NCT04327258

Brief Summary

Crosssectional study to analyse the genetic influence on levels of cardiac biomarkers (BNP, NT-proBNP).

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
437

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jan 2011

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2011

Completed
3.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2014

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2014

Completed
5.3 years until next milestone

First Submitted

Initial submission to the registry

March 26, 2020

Completed
5 days until next milestone

First Posted

Study publicly available on registry

March 31, 2020

Completed
Last Updated

March 31, 2020

Status Verified

March 1, 2020

Enrollment Period

3.9 years

First QC Date

March 26, 2020

Last Update Submit

March 26, 2020

Conditions

AnesthesiaSurgical Procedure, Operative

Keywords

genetic association study

Outcome Measures

Primary Outcomes (1)

  • Influence of NPPA/NPPB haplotype on natriuretic peptide plasma levels

    Estimation of genetic effects on natriuretic peptide (BNP, NT-proBNP) plasma levels

    Blood samples collected at start of anesthetic procedure

Study Arms (1)

All patients

Patients undergoing elective surgery with anesthesia

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients scheduled for elective surgery

You may qualify if:

  • years and older
  • Written informed consent
  • Scheduled surgery

You may not qualify if:

  • No informed consent
  • Cognitive impairment

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Department of Anaesthesiology and Pain Medicine, Inselspital, University of Bern

Bern, 3010, Switzerland

Location

Biospecimen

Retention: SAMPLES WITH DNA

Whole blood (plasma and cells)

Study Officials

  • Frank Stüber, Prof. MD

    Department of Anaesthesiology and Pain Medicine, Inselspital, University of Bern

    STUDY CHAIR

  • Ulrike M Stamer, MD

    Department of Anaesthesiology and Pain Medicine, Inselspital, University of Bern

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 26, 2020

First Posted

March 31, 2020

Study Start

January 1, 2011

Primary Completion

December 1, 2014

Study Completion

December 1, 2014

Last Updated

March 31, 2020

Record last verified: 2020-03

Locations

CH(1)