Depression, Anxiety and Social Relationships as Risk Factors for Dementia

NCT04786561 | Completed

• 1 other identifier: 181011
• Study Type: observational
• Target: 11,000
• Locations: 1 country
• Sites: 1

Brief Summary

The main objective of the present work is to establish a firm knowledge base regarding depression and anxiety as risk factors for dementia and how social relationships impact this association. This risk factors, and efforts to reduce them are described through a follow up over three decades.

Conditions

Dementia; Dementia Alzheimers; Risk Factor; Depression; Anxiety; Social Isolation; Loneliness

Outcome Measures

Primary Outcomes (2)

• Incidence of dementia diagnosis in HUNT4 70+ study

  Two clinical and scientific experts will independently set at diagnosis of cognitive impairment or dementia based on all available information applying standard diagnostic criteria DSM-5.

  2017-2019

• Incidence of Minimal Cognitive Impairment (MCI) in the HUNT 70+ study

  Two clinical and scientific experts will independently set at diagnosis of cognitive impairment or dementia based on all available information applying standard diagnostic criteria DSM-5.

  2017-2019

Secondary Outcomes (1)

• Change in loneliness

  1995-2019

Study Arms (2)

HUNT4 70+

All inhabitants of Nord-Trøndelag 70 years or older were invited to participate in HUNT 4 70+. HUNT4 refers to the fourth wave of the HUNT-study (HelseUndersøkelse i Nord-Trøndelag or health survey in northern part of Trøndelag community in Middle of Norway) and 70+ refers to the part of the survey directed to participants aged seventy years and older.

HUNT4 70+ Trondheim

All inhabitants of one district in Trondheim 70 years or older were invited to participate in HUNT 4 70+

Eligibility Criteria

• Age: 70 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Inhabitants living in the designated areas that voluntared to the health survey and accepted a cognitive test.

You may qualify if:

• Living in designated area

You may not qualify if:

• None

Sponsors & Collaborators

• Norwegian Centre for Ageing and Health: lead
• Norwegian Health Association: collaborator
• Norwegian University of Science and Technology: collaborator
• Norwegian Institute of Public Health: collaborator
• University College, London: collaborator

Study Sites (1)

Norwegian national advisory unit on Ageing and Health

Tønsberg, Norway

Location

Related Publications (1)

• Aunsmo RH, Strand BH, Bergh S, Hansen T, Kivimaki M, Kohler S, Krokstad S, Langballe EM, Livingston G, Matthews FE, Selbaek G. Loneliness trajectories and dementia risk: Insights from the HUNT cohort study. Alzheimers Dement (Amst). 2025 Jul 29;17(3):e70154. doi: 10.1002/dad2.70154. eCollection 2025 Jul-Sep.

  PMID: 40735047 DERIVED

MeSH Terms

Conditions

Dementia; Alzheimer Disease; Depression; Anxiety Disorders; Social Isolation

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurocognitive Disorders; Mental Disorders; Tauopathies; Neurodegenerative Diseases; Behavioral Symptoms; Behavior; Social Behavior

Study Officials

• Geir Selbæk, Phd

  Norwegian National Advisory Unit on Ageing and Health

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 6, 2020
• First Posted: March 8, 2021
• Study Start: January 1, 2020
• Primary Completion: January 1, 2024
• Study Completion: January 1, 2024
• Last Updated: March 22, 2024

Record last verified: 2024-03

Data Sharing

• IPD Sharing: Will not share

Locations

NO (1)