Hearing Impairment as a Risk Factor for Dementia in Older Adults

NCT04284384 | Completed

• 1 other identifier: 181009
• Study Type: observational
• Target: 6,952
• Locations: 1 country
• Sites: 1

Brief Summary

This Doctor of Philosophy (PhD) project is part of a larger project on potentially modifiable risk factors for dementia in a life course perspective, with an overarching aim to improve prevention of dementia and thereby potentially relieve patient and caregiver distress and decrease societal load. The present PhD project will concentrate on confirming knowledge of HI as an independent risk factor for dementia and exploring potentially causative factors to explain this relationship.

Conditions

Dementia; Hearing Loss

Outcome Measures

Primary Outcomes (3)

• Rate of dementia diagnosis in the HUNT 70+ study

  Two clinical and scientific experts will independently set at diagnosis of cognitive impairment or dementia based on all available information applying standard diagnostic criteria Diagnostic and Statistical Manual of Mental Disorders 5 (DSM-5).

  2017-2019

• Rate of Minimal Cognitive Impairment (MCI) in the HUNT 70+ study

  Two clinical and scientific experts will independently set at diagnosis of cognitive impairment or dementia based on all available information applying standard diagnostic criteria DSM-5.

  2017-2019

• Rate of cognitive impairment defined as age- and education-adjusted thresholds on cognitive assessments scales

  The participants have been assessed with the Montreal Cognitive Assessment scale and the ten-word recall test

  2017-2019

Study Arms (2)

HUNT4 70+

All inhabitants of Nord-Trøndelag 70 years of age or older were invited to participate in HUNT4 70+.

HUNT Trondheim 70+

All inhabitants of one district in Trondheim 70 years of age or older were invited to participate in HUNT4 70+.

Eligibility Criteria

• Age: 70 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

HUNT2 and HUNT4 hearing studies: Participants from 17 of the 24 municipalities in the county were offered and accepted a hearing examination, consisting of pure-tone audiometry and two questionnaires on hearing issues, such as use of hearing aids, noise exposure, and tinnitus. HUNT4 70+/HUNT Trondheim 70+: All participants 70 years of age or older are invited to participate in HUNT4 70+ including cognitive screening examinations.

You may qualify if:

• Living in designated area

You may not qualify if:

• None

Sponsors & Collaborators

• Norwegian Centre for Ageing and Health: lead
• Norwegian University of Science and Technology: collaborator
• The Nord-Trøndelag Health Study: collaborator
• The Norwegian Institute of Public Health: collaborator
• University College London Hospitals: collaborator
• University of Oslo: collaborator

Study Sites (1)

Norwegian National Advisory Unit of Ageing and Health

Tønsberg, Norway

Location

Related Publications (3)

• GjOra L, Strand BH, Bergh S, Borza T, Braekhus A, Engedal K, Johannessen A, Kvello-Alme M, Krokstad S, Livingston G, Matthews FE, Myrstad C, Skjellegrind H, Thingstad P, Aakhus E, Aam S, Selbaek G. Current and Future Prevalence Estimates of Mild Cognitive Impairment, Dementia, and Its Subtypes in a Population-Based Sample of People 70 Years and Older in Norway: The HUNT Study. J Alzheimers Dis. 2021;79(3):1213-1226. doi: 10.3233/JAD-201275.

  PMID: 33427745 BACKGROUND

• Myrstad C, Engdahl BL, Costafreda SG, Krokstad S, Livingston G, Selbaek G. Hearing and cognitive scores measured with the Montreal Cognitive Assessment Scale in The HUNT Study, Norway. Alzheimers Dement. 2025 Feb;21(2):e14514. doi: 10.1002/alz.14514. Epub 2025 Jan 23.

  PMID: 39846386 DERIVED

• Myrstad C, Engdahl BL, Costafreda SG, Krokstad S, Lin F, Livingston G, Strand BH, Ohre B, Selbaek G. Hearing impairment and risk of dementia in The HUNT Study (HUNT4 70+): a Norwegian cohort study. EClinicalMedicine. 2023 Dec 4;66:102319. doi: 10.1016/j.eclinm.2023.102319. eCollection 2023 Dec.

  PMID: 38192588 DERIVED

MeSH Terms

Conditions

Dementia; Hearing Loss

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurocognitive Disorders; Mental Disorders; Hearing Disorders; Ear Diseases; Otorhinolaryngologic Diseases; Sensation Disorders; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Geir Selbæk, PhD

  Norwegian Centre for Ageing and Health

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 6, 2020
• First Posted: February 25, 2020
• Study Start: August 19, 2019
• Primary Completion: November 20, 2020
• Study Completion: November 20, 2020
• Last Updated: September 14, 2021

Record last verified: 2021-09

Data Sharing

• IPD Sharing: Will not share

Locations

NO (1)