Effect of Aging on Cortical Excitability and Motor Learning
ACE
Effects of Aging on Cortical Excitability During Motor Learning
1 other identifier
interventional
30
1 country
1
Brief Summary
The objective of the current proposal is to identify 1) how aging-related changes in GABAergic cortical inhibition affect motor performance, and 2) how aerobic exercise may improve inhibitory function and facilitate motor learning.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Mar 2019
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 20, 2018
CompletedFirst Posted
Study publicly available on registry
November 23, 2018
CompletedStudy Start
First participant enrolled
March 4, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 30, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
September 30, 2024
CompletedResults Posted
Study results publicly available
April 3, 2025
CompletedApril 3, 2025
April 1, 2025
4.6 years
November 20, 2018
December 3, 2024
April 1, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Magnetic Resonance Spectroscopy
Measuring changes in dynamic magnetic resonance spectroscopy of primary motor cortex during motor learning.
Baseline and12 weeks
Study Arms (2)
Aerobic Exercise
EXPERIMENTALParticipants will engage in an aerobic exercise program meeting thrice weekly for a period of 12 weeks.
Stretching and Balance Training
ACTIVE COMPARATORParticipants will engage in a balance and stretching comparator condition meeting thrice weekly for 12 weeks.
Interventions
Participants will engage in an aerobic exercise program meeting thrice weekly for a period of 12 weeks.
Participants will engage in a balance and stretching comparator condition meeting thrice weekly for 12 weeks.
Eligibility Criteria
You may qualify if:
- living persons aged 50-85
You may not qualify if:
- unmanaged diabetes
- participants completing vigorous exercise per week
- participants whose profession requires vigorous physical labor
- contraindication to magnetic resonance imaging
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Atlanta VA Medical and Rehab Center, Decatur, GA
Decatur, Washington, 30033-4004, United States
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Limitations and Caveats
COVID-19 impacted the in person exercise interventions
Results Point of Contact
- Title
- Dr. Joe Nocera, PI
- Organization
- Department of Veterans Affairs
Study Officials
- PRINCIPAL INVESTIGATOR
Joe R. Nocera, PhD
Atlanta VA Medical and Rehab Center, Decatur, GA
Publication Agreements
- PI is Sponsor Employee
- Yes
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- FED
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 20, 2018
First Posted
November 23, 2018
Study Start
March 4, 2019
Primary Completion
September 30, 2023
Study Completion
September 30, 2024
Last Updated
April 3, 2025
Results First Posted
April 3, 2025
Record last verified: 2025-04
Data Sharing
- IPD Sharing
- Will not share