The Bern Perioperative Biobank

NCT04767685 | Completed DMC

• 1 other identifier: 041/09f
• Study Type: observational
• Target: 547
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of the research is to define clinically relevant molecular markers for increased risk of peri-/ postoperative organo-dysfunctions, inflammation, adverse events and disease progression. To better understand the perioperative impact the investigators aim to determine perioperative levels of molecular markers over time in the available samples and clinical data of the Bern perioperative Biobank (BPBB) cohort to finally increase quality of perioperative care of patients by permitting preventive measures to be taken early in patients at risk.

Conditions

Anesthesia; Surgical Procedure, Operative

Keywords

Genetic association study

Outcome Measures

Primary Outcomes (3)

• Assessing the change of the metabolic profile in the perioperative setting

  Surgery causes significant disruption of physiologic metabolism. The investigators currently lack specific markers to assess change of the metabolic profile in the perioperative setting. The investigators aim to identify metabolic markers and their change in the perioperative period in association with patients' clinical outcome.

  Before induction of anesthesia as baseline

• Assessing the change of the metabolic profile in the perioperative setting

  Surgery causes significant disruption of physiologic metabolism. The investigators currently lack specific markers to assess change of the metabolic profile in the perioperative setting. The investigators aim to identify metabolic markers and their change in the perioperative period in association with patients' clinical outcome.

  Ca. 2-5hours later upon finishing the surgery

• Assessing the change of the metabolic profile in the perioperative setting

  Surgery causes significant disruption of physiologic metabolism. The investigators currently lack specific markers to assess change of the metabolic profile in the perioperative setting. The investigators aim to identify metabolic markers and their change in the perioperative period in association with patients' clinical outcome.

  On postoperative day 1 during the morning round between 07:30-9:00am

Study Arms (1)

All patients

Consenting patients undergoing non-emergency surgery with anesthesia

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients scheduled for non-emergency surgery

You may qualify if:

• years and older
• Written informed consent
• Non-emergency surgery

You may not qualify if:

• Transient incapacity to consent or insufficient time (\< 6h) to consider study participation
• No informed consent
• Cognitive impairment/Patients unable to consent
• Patients who retrospectively expressed their wish to be excluded

Sponsors & Collaborators

• Insel Gruppe AG, University Hospital Bern: lead

Study Sites (1)

Department of Anaesthesiology and Pain Medicine, Inselspital, University of Bern

Bern, 3010, Switzerland

Location

Related Publications (2)

• Bello C, Filipovic MG, Huber M, Flannery S, Kobel B, Fischer R, Kessler BM, Raber L, Stueber F, Luedi MM. Discovery of plasma proteome markers associated with clinical outcome and immunological stress after cardiac surgery. Front Cardiovasc Med. 2023 Dec 22;10:1287724. doi: 10.3389/fcvm.2023.1287724. eCollection 2023.

  PMID: 38379859 DERIVED

• Heinisch PP, Mihalj M, Huber M, Schefold JC, Hartmann A, Walter M, Steinhagen-Thiessen E, Schmidli J, Stuber F, Raber L, Luedi MM. Impact of Lipoprotein(a) Levels on Perioperative Outcomes in Cardiac Surgery. Cells. 2021 Oct 21;10(11):2829. doi: 10.3390/cells10112829.

  PMID: 34831051 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

Whole blood (plasma and cells)

Study Officials

• Frank Stüber, Prof. MD

  Department of Anaesthesiology and Pain Medicine, Inselspital, University of Bern

  STUDY CHAIR

• Markus M Lüdi, MD

  Department of Anaesthesiology and Pain Medicine, Inselspital, University of Bern

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 16, 2020
• First Posted: February 23, 2021
• Study Start: January 1, 2011
• Primary Completion: December 1, 2021
• Study Completion: December 1, 2021
• Last Updated: November 15, 2022

Record last verified: 2022-11

Locations

CH (1)