisk disclosure commitment on novonordisk-trials.com