Pulse Pressure Variation in Spontaneously Breathing Patients
The Ability of Pulse Pressure Variation to Predict Fluid Responsiveness in Spontaneously Breathing Patients Undergoing Thoracic Surgery
1 other identifier
interventional
70
1 country
1
Brief Summary
The investigators hypothesized that pulse pressure variation (PPV) could predict fluid responsiveness in spontaneously breathing patients undergoing anesthesia induction.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started May 2011
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2011
CompletedFirst Submitted
Initial submission to the registry
May 29, 2011
CompletedFirst Posted
Study publicly available on registry
July 26, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
October 1, 2011
CompletedApril 21, 2016
July 1, 2011
4 months
May 29, 2011
April 20, 2016
Conditions
Outcome Measures
Primary Outcomes (1)
pulse pressure variation
three respiratory cycles, an expected average of 30 seconds
Secondary Outcomes (1)
hemodynamic parameters
before and after fluid loading, 1 mimute
Study Arms (1)
fluid infusion
EXPERIMENTALInterventions
fluid loading will be performed by hydroxyethyl starch solution (Voluven), at 6 mL/kg
Eligibility Criteria
You may qualify if:
- patients undergoing thoracic surgery
You may not qualify if:
- preoperative arrhythmia
- left ventricular ejection fraction \<40%
- intra-cardiac valve disease
- intra-cardiac shunt
- pulmonary artery hypertension
- severe peripheral vascular obstructive disease
- decreased pulmonary function
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Seoul National University Hospital
Seoul, Seoul, 110-744, South Korea
MeSH Terms
Interventions
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
May 29, 2011
First Posted
July 26, 2011
Study Start
May 1, 2011
Primary Completion
September 1, 2011
Study Completion
October 1, 2011
Last Updated
April 21, 2016
Record last verified: 2011-07