NCT02198937

Brief Summary

Investigation on the effect of smoking on thrombus formation in humans. The expression of pro- and anti-thrombotic, anti-oxidative, and inflammatory markers will be assessed in 25-50 year old healthy smokers and non-smokers. The investigators are interested in possible differences between the two groups.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
10

participants targeted

Target at below P25 for all trials

Timeline
Completed

Started Jun 2014

Geographic Reach
1 country

1 active site

Status
terminated

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 2014

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

July 21, 2014

Completed
3 days until next milestone

First Posted

Study publicly available on registry

July 24, 2014

Completed
1.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2016

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2016

Completed
Last Updated

October 25, 2016

Status Verified

October 1, 2016

Enrollment Period

1.8 years

First QC Date

July 21, 2014

Last Update Submit

October 24, 2016

Conditions

InflammationThrombosisSmoking

Keywords

smokersnon-smokers

Outcome Measures

Primary Outcomes (1)

  • Expression of pro- and anti-thrombotic, anti-oxidative, and inflammatory markers in blood

    Single time point, no follow-up (cross sectional)

Study Arms (2)

Smokers

Healthy smokers

Other: Blood sample

Non-Smokers

Healthy non-smokers

Other: Blood sample

Interventions

Blood sampleOTHER
Non-SmokersSmokers

Eligibility Criteria

Age25 Years - 50 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)
Sampling MethodProbability Sample
Study Population

Smokers and non-smokers

You may qualify if:

  • Smoker
  • Non-smokers

You may not qualify if:

  • Disease
  • Pregnancy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University Hospital

Zurich, Switzerland

Location

Biospecimen

Blood sample

MeSH Terms

Conditions

InflammationThrombosisSmoking

Interventions

Blood Specimen Collection

Condition Hierarchy (Ancestors)

Pathologic ProcessesPathological Conditions, Signs and SymptomsEmbolism and ThrombosisVascular DiseasesCardiovascular DiseasesBehavior

Intervention Hierarchy (Ancestors)

Specimen HandlingClinical Laboratory TechniquesDiagnostic Techniques and ProceduresDiagnosisPuncturesSurgical Procedures, OperativeInvestigative Techniques

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
MD

Study Record Dates

First Submitted

July 21, 2014

First Posted

July 24, 2014

Study Start

June 1, 2014

Primary Completion

March 1, 2016

Study Completion

March 1, 2016

Last Updated

October 25, 2016

Record last verified: 2016-10

Locations

CH(1)