Blood Loss and Preeclampsia
Does Preeclampsia Affect Blood Loss During a Caesarean Procedure
1 other identifier
observational
120
1 country
1
Brief Summary
Study of blood loss in preeclamptic patients using mathematical formulae
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Jan 2021
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2021
CompletedFirst Submitted
Initial submission to the registry
February 25, 2021
CompletedFirst Posted
Study publicly available on registry
March 2, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 28, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
February 28, 2025
CompletedDecember 5, 2023
December 1, 2023
4.2 years
February 25, 2021
December 4, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Blood-Loss
Corelation between blood loss and coagulation parameters will be calculated
day 1
Secondary Outcomes (1)
Coagulation parameter
day 1
Study Arms (2)
healthy pregnant women
Healthy patients who receive a cesarean operation
Pre-eclampsia
Patients with pre-eclampsia who receive a caesarean operation
Interventions
Two blood sample will be drawn. On the day of operation and the first postoperative day.
Eligibility Criteria
Patients with pre-eclampsia planed for cesarean section vs. healty pregnant women, planmned for cesarean section
You may qualify if:
- Elective or urgent caesarean section
- Written informed consent
You may not qualify if:
- Emergency caesarean section
- Familial coagulation disorder
- Hematological disorders that affect the platelet count, e.g. myelodysplastic syndrome (MDS)
- Taking anticoagulants
- Taking aspirin in the last 14 days
- Use of NSARs in the last 24 hours
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University Hospital Zurich, Institute for Anesthesiology
Zurich, 8091, Switzerland
Related Publications (3)
Brecher ME, Monk T, Goodnough LT. A standardized method for calculating blood loss. Transfusion. 1997 Oct;37(10):1070-4. doi: 10.1046/j.1537-2995.1997.371098016448.x.
PMID: 9354828RESULTTheusinger OM, Kind SL, Seifert B, Borgeat L, Gerber C, Spahn DR. Patient blood management in orthopaedic surgery: a four-year follow-up of transfusion requirements and blood loss from 2008 to 2011 at the Balgrist University Hospital in Zurich, Switzerland. Blood Transfus. 2014 Apr;12(2):195-203. doi: 10.2450/2014.0306-13.
PMID: 24931841RESULTde Lange NM, Lance MD, de Groot R, Beckers EA, Henskens YM, Scheepers HC. Obstetric hemorrhage and coagulation: an update. Thromboelastography, thromboelastometry, and conventional coagulation tests in the diagnosis and prediction of postpartum hemorrhage. Obstet Gynecol Surv. 2012 Jul;67(7):426-35. doi: 10.1097/OGX.0b013e3182605861.
PMID: 22926249RESULT
Biospecimen
Blood Samples
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Marco P Zalunardo
Institut of Anesthesiology University Hospital Zurich
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
February 25, 2021
First Posted
March 2, 2021
Study Start
January 1, 2021
Primary Completion
February 28, 2025
Study Completion
February 28, 2025
Last Updated
December 5, 2023
Record last verified: 2023-12