Contribution of the Pharmacological Profile of the A2A Receptor to Adenosine in the Diagnosis of Myocardial Ischemia

NCT04640844 | Unknown

• 2 other identifiers: 2020-132020-A00686-33
• Study Type: interventional
• Target: 170
• Locations: 1 country
• Sites: 1

Brief Summary

The chronic coronary artery disease could be detected by a drop in the expression of A2A receptors to adenosine, while high values of the KD / EC50 ratio are a sign of coronary ischemia. Knowing the number of A2A receptors in circulating lymphocytes could allow detection of coronary artery disease and evaluating the functionality of A2A receptors in circulating lymphocytes could allow quantification of myocardial ischemia. Thus, a simple and unique blood sample would quickly detect patients with life-threatening coronary ischemia. This would avoid prolonged hospitalizations and costly non-invasive tests (stress echocardiography, myocardial scintigraphy) in patients without coronary artery disease.

Conditions

Chronic Coronary Artery Disease

Outcome Measures

Primary Outcomes (1)

• Dosage of adenosine

  measuring the expression and function of lymphocyte A2A receptors.

  24 MONTHS

Study Arms (1)

patients hospitalized

EXPERIMENTAL

for surgery of the aorta and / or arteries of the lower limbs.

Biological: blood sample

Interventions

blood sample BIOLOGICAL

measuring the expression and function of lymphocyte A2A receptors.

patients hospitalized

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients admitted for preoperative assessment of vascular surgery of the aorta and / or arteries of the lower limbs.
• Adult person (age\> 18).
• Affiliated with a social security scheme.
• Signature of informed consent.

You may not qualify if:

• Patients with a history of coronary artery disease awaiting revascularization.
• Hyperthyroidism, anemia (Hb \<13 g / dL).
• Contraindication to the practice of coronary angiography, stress echocardiography or myocardial scintigraphy.
• Unstable hemodynamic state or cardiogenic shock.
• Adults protected under guardianship, curatorship or legal protection.
• Pregnant or lactating women

Sponsors & Collaborators

• Assistance Publique Hopitaux De Marseille: lead

Study Sites (1)

Assistance Publique Hopitaux de Marseille

Marseille, France

RECRUITING

MeSH Terms

Interventions

Blood Specimen Collection

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Study Officials

• Emilie GARRIDO PRADALIE

  Assistance Publique Hopitaux De Marseille

  STUDY DIRECTOR

Central Study Contacts

ALAEXANDRA GIULIANI

CONTACT

0491382747; alexandra.giuliani@ap-hm.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 12, 2020
• First Posted: November 23, 2020
• Study Start: January 25, 2021
• Primary Completion: December 1, 2022
• Study Completion: June 1, 2023
• Last Updated: May 28, 2021

Record last verified: 2021-05

Locations

FR (1)