NCT04738929

Brief Summary

The aim of this study is to compare acute effects of consuming extra virgin coconut oil (EVCO) as a source of medium chain fatty acids and extra virgin olive oil (EVOO) as a source of long chain fatty acids in normal weight and obese subjects.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
20

participants targeted

Target at below P25 for not_applicable obesity

Timeline
Completed

Started Jan 2019

Shorter than P25 for not_applicable obesity

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 3, 2019

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 3, 2019

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 3, 2019

Completed
1.6 years until next milestone

First Submitted

Initial submission to the registry

January 20, 2021

Completed
15 days until next milestone

First Posted

Study publicly available on registry

February 4, 2021

Completed
Last Updated

February 4, 2021

Status Verified

February 1, 2021

Enrollment Period

5 months

First QC Date

January 20, 2021

Last Update Submit

February 3, 2021

Conditions

ObesityAppetitive Behavior

Keywords

Extra virgin coconut oil; medium chain fatty acids; extra virgin olive oil; obesity; peptide YY; resting metabolic rate.

Outcome Measures

Primary Outcomes (7)

  • Energy expenditure change

    kcal

    0, 60, 120, 180 minutes

  • Subjective appetite feelings change

    visual analogue scales rating (0-10 cm)

    0, 30, 60, 120, 180 minutes

  • glucose change

    mg/dl

    0, 30, 60, 120, 180 minutes

  • insulin change

    mU/L

    0, 30, 60, 120, 180 minutes

  • peptide YY change

    pg/dl

    0, 30, 60, 120, 180 minutes

  • triglycerides change

    mg/dl

    0, 30, 60, 120, 180 minutes

  • Ad libitum energy intake

    kcal

    180 minute

Study Arms (2)

Normal weight

EXPERIMENTAL

Normal weight subjects (BMI=18.5-25)

Other: Extra virgin coconut oil or extra virgin olive oil

Obese

EXPERIMENTAL

Obese subjects (BMI=30-34.99)

Other: Extra virgin coconut oil or extra virgin olive oil

Interventions

Extra virgin coconut oil or extra virgin olive oilOTHER

Subjects consumed standard breakfast meals containing "extra virgin coconut oil" or "extra virgin olive oil"

Normal weightObese

Eligibility Criteria

Age19 Years - 40 Years
Sexmale(Gender-based eligibility)
Gender Eligibility DetailsOnly male subjects were included to eliminate potential variations due to hormonal changes during menstrual cycles of female subjects.
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Metabolically healthy
  • Aged 19-40 years
  • Normal weight (BMI=18.5-24.9 kg/m²) and obese men (BMI=30-34.99 kg/m²)

You may not qualify if:

  • smoking,
  • alcohol consumption,
  • weight gain/loss recently (\> %5, in three months),
  • any genetic and metabolic diseases,
  • any food allergy/intolerance,
  • any medication,
  • restrained eating habits.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Presidency of Republic of Turkey Health Center

Ankara, Turkey (Türkiye)

Location

Related Publications (1)

  • Metin ZE, Bilgic P, Tengilimoglu Metin MM, Akkoca M. Comparing acute effects of extra virgin coconut oil and extra virgin olive oil consumption on appetite and food intake in normal-weight and obese male subjects. PLoS One. 2022 Sep 16;17(9):e0274663. doi: 10.1371/journal.pone.0274663. eCollection 2022.

    PMID: 36112590DERIVED

MeSH Terms

Conditions

ObesityAppetitive Behavior

Condition Hierarchy (Ancestors)

OverweightOvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and SymptomsBehavior, AnimalBehavior

Study Officials

  • Ziya Erokay Metin, Dr.

    Ankara City Hospital Bilkent

    PRINCIPAL INVESTIGATOR

  • Pelin Bilgiç, Assoc. Prof.

    Hacettepe University

    STUDY CHAIR

  • Mercan Merve Tengilimoğlu Metin, Assis. Prof.

    Hacettepe University

    STUDY CHAIR

  • Muzaffer Akkoca, Assoc. Prof.

    Saglik Bilimleri Universitesi

    STUDY CHAIR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

January 20, 2021

First Posted

February 4, 2021

Study Start

January 3, 2019

Primary Completion

June 3, 2019

Study Completion

June 3, 2019

Last Updated

February 4, 2021

Record last verified: 2021-02

Data Sharing

IPD Sharing
Will not share

Locations

TU(1)