NCT01021228

Brief Summary

The purpose of this study is to compare the impact and outcome of continuous volatile anesthesia to continuous intravenous anesthesia and to preconditioning volatile anesthesia in liver surgery.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
257

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Aug 2008

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 1, 2008

Completed
1.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2009

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2009

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

November 25, 2009

Completed
1 day until next milestone

First Posted

Study publicly available on registry

November 26, 2009

Completed
Last Updated

November 26, 2009

Status Verified

November 1, 2009

Enrollment Period

1.2 years

First QC Date

November 25, 2009

Last Update Submit

November 25, 2009

Conditions

Anesthesia

Keywords

Liver resectionContinuous volatile anesthesiaContinuous intravenous anesthesiaPreconditioning volatile anesthesiaComparing three groups of anesthesia during the liver surgery according to their benefit on liver and outcome.

Outcome Measures

Primary Outcomes (1)

  • peak ALT and AST levels representing the ischemia-reperfusion injury

    post-operative

Secondary Outcomes (1)

  • length of hospital stay, length of ICU stay, blood loss and morbidity (post-operative complications)

    post-operative

Study Arms (3)

group1

continuous volatile anesthesia (sevoflurane) during the liver resection

group2

continuous intravenous anesthesia (propofol) during the liver resection

group3

preconditioning volatile anesthesia (sevoflurane) 30 minutes before ischemia (inflow occlusion)

Eligibility Criteria

Age18 Years - 90 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Consecutive patients were included undergoing any type of liver resection with inflow occlusion for benign as well as malign diseases between January first, 2005 and December 31, 2007 in a single tertiary care center

You may qualify if:

  • \> 18 years
  • benign and malign disease
  • any type of liver surgery
  • inflow occlusion during the liver surgery

You may not qualify if:

  • \< 18 years
  • participation on other interventional and treatment randomized controlled trials,
  • trauma of the liver
  • liver cirrhosis

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Universtiy Hospital of Zurich, Department of Visceral and Transplantation Surgery

Zurich, Canton of Zurich, 8091, Switzerland

Location

Study Officials

  • Ksenija Slankamenac, med. pract

    Departement of Visceral and Transplantation

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER

Study Record Dates

First Submitted

November 25, 2009

First Posted

November 26, 2009

Study Start

August 1, 2008

Primary Completion

October 1, 2009

Study Completion

October 1, 2009

Last Updated

November 26, 2009

Record last verified: 2009-11

Locations

CH(1)