Surgical Resection Outcomes in Patients With Brain Metastasis

NCT06318065 | Recruiting

• 1 other identifier: B-ER111-370
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

While many studies have investigated the prognostic factors for patients undergoing surgical resection for primary brain tumors, decision-making for patients with brain metastasis (BM) is more complex because of their higher burden of comorbidities compared to those with primary brain tumors. In addition, although various prognostic indicators have been identified to predict prognosis in several types of cancer, such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), prognostic nutritional index (PNI), and systemic immune-inflammation index (SII), limited studies have yet determined which group of patients would yield beater survival outcome after surgical resection for BM. This study aimed to investigate the impact of patient and perioperative characteristics and prognostic indicators on survival outcome of patients undergoing surgical resection of BM.

Conditions

Brain Metastases

Outcome Measures

Primary Outcomes (2)

• survival outcome of patients undergoing surgery for brain metastasis

  overall survival of patients

  From date of surgery until the date of death from any cause, whichever came first, assessed up to 100 months

• Functional outcome of patients undergoing surgery for brain metastasis

  change of preoperative and postoperative modified rankin scale

  from date of surgery until 6 months after surgery ordate of death from any cause, whichever came first

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients newly diagnosed with BM due to various primary cancers who underwent surgery at our institution

You may qualify if:

• patients with Clinical diagnosis of brain metastasis
• patients who underwent craniotomy surgery for brain metastasis

You may not qualify if:

• patients with insufficient data for associated factors
• patients who underwent stereotactic biopsy for brain metastasis
• patients who did not undergo craniotomy surgery for brain metastasis

Sponsors & Collaborators

• National Cheng-Kung University Hospital: lead

Study Sites (1)

Jung-Shun Lee

Tainan, None Selected, 70403, Taiwan

RECRUITING

MeSH Terms

Conditions

Brain Neoplasms

Condition Hierarchy (Ancestors)

Central Nervous System Neoplasms; Nervous System Neoplasms; Neoplasms by Site; Neoplasms; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Study Officials

• Jung-Shun Lee, M.D.

  National Cheng Kung Univsersity Hospital

  STUDY CHAIR

Central Study Contacts

Jung-Shun Lee, M.D.

CONTACT

886-6-2353535; nslee1218@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 25, 2024
• First Posted: March 19, 2024
• Study Start: January 1, 2010
• Primary Completion: June 1, 2024
• Study Completion: September 1, 2024
• Last Updated: March 22, 2024

Record last verified: 2024-02

Locations

TW (1)