LIdocaine veRsus Sufentanil Anaesthesia in Cardiac Surgery With Cardiopulmonary Bypass

NCT05136794 | Completed

• 1 other identifier: GUINOT 2021-4
• Study Type: observational
• Target: 1,772
• Locations: 1 country
• Sites: 1

Brief Summary

Since the 90's the concept of morphine sparing and morphine free anaesthesia (OFA) has progressively developed in non-cardiac surgery. The principle is based on the fact that in a sleeping patient a sympathetic reaction marked by hemodynamic modifications does not translate into a painful phenomenon, that a painful phenomenon in a sleeping patient is not memorized, that hormonal stress, the sympathetic reaction and the inflammatory reaction can be controlled by other therapeutic classes than a morphine agent. This therapeutic management would avoid the side effects associated with the use of morphine. In this hypothesis, OFA is more and more practiced in various situations without the real impact in terms of clinical benefit being clearly demonstrated. In cardiac surgery, some centers practice OFA with various protocols.The purpose of this work is to retrospectively evaluate over a defined period the incidence of postoperative complications, length of stay in the ICU/hospital, and death rate between patients managed with/without OFA based on lidocaine.

Conditions

Opioid Free Anaesthesia; Opioid Anaesthesia

Outcome Measures

Primary Outcomes (1)

• ICU stays (days)

  Total stay in ICU in day

  Day 30

Secondary Outcomes (2)

• Complications

  Day 30

• Hospital stays (days)

  Day 30

Study Arms (2)

Opioid free anaesthesia

patient anesthtesized with lidocaine

Other: Data collection

Opioid anaesthesia

patients anesthetized with sufentanil

Other: Data collection

Interventions

Data collection OTHER

complications: cardiac, neurological, renal, respiratory, red blood transfusion Hospital stays: ICU stays and hospital stay

Opioid anaesthesia; Opioid free anaesthesia

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Cardiac surgical

You may qualify if:

• age over 18 years Cardiac surgery with cardiopulmonary bypass performed between January 2019 and June 2021

You may not qualify if:

• LVAD Heart transplantation Incomplete data in relation to outcomes

Sponsors & Collaborators

• Centre Hospitalier Universitaire Dijon: lead

Study Sites (1)

Chu Dijon Bourgogne

Dijon, France

Location

Related Publications (1)

• Guinot PG, Andrei S, Durand B, Martin A, Duclos V, Spitz A, Berthoud V, Constandache T, Grosjean S, Radhouani M, Anciaux JB, Nguyen M, Bouhemad B. Balanced Nonopioid General Anesthesia With Lidocaine Is Associated With Lower Postoperative Complications Compared With Balanced Opioid General Anesthesia With Sufentanil for Cardiac Surgery With Cardiopulmonary Bypass: A Propensity Matched Cohort Study. Anesth Analg. 2023 May 1;136(5):965-974. doi: 10.1213/ANE.0000000000006383. Epub 2023 Feb 10.

  PMID: 36763521 RESULT

MeSH Terms

Interventions

Data Collection

Intervention Hierarchy (Ancestors)

Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 16, 2021
• First Posted: November 29, 2021
• Study Start: December 1, 2021
• Primary Completion: January 15, 2022
• Study Completion: January 15, 2022
• Last Updated: February 10, 2026

Record last verified: 2026-02

Locations

FR (1)