Factors Influencing of Pulse Pressure Variation (PPV)

NCT04802668 | Completed

• 1 other identifier: 20210101PPV
• Study Type: observational
• Target: 189
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators studied the predictive value of PPV in the patients with different influencing factors;and the method to improve the predictive value,which can improve the application of PPV in ICU.

Conditions

Haemodynamics; Fluid Responsiveness; Pulse Pressure Variation

Keywords

haemodynamics;; Pulse pressure variation;; fluid responsiveness;; Mechanical ventilation;

Outcome Measures

Primary Outcomes (1)

• cardiac output(CO)

  The measurement of cardiac output(CO);

  1 day

Secondary Outcomes (5)

• measurement of Hemodynamic variables from the monitor;

  1 day

• measurement of Pulse pressure variation（PPV）from monitor;

  Research period

• measurement of airway pressure variables from ventilator

  1 day

• P 0.1

  1 day

• Pocc

  1 day

Other Outcomes (3)

• Pes

  1 day

• transpulmonary pressure

  1 day

• Outcome

  28 day

Study Arms (1)

Circulatory failure patients

Circulatory failure patients requiring fluid responsiveness evaluation

Device: Patients were ventilated with assist-control ventilation（A/C） mode at different tidal volume; Behavioral: spontaneous breathing and no spontaneous breathing

Interventions

Patients were ventilated with assist-control ventilation（A/C） mode at different tidal volume DEVICE

Ventilation mode was set to assist-control volume ventilation with different tidal volume, respiratory frequency 15 times/min, PEEP 5 centimeter water column.

Circulatory failure patients

spontaneous breathing and no spontaneous breathing BEHAVIORAL

Data were recorded when patients had and did not have spontaneous breathing

Circulatory failure patients

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with circulatory failure selected to enter the Department of Critical Care Medicine

You may qualify if:

• Patients requiring invasive mechanical ventilation
• Acute circulatory failure,defined as:systolic blood pressure \<90 mmHg or blood pressure in patients with previous hypertension lower than the baseline value\> 40 mmHg; vasoactive drugs are required to maintain blood pressure (mean arterial pressure\> 65 mmHg); with or without signs of hypoperfusion (oliguria\<0.5ml.kg-1.h-1 for at least 2 hours; arterial blood lactic acid\>2.5mmol.L-1; skin mottling)

You may not qualify if:

• The age of the patient is less than 18 years old or more than 80 years old
• Refuse to sign the informed consent to join the group
• Atrial fibrillation and other arrhythmias that seriously affect the output per beat;
• With pregnancy

Sponsors & Collaborators

• Southeast University, China: lead

Study Sites (1)

Ling Liu

Nanjing, Jiangsu, 210009, China

Location

Related Publications (1)

• Chen H, Liang M, He Y, Teboul JL, Sun Q, Xie J, Yang Y, Qiu H, Liu L. Inspiratory effort impacts the accuracy of pulse pressure variations for fluid responsiveness prediction in mechanically ventilated patients with spontaneous breathing activity: a prospective cohort study. Ann Intensive Care. 2023 Aug 17;13(1):72. doi: 10.1186/s13613-023-01167-0.

  PMID: 37592166 DERIVED

Study Officials

• Haibo Qiu, MD

  professor

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Professor

Study Record Dates

• First Submitted: February 6, 2021
• First Posted: March 17, 2021
• Study Start: March 20, 2021
• Primary Completion: March 30, 2022
• Study Completion: July 30, 2022
• Last Updated: January 10, 2023

Record last verified: 2023-01

Locations

CN (1)