Impact of Age and Geriatric Co-morbidities on Lymphocyte Phenotype in Patients 70 Years of Age and Older

NCT04772092 | Withdrawn

• 1 other identifier: BARBEN 2020
• Study Type: observational
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

An individual's immune profile changes with age, and can sometimes be involved in the development of certain diseases such as infections or cancers, in a process called immunosenescence. Some data tend to show that there is a link between this immune profile and geriatric fragility (autonomy, difficulties with walking, memory, undernutrition, co-morbidities, depression). The aim of this study is to describe this profile, or immune phenotype, and to see if there is a link with the different aspects of geriatric assessment in patients without cancer or infection. In addition, these data will serve as a basis for comparison with the same analyses performed on breast cancer patients at the Centre Georges François Leclerc.

Conditions

Geriatrics Immunosenescence

Outcome Measures

Primary Outcomes (1)

• percentage of immune cells in peripheral blood

  technique used: flow cytometry

  At inclusion

Study Arms (1)

Seniors

70 years of age and over, inpatients or outpatients

Biological: Blood samples; Other: Data collection

Interventions

Blood samples BIOLOGICAL

during the routine blood test, collection of additional blood samples: * 1 x 5 mL heparinized tube for plasma collection and storage * 1 heparinized 5 mL tube for immunophenotyping * 4 x 10 mL EDTA tubes for white blood cell (WBC) collection and cryopreservation

Seniors

Data collection OTHER

* clinical examination data * test results to measure the degree of geriatric fatigability * Frailty screening questionnaire for neoplasia patients (G8 score)

Seniors

Eligibility Criteria

• Age: 70 Years+
• Sex: all
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

A person at least 70 years of age admitted to the Champmaillot Geriatric Center on an inpatient or outpatient basis.

You may qualify if:

• Male or female aged 70 and over admitted to the Champmaillot Geriatric Center on an inpatient or outpatient basis.

You may not qualify if:

• Person not affiliated to national health insurance system
• Person subject to a measure of legal safeguard (curatorship, etc)
• Person with an acute infection
• Person with suspected cancer or active cancer
• Long-term immunosuppressive or corticosteroid therapy
• HIV and/or HBV and/or HCV positive serology

Sponsors & Collaborators

• Centre Hospitalier Universitaire Dijon: lead

MeSH Terms

Interventions

Blood Specimen Collection; Data Collection

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques; Epidemiologic Methods; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 24, 2021
• First Posted: February 26, 2021
• Study Start: November 1, 2021
• Primary Completion: November 1, 2021
• Study Completion: November 1, 2021
• Last Updated: September 8, 2022

Record last verified: 2022-09